Essential role of chromatin assembly factor-1-mediated rapid nucleosome assembly for DNA replication and cell division in vertebrate cells

Chromatin assembly factor-1 (CAF-1), a complex consisting of p150, p60, and p48 subunits, is highly conserved from yeast to humans and facilitates nucleosome assembly of newly replicated DNA in vitro. To investigate roles of CAF-1 in vertebrates, we generated two conditional DT40 mutants, respective...

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Veröffentlicht in:	Molecular biology of the cell 2007-01, Vol.18 (1), p.129-141
Hauptverfasser:	Takami, Yasunari, Ono, Tatsuya, Fukagawa, Tatsuo, Shibahara, Kei-ichi, Nakayama, Tatsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival Centrosome - metabolism Checkpoint Kinase 1 Chickens Chromatin Assembly Factor-1 Chromosomal Proteins, Non-Histone - deficiency Chromosomal Proteins, Non-Histone - metabolism DNA Replication DNA-Binding Proteins - deficiency DNA-Binding Proteins - metabolism Enzyme Activation Gene Targeting Humans Mitosis Nucleosomes - metabolism Proliferating Cell Nuclear Antigen - metabolism Protein Binding Protein Kinases - metabolism Protein Subunits - metabolism S Phase Spindle Apparatus - metabolism Vertebrates - metabolism
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