Intimin from enteropathogenic Escherichia coli restores murine virulence to a Citrobacter rodentium eaeA mutant: induction of an immunoglobulin A response to intimin and EspB

The formation of attaching and effacing (A/E) lesions is central to the pathogenesis of enteropathogenic Escherichia coli (EPEC)-mediated disease in humans and Citrobacter rodentium (formerly C. freundii biotype 4280)-mediated transmissible colonic hyperplasia in mice. Closely related outer membrane...

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Veröffentlicht in:	Infection and Immunity 1996-12, Vol.64 (12), p.5315-5325
Hauptverfasser:	Frankel, G. (Imperial College of Science, London, UK.), Phillips, A.D, Novakova, M, Field, H, Candy, D.C.A, Schauer, D.B, Douce, G, Dougan, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial Analysis of the immune response. Humoral and cellular immunity Animals Antibodies, Bacterial - biosynthesis Antibody production Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Bacterial Outer Membrane Proteins - toxicity Biological and medical sciences Carrier Proteins Citrobacter - genetics Citrobacter - immunology Citrobacter - pathogenicity Citrobacter rodentium Colon - microbiology Colon - pathology ESCHERICHIA COLI Escherichia coli - metabolism Escherichia coli Proteins Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Hyperplasia Immunobiology Immunoglobulin A - biosynthesis IMMUNOGLOBULINE INMUNOGLOBULINA Mice Mutation PROTEINAS PROTEINE
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