Therapeutic impact of percutaneous spinal biopsy in spinal infection
Objective: To investigate the therapeutic impact of percutaneous spinal biopsy in patients with suspected spinal infection. Design and patients: A review of the case notes and imaging features of 36 patients who underwent percutaneous spinal biopsy was performed. From this group 20 patients with a p...
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| Veröffentlicht in: | Postgraduate medical journal 2004-10, Vol.80 (948), p.607-609 |
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| creator | Rankine, J J Barron, D A Robinson, P Millner, P A Dickson, R A |
| description | Objective: To investigate the therapeutic impact of percutaneous spinal biopsy in patients with suspected spinal infection. Design and patients: A review of the case notes and imaging features of 36 patients who underwent percutaneous spinal biopsy was performed. From this group 20 patients with a prebiopsy diagnosis of spinal osteomyelitis were identified. Management before biopsy was noted including the use of antimicrobial therapy. The results of the histology and microbiology were noted along with the subsequent diagnosis and management. Results: Eight of the 20 patients (40%) had received antibiotics before the biopsy. An organism was isolated in 8/20 cases (40%). Of the eight patients on antibiotics, two grew an organism (25%), including one case of candida in a patient receiving flucloxacillin. Out of 12 patients not on antibiotics there were six cases where an organism was isolated (50%). The result of the biopsy led to a change in management in seven of the 20 patients (35%). Conclusions: Many clinicians are treating spinal osteomyelitis empirically with antibiotics before biopsy, but this reduces the chance of isolating an organism and determining antibiotic sensitivity. Despite this biopsy led to a change in management in 35% of cases. |
| doi_str_mv | 10.1136/pgmj.2003.017863 |
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Design and patients: A review of the case notes and imaging features of 36 patients who underwent percutaneous spinal biopsy was performed. From this group 20 patients with a prebiopsy diagnosis of spinal osteomyelitis were identified. Management before biopsy was noted including the use of antimicrobial therapy. The results of the histology and microbiology were noted along with the subsequent diagnosis and management. Results: Eight of the 20 patients (40%) had received antibiotics before the biopsy. An organism was isolated in 8/20 cases (40%). Of the eight patients on antibiotics, two grew an organism (25%), including one case of candida in a patient receiving flucloxacillin. Out of 12 patients not on antibiotics there were six cases where an organism was isolated (50%). The result of the biopsy led to a change in management in seven of the 20 patients (35%). Conclusions: Many clinicians are treating spinal osteomyelitis empirically with antibiotics before biopsy, but this reduces the chance of isolating an organism and determining antibiotic sensitivity. Despite this biopsy led to a change in management in 35% of cases.</description><identifier>ISSN: 0032-5473</identifier><identifier>EISSN: 1469-0756</identifier><identifier>DOI: 10.1136/pgmj.2003.017863</identifier><identifier>PMID: 15466997</identifier><language>eng</language><publisher>London: The Fellowship of Postgraduate Medicine</publisher><subject>Adolescent ; Adult ; Aged ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Bacterial Infections - drug therapy ; Bacterial Infections - pathology ; Bacteriology ; Biological and medical sciences ; Biopsy ; Biopsy, Needle - methods ; Candida ; Chemotherapy ; Child ; Child, Preschool ; Disease ; Family medical history ; Female ; General aspects ; Histology ; Humans ; Infant ; infection ; Infections ; Laboratories ; magnetic resonance imaging ; Male ; Medical imaging ; Medical sciences ; Microscopy ; Middle Aged ; Original ; Pathology ; Proteins ; Retrospective Studies ; Spinal Diseases - drug therapy ; Spinal Diseases - pathology ; spine ; Spine - pathology ; Studies ; Substance abuse treatment ; Surgery ; Tomography ; Tuberculosis</subject><ispartof>Postgraduate medical journal, 2004-10, Vol.80 (948), p.607-609</ispartof><rights>Copyright 2004 The Fellowship of Postgraduate Medicine</rights><rights>2004 INIST-CNRS</rights><rights>Copyright: 2004 Copyright 2004 The Fellowship of Postgraduate Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b621t-6a155e450929c13051257d17a7b91a75799f28bd99695497e327fe79ac2266cb3</citedby><cites>FETCH-LOGICAL-b621t-6a155e450929c13051257d17a7b91a75799f28bd99695497e327fe79ac2266cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1743113/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1743113/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16206546$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15466997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rankine, J J</creatorcontrib><creatorcontrib>Barron, D A</creatorcontrib><creatorcontrib>Robinson, P</creatorcontrib><creatorcontrib>Millner, P A</creatorcontrib><creatorcontrib>Dickson, R A</creatorcontrib><title>Therapeutic impact of percutaneous spinal biopsy in spinal infection</title><title>Postgraduate medical journal</title><addtitle>Postgrad Med J</addtitle><description>Objective: To investigate the therapeutic impact of percutaneous spinal biopsy in patients with suspected spinal infection. Design and patients: A review of the case notes and imaging features of 36 patients who underwent percutaneous spinal biopsy was performed. From this group 20 patients with a prebiopsy diagnosis of spinal osteomyelitis were identified. Management before biopsy was noted including the use of antimicrobial therapy. The results of the histology and microbiology were noted along with the subsequent diagnosis and management. Results: Eight of the 20 patients (40%) had received antibiotics before the biopsy. An organism was isolated in 8/20 cases (40%). Of the eight patients on antibiotics, two grew an organism (25%), including one case of candida in a patient receiving flucloxacillin. Out of 12 patients not on antibiotics there were six cases where an organism was isolated (50%). The result of the biopsy led to a change in management in seven of the 20 patients (35%). Conclusions: Many clinicians are treating spinal osteomyelitis empirically with antibiotics before biopsy, but this reduces the chance of isolating an organism and determining antibiotic sensitivity. Despite this biopsy led to a change in management in 35% of cases.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Bacterial Infections - drug therapy</subject><subject>Bacterial Infections - pathology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Biopsy, Needle - methods</subject><subject>Candida</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Disease</subject><subject>Family medical history</subject><subject>Female</subject><subject>General aspects</subject><subject>Histology</subject><subject>Humans</subject><subject>Infant</subject><subject>infection</subject><subject>Infections</subject><subject>Laboratories</subject><subject>magnetic resonance imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>Microscopy</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Pathology</subject><subject>Proteins</subject><subject>Retrospective Studies</subject><subject>Spinal Diseases - drug therapy</subject><subject>Spinal Diseases - pathology</subject><subject>spine</subject><subject>Spine - pathology</subject><subject>Studies</subject><subject>Substance abuse treatment</subject><subject>Surgery</subject><subject>Tomography</subject><subject>Tuberculosis</subject><issn>0032-5473</issn><issn>1469-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc1v1DAQxS1ERZfCnROKhMoFZfH4M75UostHkRa4FLQ3y_E6rZckDnaC6H-PV1la4NKTpXm_eZ6Zh9AzwEsAKl4PV91uSTCmSwyyEvQBWgATqsSSi4dokQVScibpMXqc0g5joJLBI3QMnAmhlFygt5fXLprBTaO3he8GY8ciNMXgop1G07swpSINvjdtUfswpJvC938Kvm-cHX3on6CjxrTJPT28J-jr-3eXq4ty_eXDx9WbdVkLAmMpDHDuGMeKKAsUcyBcbkEaWSswkkulGlLVW6WE4kxJR4lsnFTGEiKErekJOpt9h6nu3Na6foym1UP0nYk3Ohiv_1V6f62vwk8NktF8sGzw8mAQw4_JpVF3PlnXtvOmOh-FKa6qe0GCgQhJRAZf_AfuwhTzdVL-tAKuKBaQKTxTNoaUomtuZwas90nqfZJ6n6Sek8wtz__e9a7hEF0GTg-ASda0TTS99emOEwSLzGaunDmfRvfrVjfxuxaSSq4_f1vpzXrNNtXmkz7P_KuZr_NE9475G7n-wxc</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Rankine, J J</creator><creator>Barron, D A</creator><creator>Robinson, P</creator><creator>Millner, P A</creator><creator>Dickson, R A</creator><general>The Fellowship of Postgraduate Medicine</general><general>BMJ</general><general>Oxford University Press</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20041001</creationdate><title>Therapeutic impact of percutaneous spinal biopsy in spinal infection</title><author>Rankine, J J ; Barron, D A ; Robinson, P ; Millner, P A ; Dickson, R A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b621t-6a155e450929c13051257d17a7b91a75799f28bd99695497e327fe79ac2266cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Bacterial Infections - drug therapy</topic><topic>Bacterial Infections - pathology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Biopsy, Needle - methods</topic><topic>Candida</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Disease</topic><topic>Family medical history</topic><topic>Female</topic><topic>General aspects</topic><topic>Histology</topic><topic>Humans</topic><topic>Infant</topic><topic>infection</topic><topic>Infections</topic><topic>Laboratories</topic><topic>magnetic resonance imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical sciences</topic><topic>Microscopy</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Pathology</topic><topic>Proteins</topic><topic>Retrospective Studies</topic><topic>Spinal Diseases - drug therapy</topic><topic>Spinal Diseases - pathology</topic><topic>spine</topic><topic>Spine - pathology</topic><topic>Studies</topic><topic>Substance abuse treatment</topic><topic>Surgery</topic><topic>Tomography</topic><topic>Tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rankine, J J</creatorcontrib><creatorcontrib>Barron, D A</creatorcontrib><creatorcontrib>Robinson, P</creatorcontrib><creatorcontrib>Millner, P A</creatorcontrib><creatorcontrib>Dickson, R A</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Postgraduate medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rankine, J J</au><au>Barron, D A</au><au>Robinson, P</au><au>Millner, P A</au><au>Dickson, R A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic impact of percutaneous spinal biopsy in spinal infection</atitle><jtitle>Postgraduate medical journal</jtitle><addtitle>Postgrad Med J</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>80</volume><issue>948</issue><spage>607</spage><epage>609</epage><pages>607-609</pages><issn>0032-5473</issn><eissn>1469-0756</eissn><abstract>Objective: To investigate the therapeutic impact of percutaneous spinal biopsy in patients with suspected spinal infection. Design and patients: A review of the case notes and imaging features of 36 patients who underwent percutaneous spinal biopsy was performed. From this group 20 patients with a prebiopsy diagnosis of spinal osteomyelitis were identified. Management before biopsy was noted including the use of antimicrobial therapy. The results of the histology and microbiology were noted along with the subsequent diagnosis and management. Results: Eight of the 20 patients (40%) had received antibiotics before the biopsy. An organism was isolated in 8/20 cases (40%). Of the eight patients on antibiotics, two grew an organism (25%), including one case of candida in a patient receiving flucloxacillin. Out of 12 patients not on antibiotics there were six cases where an organism was isolated (50%). The result of the biopsy led to a change in management in seven of the 20 patients (35%). Conclusions: Many clinicians are treating spinal osteomyelitis empirically with antibiotics before biopsy, but this reduces the chance of isolating an organism and determining antibiotic sensitivity. Despite this biopsy led to a change in management in 35% of cases.</abstract><cop>London</cop><pub>The Fellowship of Postgraduate Medicine</pub><pmid>15466997</pmid><doi>10.1136/pgmj.2003.017863</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Anti-Bacterial Agents - therapeutic use Antibiotics Bacterial Infections - drug therapy Bacterial Infections - pathology Bacteriology Biological and medical sciences Biopsy Biopsy, Needle - methods Candida Chemotherapy Child Child, Preschool Disease Family medical history Female General aspects Histology Humans Infant infection Infections Laboratories magnetic resonance imaging Male Medical imaging Medical sciences Microscopy Middle Aged Original Pathology Proteins Retrospective Studies Spinal Diseases - drug therapy Spinal Diseases - pathology spine Spine - pathology Studies Substance abuse treatment Surgery Tomography Tuberculosis |
| title | Therapeutic impact of percutaneous spinal biopsy in spinal infection |
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