Treatment of active rheumatoid arthritis with leflunomide: two year follow up of a double blind, placebo controlled trial versus sulfasalazine

OBJECTIVE Recent studies have demonstrated the short term efficacy of leflunomide. This study evaluates the efficacy and safety of leflunomide and sulfasalazine in rheumatoid arthritis over a two year follow up period. METHODS 358 patients with rheumatoid arthritis in a double blind trial were rando...

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Veröffentlicht in:	Annals of the rheumatic diseases 2001-10, Vol.60 (10), p.913-923
Hauptverfasser:	Scott, D L, Smolen, J S, Kalden, J R, van de Putte, L B A, Larsen, A, Kvien, T K, Schattenkirchner, M, Nash, P, Oed, C, Loew-Friedrich, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - diagnostic imaging Arthritis, Rheumatoid - drug therapy Biological and medical sciences Blood Sedimentation Bones, joints and connective tissue. Antiinflammatory agents C-Reactive Protein - analysis Confidence Intervals Disability Evaluation Disease Progression Double-Blind Method Drug dosages Extended Report Female Humans Isoxazoles - therapeutic use Leflunomide Logistic Models Male Medical sciences Middle Aged Mortality Pharmacology. Drug treatments Radiography randomised trials Rheumatoid arthritis Rheumatoid Factor - blood Statistics, Nonparametric sulfasalazine Sulfasalazine - therapeutic use Treatment Outcome
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