Analysis of the human tumour necrosis factor-alpha (TNFα) gene promoter polymorphisms in children with bone cancer

[...]an increase in the TNF308.1/TNF308.2 genotype has been reported in different tumour types, with a significantly increased frequency of the TNF308.2 allele in patients with malignant tumours. 8 Wilson et al 7 have shown that the polymorphism at -308 has a significant effect on the transcriptiona...

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