An animal model for allergic penicilliosis induced by the intranasal instillation of viable Penicillium chrysogenum conidia

BACKGROUND A study was undertaken to determine the consequences of long term intranasal instillation of Penicillium chrysogenum propagules in a mouse model. METHODS C57 Black/6 mice were inoculated intranasally each week for six weeks with 104 viable and non-viable P chrysogenum conidia. Cytokine le...

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Veröffentlicht in:	Thorax 2000-06, Vol.55 (6), p.489-496
Hauptverfasser:	Cooley, J D, Wong, W C, Jumper, C A, Hutson, J C, Williams, H J, Schwab, C J, Straus, D C
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Allergens Allergies Animals Bronchoalveolar Lavage Fluid - immunology Cellulose acetate Cytokines Eosinophils - immunology Female Immunoglobulin E - blood Immunoglobulin E - immunology Immunoglobulin G - blood Immunoglobulins Indoor air quality Interferon-gamma - immunology Interleukin-4 - immunology Laboratory animals Lungs Lymphocytes Mice Mice, Inbred C57BL Original Penicillium chrysogenum - immunology Proteins Sick building syndrome Sick Building Syndrome - etiology Time Factors
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