Brittle asthma
We believe that the asthma phenotypes we have defined as types 1 and 2 brittle asthma appear to be defined subgroups of asthma. For example, we have characterised patients with type 1 brittle asthma, as defined in this review, on the basis of peak flow variability and treatment and these patients re...
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| Veröffentlicht in: | Thorax 1998-04, Vol.53 (4), p.315-321 |
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| container_title | Thorax |
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| creator | Ayres, Jon G Miles, Jon F Barnes, Peter J |
| description | We believe that the asthma phenotypes we have defined as types 1 and 2 brittle asthma appear to be defined subgroups of asthma. For example, we have characterised patients with type 1 brittle asthma, as defined in this review, on the basis of peak flow variability and treatment and these patients remain a separate group when assessed by other means such as psychosocial factors, immunoglobulin levels, and atopy. The question remains as to whether they are truly separate groups with entirely different pathogenetic influences or whether they simply represent the severe end of the spectrum. Our suggested classification into types 1 and 2 forms a useful start for studies of this condition, although prospective evaluation of patients with severe asthma is the only way of substantiating the validity of these definitions which will then enable investigation of possible mechanisms. However, these patients are rare and in order to study them as a group a national register would need to be set up along the lines of the West Midlands Brittle Asthma Register, perhaps recruiting all "at risk" patients and then using this resource as a means of exploring the different asthma phenotypes within this broad grouping, including brittle asthma. |
| doi_str_mv | 10.1136/thx.53.4.315 |
| format | Article |
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For example, we have characterised patients with type 1 brittle asthma, as defined in this review, on the basis of peak flow variability and treatment and these patients remain a separate group when assessed by other means such as psychosocial factors, immunoglobulin levels, and atopy. The question remains as to whether they are truly separate groups with entirely different pathogenetic influences or whether they simply represent the severe end of the spectrum. Our suggested classification into types 1 and 2 forms a useful start for studies of this condition, although prospective evaluation of patients with severe asthma is the only way of substantiating the validity of these definitions which will then enable investigation of possible mechanisms. However, these patients are rare and in order to study them as a group a national register would need to be set up along the lines of the West Midlands Brittle Asthma Register, perhaps recruiting all "at risk" patients and then using this resource as a means of exploring the different asthma phenotypes within this broad grouping, including brittle asthma.</description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thx.53.4.315</identifier><identifier>PMID: 9741378</identifier><identifier>CODEN: THORA7</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Thoracic Society</publisher><subject>Anti-Asthmatic Agents - therapeutic use ; Asthma ; Asthma - classification ; Asthma - epidemiology ; Asthma - physiopathology ; Asthma - therapy ; Biological and medical sciences ; Chronic obstructive pulmonary disease, asthma ; Classification ; Epidemiology ; Humans ; Medical sciences ; Occasional Review ; Patient admissions ; Peak Expiratory Flow Rate ; Phenotype ; Pneumology ; Risk Factors ; Steroids ; Studies ; Terminology as Topic</subject><ispartof>Thorax, 1998-04, Vol.53 (4), p.315-321</ispartof><rights>British Thoracic Society</rights><rights>1998 INIST-CNRS</rights><rights>Copyright: 1998 British Thoracic Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b506t-36c112b6f446358b87516be6fb766fc59ed096e42f2cb864b294fc3f1f6caaf43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1745199/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1745199/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2230116$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9741378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ayres, Jon G</creatorcontrib><creatorcontrib>Miles, Jon F</creatorcontrib><creatorcontrib>Barnes, Peter J</creatorcontrib><title>Brittle asthma</title><title>Thorax</title><addtitle>Thorax</addtitle><description>We believe that the asthma phenotypes we have defined as types 1 and 2 brittle asthma appear to be defined subgroups of asthma. For example, we have characterised patients with type 1 brittle asthma, as defined in this review, on the basis of peak flow variability and treatment and these patients remain a separate group when assessed by other means such as psychosocial factors, immunoglobulin levels, and atopy. The question remains as to whether they are truly separate groups with entirely different pathogenetic influences or whether they simply represent the severe end of the spectrum. Our suggested classification into types 1 and 2 forms a useful start for studies of this condition, although prospective evaluation of patients with severe asthma is the only way of substantiating the validity of these definitions which will then enable investigation of possible mechanisms. However, these patients are rare and in order to study them as a group a national register would need to be set up along the lines of the West Midlands Brittle Asthma Register, perhaps recruiting all "at risk" patients and then using this resource as a means of exploring the different asthma phenotypes within this broad grouping, including brittle asthma.</description><subject>Anti-Asthmatic Agents - therapeutic use</subject><subject>Asthma</subject><subject>Asthma - classification</subject><subject>Asthma - epidemiology</subject><subject>Asthma - physiopathology</subject><subject>Asthma - therapy</subject><subject>Biological and medical sciences</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Classification</subject><subject>Epidemiology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Occasional Review</subject><subject>Patient admissions</subject><subject>Peak Expiratory Flow Rate</subject><subject>Phenotype</subject><subject>Pneumology</subject><subject>Risk Factors</subject><subject>Steroids</subject><subject>Studies</subject><subject>Terminology as Topic</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp90M1LXDEUBfBQLHbUunIrCIpu-qa5L8nNy6ago7YFsYupbkMSk84b34dN3hT97xuZYVAXrrI4Pw43h5A9oGMAhl-H2eNYsDEfMxAfyAg4VgUrFW6QEaWcFsgkfiJbKc0ppRWA3CSbSnJgshqR3bNYD0PjD0waZq3ZIR-DaZL_vHq3yc3lxe_Jj-Lq1_efk9OrwgqKQ8HQAZQWA-fIRGUrKQCtx2AlYnBC-Tuq0PMylM5WyG2peHAsQEBnTOBsm3xb9j4sbOvvnO-GaBr9EOvWxCfdm1q_Trp6pv_0_zRILkCpXHC8Koj934VPg27r5HzTmM73i6QlU7RiVGZ4-AbO-0Xs8udyVwUq7wAsqy9L5WKfUvRhfQpQ_byyzitrwTTXeeXM91-ev8arWXN-tMpNcqYJ0XSuTmtWlowCYGbFktVp8I_r2MR7jZJJoa9vJxrPJVzy6VRPsz9ZetvO3z_wP_6AntA</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>Ayres, Jon G</creator><creator>Miles, Jon F</creator><creator>Barnes, Peter J</creator><general>BMJ Publishing Group Ltd and British Thoracic Society</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19980401</creationdate><title>Brittle asthma</title><author>Ayres, Jon G ; Miles, Jon F ; Barnes, Peter J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b506t-36c112b6f446358b87516be6fb766fc59ed096e42f2cb864b294fc3f1f6caaf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anti-Asthmatic Agents - therapeutic use</topic><topic>Asthma</topic><topic>Asthma - classification</topic><topic>Asthma - epidemiology</topic><topic>Asthma - physiopathology</topic><topic>Asthma - therapy</topic><topic>Biological and medical sciences</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Classification</topic><topic>Epidemiology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Occasional Review</topic><topic>Patient admissions</topic><topic>Peak Expiratory Flow Rate</topic><topic>Phenotype</topic><topic>Pneumology</topic><topic>Risk Factors</topic><topic>Steroids</topic><topic>Studies</topic><topic>Terminology as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ayres, Jon G</creatorcontrib><creatorcontrib>Miles, Jon F</creatorcontrib><creatorcontrib>Barnes, Peter J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Thorax</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ayres, Jon G</au><au>Miles, Jon F</au><au>Barnes, Peter J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brittle asthma</atitle><jtitle>Thorax</jtitle><addtitle>Thorax</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>53</volume><issue>4</issue><spage>315</spage><epage>321</epage><pages>315-321</pages><issn>0040-6376</issn><eissn>1468-3296</eissn><coden>THORA7</coden><abstract>We believe that the asthma phenotypes we have defined as types 1 and 2 brittle asthma appear to be defined subgroups of asthma. For example, we have characterised patients with type 1 brittle asthma, as defined in this review, on the basis of peak flow variability and treatment and these patients remain a separate group when assessed by other means such as psychosocial factors, immunoglobulin levels, and atopy. The question remains as to whether they are truly separate groups with entirely different pathogenetic influences or whether they simply represent the severe end of the spectrum. Our suggested classification into types 1 and 2 forms a useful start for studies of this condition, although prospective evaluation of patients with severe asthma is the only way of substantiating the validity of these definitions which will then enable investigation of possible mechanisms. However, these patients are rare and in order to study them as a group a national register would need to be set up along the lines of the West Midlands Brittle Asthma Register, perhaps recruiting all "at risk" patients and then using this resource as a means of exploring the different asthma phenotypes within this broad grouping, including brittle asthma.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Thoracic Society</pub><pmid>9741378</pmid><doi>10.1136/thx.53.4.315</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Anti-Asthmatic Agents - therapeutic use Asthma Asthma - classification Asthma - epidemiology Asthma - physiopathology Asthma - therapy Biological and medical sciences Chronic obstructive pulmonary disease, asthma Classification Epidemiology Humans Medical sciences Occasional Review Patient admissions Peak Expiratory Flow Rate Phenotype Pneumology Risk Factors Steroids Studies Terminology as Topic |
| title | Brittle asthma |
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