Fas gene promoter polymorphisms in primary Sjögren’s syndrome

Background: Fas mediated apoptosis may be important in the pathogenesis of primary Sjögren’s syndrome (pSS). Objective: To examine genetic variation in the promoter region of the Fas gene in pSS. Methods: Two single nucleotide polymorphisms at positions −1377(G/A) and −670(G/A) in the Fas gene promo...

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Veröffentlicht in:	Annals of the rheumatic diseases 2004-01, Vol.63 (1), p.98-101
Hauptverfasser:	Mullighan, C G, Heatley, S, Lester, S, Rischmueller, M, Gordon, T P, Bardy, P G
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Antinuclear - blood Apoptosis CIE Concise Report counterimmunoelectrophoresis Disease ELISA enzyme linked immunosorbent assay Exocrine glands Fas fas Receptor - genetics Gangrene Gene Frequency Genes Genotype Haplotypes Humans Lupus Pathogenesis Polymorphism Polymorphism, Genetic primary Sjögren’s syndrome Promoter Regions, Genetic - genetics pSS Rodents Sjogren's Syndrome - genetics Sjogren's Syndrome - immunology Sjögren’s syndrome Studies Thermal cycling Tumor necrosis factor-TNF
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