Angiopoietin-1 is expressed in the synovium of patients with rheumatoid arthritis and is induced by tumour necrosis factor α

Objectives: To examine the potential role of the angiogenic growth factor angiopoietin-1 (Ang-1) in inflammatory arthritis. Methods: Eighteen synovial tissue samples were obtained from 17 patients with a clinical diagnosis of rheumatoid arthritis (RA) and compared with six synovial tissue samples fr...

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Veröffentlicht in:	Annals of the rheumatic diseases 2003-02, Vol.62 (2), p.100-107
Hauptverfasser:	Gravallese, E M, Pettit, A R, Lee, R, Madore, R, Manning, C, Tsay, A, Gaspar, J, Goldring, M B, Goldring, S R, Oettgen, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Ang-1 angiogenesis Angiogenesis Inducing Agents - genetics Angiogenesis Inducing Agents - metabolism Angiogenin Angiopoietin-1 Angiopoietin-2 Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology basic fibroblast growth factor bFGF Biological and medical sciences Blotting, Northern - methods Care and treatment Case studies CIA collagen induced arthritis Culture Techniques cytokines DAB diaminobenzidine Diseases of the osteoarticular system DMEM Dulbecco’s modified Eagle’s medium ELISA enzyme linked immunosorbent assay Extended Report FCS fetal calf serum Fibroblasts - drug effects Fibroblasts - metabolism Gene expression Genetic aspects Health aspects horseradish peroxidase HRP human umbilical vein endothelial cells Humans HUVECs Immunoenzyme Techniques Immunohistochemistry In Situ Hybridization inflammation Inflammatory joint diseases interleukin Interleukin-1 - pharmacology Medical examination Medical research Medical sciences Medicine, Experimental Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Messenger RNA osteoarthritis Osteoarthritis - metabolism Patients PBS phosphate buffered saline Physiological aspects Prevention Proteins reverse transcriptase-polymerase chain reaction Rheumatoid arthritis RNA, Messenger - genetics RT-PCR Synovial Membrane - blood supply Synovial Membrane - metabolism TBS TNF Tris buffered saline Tumor Necrosis Factor-alpha - pharmacology tumour necrosis factor vascular endothelial growth factor VEGF
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