Thrombin receptor mediated signals induce expressions of interleukin 6 and granulocyte colony stimulating factor via NF-κB activation in synovial fibroblasts

OBJECTIVE To clarify the mechanism of thrombin receptor mediated signal transduction and the induction of cytokines by thrombin stimulation in rheumatoid synovial fibroblasts. METHODS Cytokines were measured by enzyme linked immunosorbent assay (ELISA) in the supernatants of cultured rheumatoid syno...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of the rheumatic diseases 1999-01, Vol.58 (1), p.55-60
Hauptverfasser:	Shin, Hiroshi, Kitajima, Isao, Nakajima, Toshihiro, Shao, Qing, Tokioka, Takeshi, Takasaki, Ikuko, Hanyu, Naohiro, Kubo, Toshikazu, Maruyama, Ikuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - metabolism Biological and medical sciences Cell Culture Techniques cytokine Cytokines - metabolism Diseases of the osteoarticular system Extended Reports Female Fibroblasts - metabolism Gene Expression Regulation Granulocyte Colony-Stimulating Factor - genetics Granulocyte Colony-Stimulating Factor - metabolism Humans Inflammatory joint diseases Interleukin-6 - genetics Interleukin-6 - metabolism Male Medical sciences Middle Aged NF-kappa B - metabolism NF-κB Receptors, Thrombin - physiology RNA, Messenger - genetics Signal Transduction - physiology synovial cells Synovial Membrane - metabolism thrombin Translocation, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!