Differentiation between primary and secondary Raynaud's phenomenon: a prospective study comparing nailfold capillaroscopy using an ophthalmoscope or stereomicroscope
BACKGROUND Nailfold capillary microscopy is a routine procedure in the investigation of patients with Raynaud's phenomenon (RP). As a standard method, nailfold capillary morphology is inspected with a stereomicroscope to look for capillary abnormalities such as giant loops, avascular areas, and...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2001-04, Vol.60 (4), p.407-409 |
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| creator | Anders, H J Sigl, T Schattenkirchner, M |
| description | BACKGROUND Nailfold capillary microscopy is a routine procedure in the investigation of patients with Raynaud's phenomenon (RP). As a standard method, nailfold capillary morphology is inspected with a stereomicroscope to look for capillary abnormalities such as giant loops, avascular areas, and bushy capillaries, which have all been found to be associated with certain connective tissue diseases. AIM To investigate prospectively whether nailfold capillary inspection using an ophthalmoscope is of equivalent diagnostic value to standard nailfold capillary microscopy. METHOD All the fingers of 26 patients with RP were examined in a blinded fashion and compared with the final diagnosis one month later. RESULTS All giant loops, large avascular areas, and bushy capillaries were identified by both methods. The correlation for moderate avascular areas and crossed capillaries was 0.93 and 0.955 respectively. The correlation for minor abnormalities that do not contribute to the differentiation between primary and secondary RP was 0.837 and 0.861 respectively. All patients were classified identically by the two methods. CONCLUSION For the evaluation of patients with RP, nailfold capillary morphology can reliably be assessed with an ophthalmoscope. |
| doi_str_mv | 10.1136/ard.60.4.407 |
| format | Article |
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As a standard method, nailfold capillary morphology is inspected with a stereomicroscope to look for capillary abnormalities such as giant loops, avascular areas, and bushy capillaries, which have all been found to be associated with certain connective tissue diseases. AIM To investigate prospectively whether nailfold capillary inspection using an ophthalmoscope is of equivalent diagnostic value to standard nailfold capillary microscopy. METHOD All the fingers of 26 patients with RP were examined in a blinded fashion and compared with the final diagnosis one month later. RESULTS All giant loops, large avascular areas, and bushy capillaries were identified by both methods. The correlation for moderate avascular areas and crossed capillaries was 0.93 and 0.955 respectively. The correlation for minor abnormalities that do not contribute to the differentiation between primary and secondary RP was 0.837 and 0.861 respectively. All patients were classified identically by the two methods. CONCLUSION For the evaluation of patients with RP, nailfold capillary morphology can reliably be assessed with an ophthalmoscope.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/ard.60.4.407</identifier><identifier>PMID: 11247874</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Biological and medical sciences ; Blood vessels ; Concise Report ; Connective tissue diseases ; Dermatology ; Diagnosis ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Linear Models ; Male ; Medical sciences ; Microscopic Angioscopy - instrumentation ; Middle Aged ; Morphology ; Nail Diseases - pathology ; nailfold capillary microscopy ; ophthalmoscope ; Ophthalmoscopes ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Patients ; Point-of-Care Systems ; Predictive Value of Tests ; Prospective Studies ; Raynaud disease ; Raynaud Disease - diagnosis ; Raynaud Disease - etiology ; Raynaud's disease ; Raynaud's phenomenon ; Rheumatology</subject><ispartof>Annals of the rheumatic diseases, 2001-04, Vol.60 (4), p.407-409</ispartof><rights>Annals of the Rheumatic Diseases</rights><rights>2001 INIST-CNRS</rights><rights>COPYRIGHT 2001 BMJ Publishing Group Ltd.</rights><rights>Copyright: 2001 Annals of the Rheumatic Diseases</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b581t-2d0a1034e22d0464f0ed0c6cde5870044101b49ff546d6be70484dcf1b261a403</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1753600/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1753600/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=929167$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11247874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anders, H J</creatorcontrib><creatorcontrib>Sigl, T</creatorcontrib><creatorcontrib>Schattenkirchner, M</creatorcontrib><title>Differentiation between primary and secondary Raynaud's phenomenon: a prospective study comparing nailfold capillaroscopy using an ophthalmoscope or stereomicroscope</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>BACKGROUND Nailfold capillary microscopy is a routine procedure in the investigation of patients with Raynaud's phenomenon (RP). As a standard method, nailfold capillary morphology is inspected with a stereomicroscope to look for capillary abnormalities such as giant loops, avascular areas, and bushy capillaries, which have all been found to be associated with certain connective tissue diseases. AIM To investigate prospectively whether nailfold capillary inspection using an ophthalmoscope is of equivalent diagnostic value to standard nailfold capillary microscopy. METHOD All the fingers of 26 patients with RP were examined in a blinded fashion and compared with the final diagnosis one month later. RESULTS All giant loops, large avascular areas, and bushy capillaries were identified by both methods. The correlation for moderate avascular areas and crossed capillaries was 0.93 and 0.955 respectively. The correlation for minor abnormalities that do not contribute to the differentiation between primary and secondary RP was 0.837 and 0.861 respectively. All patients were classified identically by the two methods. CONCLUSION For the evaluation of patients with RP, nailfold capillary morphology can reliably be assessed with an ophthalmoscope.</description><subject>Biological and medical sciences</subject><subject>Blood vessels</subject><subject>Concise Report</subject><subject>Connective tissue diseases</subject><subject>Dermatology</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopic Angioscopy - instrumentation</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Nail Diseases - pathology</subject><subject>nailfold capillary microscopy</subject><subject>ophthalmoscope</subject><subject>Ophthalmoscopes</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Patients</subject><subject>Point-of-Care Systems</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Raynaud disease</subject><subject>Raynaud Disease - diagnosis</subject><subject>Raynaud Disease - etiology</subject><subject>Raynaud's disease</subject><subject>Raynaud's phenomenon</subject><subject>Rheumatology</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kl2L1DAUhoso7rp657UEBPfGjkknTVovhHX8WGFRED8uQ5qczmRsk5q0q_OD_J-ecYbZVRYJIR_n4c05b06WPWR0xthcPNPRzgSd8Rmn8lZ2zLio8oIKejs7ppTOc14LeZTdS2mNR1qx6m52xFjBZSX5cfbrlWtbiOBHp0cXPGlg_AHgyRBdr-OGaG9JAhO83Z4-6o3Xkz1NZFiBDz1O_5xopEMawIzuEkgaJ7shJvSDjs4videua0NnidGD6zqNqAnDhkxpG9WehGE1rnTX_7kHEiJKYEqhd2bHwv3sTqu7BA_260n2-c3rT4vz_OLD23eLs4u8KSs25oWlmtE5hwJ3XPCWgqVGGAtlJSnlnFHW8LptSy6saEBSXnFrWtYUgmlO5yfZi53uMDU9WIO2RN2pvRcqaKf-jni3UstwqZgs54JuBZ7sBWL4PkEaVe-SAazaQ5iSkqIWoqAMwcf_gOswRY_FoZaUFS9EuZV7uqOWugPlfBvwVbMED_h48NA6vD6ThaxqWleI5zfgOCyglzfxe_mtzylCe6iUUbVtLoXNpQRVXGFzIf7oujtX8L6brhWlk9FdG7U3Lh24uqiZkFdZOvzmn4eojt8URmWp3n9ZoObXUhbnL1WB_OmOb_r1_xP8DbB094k</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Anders, H J</creator><creator>Sigl, T</creator><creator>Schattenkirchner, M</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>BMJ</general><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20010401</creationdate><title>Differentiation between primary and secondary Raynaud's phenomenon: a prospective study comparing nailfold capillaroscopy using an ophthalmoscope or stereomicroscope</title><author>Anders, H J ; Sigl, T ; Schattenkirchner, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b581t-2d0a1034e22d0464f0ed0c6cde5870044101b49ff546d6be70484dcf1b261a403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Blood vessels</topic><topic>Concise Report</topic><topic>Connective tissue diseases</topic><topic>Dermatology</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopic Angioscopy - instrumentation</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>Nail Diseases - pathology</topic><topic>nailfold capillary microscopy</topic><topic>ophthalmoscope</topic><topic>Ophthalmoscopes</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Patients</topic><topic>Point-of-Care Systems</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Raynaud disease</topic><topic>Raynaud Disease - diagnosis</topic><topic>Raynaud Disease - etiology</topic><topic>Raynaud's disease</topic><topic>Raynaud's phenomenon</topic><topic>Rheumatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anders, H J</creatorcontrib><creatorcontrib>Sigl, T</creatorcontrib><creatorcontrib>Schattenkirchner, M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anders, H J</au><au>Sigl, T</au><au>Schattenkirchner, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differentiation between primary and secondary Raynaud's phenomenon: a prospective study comparing nailfold capillaroscopy using an ophthalmoscope or stereomicroscope</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>60</volume><issue>4</issue><spage>407</spage><epage>409</epage><pages>407-409</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>BACKGROUND Nailfold capillary microscopy is a routine procedure in the investigation of patients with Raynaud's phenomenon (RP). As a standard method, nailfold capillary morphology is inspected with a stereomicroscope to look for capillary abnormalities such as giant loops, avascular areas, and bushy capillaries, which have all been found to be associated with certain connective tissue diseases. AIM To investigate prospectively whether nailfold capillary inspection using an ophthalmoscope is of equivalent diagnostic value to standard nailfold capillary microscopy. METHOD All the fingers of 26 patients with RP were examined in a blinded fashion and compared with the final diagnosis one month later. RESULTS All giant loops, large avascular areas, and bushy capillaries were identified by both methods. The correlation for moderate avascular areas and crossed capillaries was 0.93 and 0.955 respectively. The correlation for minor abnormalities that do not contribute to the differentiation between primary and secondary RP was 0.837 and 0.861 respectively. All patients were classified identically by the two methods. CONCLUSION For the evaluation of patients with RP, nailfold capillary morphology can reliably be assessed with an ophthalmoscope.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><pmid>11247874</pmid><doi>10.1136/ard.60.4.407</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of the rheumatic diseases, 2001-04, Vol.60 (4), p.407-409 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Blood vessels Concise Report Connective tissue diseases Dermatology Diagnosis Female Humans Investigative techniques, diagnostic techniques (general aspects) Linear Models Male Medical sciences Microscopic Angioscopy - instrumentation Middle Aged Morphology Nail Diseases - pathology nailfold capillary microscopy ophthalmoscope Ophthalmoscopes Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Patients Point-of-Care Systems Predictive Value of Tests Prospective Studies Raynaud disease Raynaud Disease - diagnosis Raynaud Disease - etiology Raynaud's disease Raynaud's phenomenon Rheumatology |
| title | Differentiation between primary and secondary Raynaud's phenomenon: a prospective study comparing nailfold capillaroscopy using an ophthalmoscope or stereomicroscope |
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