Cefuroxime induced lymphomatoid hypersensitivity reaction
An 84 year old women developed erythematous blotchy erythema and purpuric rashes over the lower limbs three days after being started on intravenous cefuroxime for acute diverticulitis. A skin biopsy specimen showed a mixed infiltrate of lymphoid cells and eosinophils; many of the lymphocytes were la...
Gespeichert in:
| Veröffentlicht in: | Postgraduate medical journal 2000-09, Vol.76 (899), p.577-579 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 579 |
|---|---|
| container_issue | 899 |
| container_start_page | 577 |
| container_title | Postgraduate medical journal |
| container_volume | 76 |
| creator | Saeed, S A M Bazza, M Zaman, M Ryatt, K S |
| description | An 84 year old women developed erythematous blotchy erythema and purpuric rashes over the lower limbs three days after being started on intravenous cefuroxime for acute diverticulitis. A skin biopsy specimen showed a mixed infiltrate of lymphoid cells and eosinophils; many of the lymphocytes were large, pleomorphic, and showed a raised mitotic rate. Immunohistochemistry showed the infiltrate to be T cell rich, with all the large cells being CD30 positive. Typical mycosis fungoides cells, marked epidermotropism, and Pautrier's abscesses were not seen. The rash disappeared 10 days after cessation of cefuroxime and the patient remained asymptomatic 15 months later. This apparent cutaneous T cell lymphoma-like reaction is best described as lymphomatoid vascular reaction. The drug induced immune response with an atypical cutaneous lymphoid infiltrate mimics a cutaneous pseudolymphoma. |
| doi_str_mv | 10.1136/pmj.76.899.577 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1741723</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4026899621</sourcerecordid><originalsourceid>FETCH-LOGICAL-b540t-ca5cf52feb67cfb4a73e7ae34d35a961f36f37f51c636da35f0c5b7e1c2cd0543</originalsourceid><addsrcrecordid>eNqF0M1P2zAYBnBrAo3Cdt0RVRoXDgl2_PE2l0mj4kuq2MS2Xi3Hsam7Js7sBNH_HqNUwE6cfHh_fv34QegLwTkhVJx1zToHkc_KMucAH9CEMFFmGLjYQxOMaZFxBvQAHca4xphQYOQjOiC4FIwUYoLKubFD8I-uMVPX1oM29XSzbbqVb1TvXT1dbTsTommj692D67fTYJTunW8_oX2rNtF83p1H6M_lxe_5dbb4cXUz_77IKs5wn2nFteWFNZUAbSumgBpQhrKaclUKYqmwFCwnWlBRK8ot1rwCQ3Sha8wZPULfxr3dUDWm1qbtg9rILrhGha30ysn_J61byXv_IEn6KxQ0Lfi6WxD8v8HEXq79ENqUOZEZmRVFai-pfFQ6-BiDsS8vECyfq5apaglCJixT1enC8dtcb_jYbQInO6CiVhsbVKtdfHUMZhRwYtnIXOzN48tYhb9SAAUub5dzuVgur-_ufv6S58mfjr5Ked7J-ASAXqXp</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781822899</pqid></control><display><type>article</type><title>Cefuroxime induced lymphomatoid hypersensitivity reaction</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Saeed, S A M ; Bazza, M ; Zaman, M ; Ryatt, K S</creator><creatorcontrib>Saeed, S A M ; Bazza, M ; Zaman, M ; Ryatt, K S</creatorcontrib><description>An 84 year old women developed erythematous blotchy erythema and purpuric rashes over the lower limbs three days after being started on intravenous cefuroxime for acute diverticulitis. A skin biopsy specimen showed a mixed infiltrate of lymphoid cells and eosinophils; many of the lymphocytes were large, pleomorphic, and showed a raised mitotic rate. Immunohistochemistry showed the infiltrate to be T cell rich, with all the large cells being CD30 positive. Typical mycosis fungoides cells, marked epidermotropism, and Pautrier's abscesses were not seen. The rash disappeared 10 days after cessation of cefuroxime and the patient remained asymptomatic 15 months later. This apparent cutaneous T cell lymphoma-like reaction is best described as lymphomatoid vascular reaction. The drug induced immune response with an atypical cutaneous lymphoid infiltrate mimics a cutaneous pseudolymphoma.</description><identifier>ISSN: 0032-5473</identifier><identifier>EISSN: 1469-0756</identifier><identifier>DOI: 10.1136/pmj.76.899.577</identifier><identifier>PMID: 10964126</identifier><language>eng</language><publisher>London: The Fellowship of Postgraduate Medicine</publisher><subject>Abdomen ; Aged ; Aged, 80 and over ; atypical cutaneous lymphomatoid infiltrate ; Biological and medical sciences ; Cardiac arrhythmia ; Case Reports ; cefuroxime ; Cefuroxime - adverse effects ; Cephalosporins - adverse effects ; cutaneous T cell lymphoma ; Diagnosis, Differential ; Diarrhea ; Drug Eruptions - diagnosis ; Drug Eruptions - etiology ; Drug toxicity and drugs side effects treatment ; Edema ; Erythema ; Female ; Fungal infections ; Humans ; Lymphocytes ; Lymphoma ; Medical sciences ; Pharmacology. Drug treatments ; Pseudolymphoma - diagnosis ; Skin Diseases - diagnosis ; Toxicity: cardiovascular system</subject><ispartof>Postgraduate medical journal, 2000-09, Vol.76 (899), p.577-579</ispartof><rights>The Fellowship of Postgraduate Medicine</rights><rights>2000 INIST-CNRS</rights><rights>Copyright: 2000 The Fellowship of Postgraduate Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b540t-ca5cf52feb67cfb4a73e7ae34d35a961f36f37f51c636da35f0c5b7e1c2cd0543</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1741723/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1741723/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1478370$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10964126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saeed, S A M</creatorcontrib><creatorcontrib>Bazza, M</creatorcontrib><creatorcontrib>Zaman, M</creatorcontrib><creatorcontrib>Ryatt, K S</creatorcontrib><title>Cefuroxime induced lymphomatoid hypersensitivity reaction</title><title>Postgraduate medical journal</title><addtitle>Postgrad Med J</addtitle><description>An 84 year old women developed erythematous blotchy erythema and purpuric rashes over the lower limbs three days after being started on intravenous cefuroxime for acute diverticulitis. A skin biopsy specimen showed a mixed infiltrate of lymphoid cells and eosinophils; many of the lymphocytes were large, pleomorphic, and showed a raised mitotic rate. Immunohistochemistry showed the infiltrate to be T cell rich, with all the large cells being CD30 positive. Typical mycosis fungoides cells, marked epidermotropism, and Pautrier's abscesses were not seen. The rash disappeared 10 days after cessation of cefuroxime and the patient remained asymptomatic 15 months later. This apparent cutaneous T cell lymphoma-like reaction is best described as lymphomatoid vascular reaction. The drug induced immune response with an atypical cutaneous lymphoid infiltrate mimics a cutaneous pseudolymphoma.</description><subject>Abdomen</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>atypical cutaneous lymphomatoid infiltrate</subject><subject>Biological and medical sciences</subject><subject>Cardiac arrhythmia</subject><subject>Case Reports</subject><subject>cefuroxime</subject><subject>Cefuroxime - adverse effects</subject><subject>Cephalosporins - adverse effects</subject><subject>cutaneous T cell lymphoma</subject><subject>Diagnosis, Differential</subject><subject>Diarrhea</subject><subject>Drug Eruptions - diagnosis</subject><subject>Drug Eruptions - etiology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Edema</subject><subject>Erythema</subject><subject>Female</subject><subject>Fungal infections</subject><subject>Humans</subject><subject>Lymphocytes</subject><subject>Lymphoma</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Pseudolymphoma - diagnosis</subject><subject>Skin Diseases - diagnosis</subject><subject>Toxicity: cardiovascular system</subject><issn>0032-5473</issn><issn>1469-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0M1P2zAYBnBrAo3Cdt0RVRoXDgl2_PE2l0mj4kuq2MS2Xi3Hsam7Js7sBNH_HqNUwE6cfHh_fv34QegLwTkhVJx1zToHkc_KMucAH9CEMFFmGLjYQxOMaZFxBvQAHca4xphQYOQjOiC4FIwUYoLKubFD8I-uMVPX1oM29XSzbbqVb1TvXT1dbTsTommj692D67fTYJTunW8_oX2rNtF83p1H6M_lxe_5dbb4cXUz_77IKs5wn2nFteWFNZUAbSumgBpQhrKaclUKYqmwFCwnWlBRK8ot1rwCQ3Sha8wZPULfxr3dUDWm1qbtg9rILrhGha30ysn_J61byXv_IEn6KxQ0Lfi6WxD8v8HEXq79ENqUOZEZmRVFai-pfFQ6-BiDsS8vECyfq5apaglCJixT1enC8dtcb_jYbQInO6CiVhsbVKtdfHUMZhRwYtnIXOzN48tYhb9SAAUub5dzuVgur-_ufv6S58mfjr5Ked7J-ASAXqXp</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Saeed, S A M</creator><creator>Bazza, M</creator><creator>Zaman, M</creator><creator>Ryatt, K S</creator><general>The Fellowship of Postgraduate Medicine</general><general>BMJ</general><general>Oxford University Press</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20000901</creationdate><title>Cefuroxime induced lymphomatoid hypersensitivity reaction</title><author>Saeed, S A M ; Bazza, M ; Zaman, M ; Ryatt, K S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b540t-ca5cf52feb67cfb4a73e7ae34d35a961f36f37f51c636da35f0c5b7e1c2cd0543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Abdomen</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>atypical cutaneous lymphomatoid infiltrate</topic><topic>Biological and medical sciences</topic><topic>Cardiac arrhythmia</topic><topic>Case Reports</topic><topic>cefuroxime</topic><topic>Cefuroxime - adverse effects</topic><topic>Cephalosporins - adverse effects</topic><topic>cutaneous T cell lymphoma</topic><topic>Diagnosis, Differential</topic><topic>Diarrhea</topic><topic>Drug Eruptions - diagnosis</topic><topic>Drug Eruptions - etiology</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Edema</topic><topic>Erythema</topic><topic>Female</topic><topic>Fungal infections</topic><topic>Humans</topic><topic>Lymphocytes</topic><topic>Lymphoma</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Pseudolymphoma - diagnosis</topic><topic>Skin Diseases - diagnosis</topic><topic>Toxicity: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saeed, S A M</creatorcontrib><creatorcontrib>Bazza, M</creatorcontrib><creatorcontrib>Zaman, M</creatorcontrib><creatorcontrib>Ryatt, K S</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Postgraduate medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saeed, S A M</au><au>Bazza, M</au><au>Zaman, M</au><au>Ryatt, K S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cefuroxime induced lymphomatoid hypersensitivity reaction</atitle><jtitle>Postgraduate medical journal</jtitle><addtitle>Postgrad Med J</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>76</volume><issue>899</issue><spage>577</spage><epage>579</epage><pages>577-579</pages><issn>0032-5473</issn><eissn>1469-0756</eissn><abstract>An 84 year old women developed erythematous blotchy erythema and purpuric rashes over the lower limbs three days after being started on intravenous cefuroxime for acute diverticulitis. A skin biopsy specimen showed a mixed infiltrate of lymphoid cells and eosinophils; many of the lymphocytes were large, pleomorphic, and showed a raised mitotic rate. Immunohistochemistry showed the infiltrate to be T cell rich, with all the large cells being CD30 positive. Typical mycosis fungoides cells, marked epidermotropism, and Pautrier's abscesses were not seen. The rash disappeared 10 days after cessation of cefuroxime and the patient remained asymptomatic 15 months later. This apparent cutaneous T cell lymphoma-like reaction is best described as lymphomatoid vascular reaction. The drug induced immune response with an atypical cutaneous lymphoid infiltrate mimics a cutaneous pseudolymphoma.</abstract><cop>London</cop><pub>The Fellowship of Postgraduate Medicine</pub><pmid>10964126</pmid><doi>10.1136/pmj.76.899.577</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0032-5473 |
| ispartof | Postgraduate medical journal, 2000-09, Vol.76 (899), p.577-579 |
| issn | 0032-5473 1469-0756 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1741723 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Abdomen Aged Aged, 80 and over atypical cutaneous lymphomatoid infiltrate Biological and medical sciences Cardiac arrhythmia Case Reports cefuroxime Cefuroxime - adverse effects Cephalosporins - adverse effects cutaneous T cell lymphoma Diagnosis, Differential Diarrhea Drug Eruptions - diagnosis Drug Eruptions - etiology Drug toxicity and drugs side effects treatment Edema Erythema Female Fungal infections Humans Lymphocytes Lymphoma Medical sciences Pharmacology. Drug treatments Pseudolymphoma - diagnosis Skin Diseases - diagnosis Toxicity: cardiovascular system |
| title | Cefuroxime induced lymphomatoid hypersensitivity reaction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T07%3A37%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cefuroxime%20induced%20lymphomatoid%20hypersensitivity%20reaction&rft.jtitle=Postgraduate%20medical%20journal&rft.au=Saeed,%20S%20A%20M&rft.date=2000-09-01&rft.volume=76&rft.issue=899&rft.spage=577&rft.epage=579&rft.pages=577-579&rft.issn=0032-5473&rft.eissn=1469-0756&rft_id=info:doi/10.1136/pmj.76.899.577&rft_dat=%3Cproquest_pubme%3E4026899621%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1781822899&rft_id=info:pmid/10964126&rfr_iscdi=true |