Urinary excretion half life of trichloroacetic acid as a biomarker of exposure to chlorinated drinking water disinfection by-products
Aims: To measure accurately urinary elimination half life of trichloroacetic acid (TCAA). Methods: A longitudinal pilot exposure/intervention study measured the elimination half life of TCAA in urine. Beverage consumption was limited to a public water supply and bottled water of known TCAA concentra...
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| Veröffentlicht in: | Occupational and environmental medicine (London, England) England), 2004-08, Vol.61 (8), p.715-716 |
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| creator | Bader, E L Hrudey, S E Froese, K L |
| description | Aims: To measure accurately urinary elimination half life of trichloroacetic acid (TCAA). Methods: A longitudinal pilot exposure/intervention study measured the elimination half life of TCAA in urine. Beverage consumption was limited to a public water supply and bottled water of known TCAA concentration, and ingestion volume was managed. The five participants limited fluid consumption to only the water provided. Consumption journals were kept by each participant and their daily first morning urine (FMU) samples were analysed for TCAA and creatinine. TCAA elimination half life curves were generated from a two week washout period using TCAA-free bottled water. Results: Individual elimination half lives ranged from 2.1 to 6.3 days, for single compartment exponential decay, the model which fit the data. Conclusion: Urinary TCAA is persistent enough to be viable as a biomarker of medium term (days) exposure to drinking water TCAA ingestion within a range of realistic concentrations. |
| doi_str_mv | 10.1136/oem.2003.008698 |
| format | Article |
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Methods: A longitudinal pilot exposure/intervention study measured the elimination half life of TCAA in urine. Beverage consumption was limited to a public water supply and bottled water of known TCAA concentration, and ingestion volume was managed. The five participants limited fluid consumption to only the water provided. Consumption journals were kept by each participant and their daily first morning urine (FMU) samples were analysed for TCAA and creatinine. TCAA elimination half life curves were generated from a two week washout period using TCAA-free bottled water. Results: Individual elimination half lives ranged from 2.1 to 6.3 days, for single compartment exponential decay, the model which fit the data. Conclusion: Urinary TCAA is persistent enough to be viable as a biomarker of medium term (days) exposure to drinking water TCAA ingestion within a range of realistic concentrations.</description><identifier>ISSN: 1351-0711</identifier><identifier>EISSN: 1470-7926</identifier><identifier>DOI: 10.1136/oem.2003.008698</identifier><identifier>PMID: 15258281</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Acids ; Adult ; Biological and medical sciences ; Biological markers ; Biomarkers ; Biomarkers - analysis ; Biomarkers - urine ; Bottled water ; Caustics - analysis ; Chemical hazards ; chlorinated disinfection by-products ; Chlorine ; DBPs ; Disinfection ; Disinfection & disinfectants ; Drinking ; Drinking water ; drinking water chlorinated disinfection by-products ; Environmental Exposure - adverse effects ; Excretion ; exposure assessment ; Female ; first morning urine void ; FMU ; Food toxicology ; HAA ; Half lives ; Half-Life ; halogenated (chloro- and bromo-) acetic acid ; Humans ; Hypothesis testing ; Ingestion ; Laboratories ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Pilot Projects ; Potable water ; Public waters ; Short Report ; solid phase microextraction ; SPME ; Studies ; TCAA ; THM ; Toxicology ; trichloroacetic acid ; Trichloroacetic Acid - urine ; trihalomethanes ; Urine ; Volunteers ; Waste byproducts ; Water consumption ; Water Intoxication - urine ; Water supply</subject><ispartof>Occupational and environmental medicine (London, England), 2004-08, Vol.61 (8), p.715-716</ispartof><rights>Occupational and Environmental Medicine</rights><rights>Copyright 2004 BMJ Publishing Group</rights><rights>2004 INIST-CNRS</rights><rights>Copyright: 2004 (c) Occupational and Environmental Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/27732326$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/27732326$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15996266$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15258281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bader, E L</creatorcontrib><creatorcontrib>Hrudey, S E</creatorcontrib><creatorcontrib>Froese, K L</creatorcontrib><title>Urinary excretion half life of trichloroacetic acid as a biomarker of exposure to chlorinated drinking water disinfection by-products</title><title>Occupational and environmental medicine (London, England)</title><addtitle>Occup Environ Med</addtitle><description>Aims: To measure accurately urinary elimination half life of trichloroacetic acid (TCAA). Methods: A longitudinal pilot exposure/intervention study measured the elimination half life of TCAA in urine. Beverage consumption was limited to a public water supply and bottled water of known TCAA concentration, and ingestion volume was managed. The five participants limited fluid consumption to only the water provided. Consumption journals were kept by each participant and their daily first morning urine (FMU) samples were analysed for TCAA and creatinine. TCAA elimination half life curves were generated from a two week washout period using TCAA-free bottled water. Results: Individual elimination half lives ranged from 2.1 to 6.3 days, for single compartment exponential decay, the model which fit the data. Conclusion: Urinary TCAA is persistent enough to be viable as a biomarker of medium term (days) exposure to drinking water TCAA ingestion within a range of realistic concentrations.</description><subject>Acids</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - urine</subject><subject>Bottled water</subject><subject>Caustics - analysis</subject><subject>Chemical hazards</subject><subject>chlorinated disinfection by-products</subject><subject>Chlorine</subject><subject>DBPs</subject><subject>Disinfection</subject><subject>Disinfection & disinfectants</subject><subject>Drinking</subject><subject>Drinking water</subject><subject>drinking water chlorinated disinfection by-products</subject><subject>Environmental Exposure - adverse effects</subject><subject>Excretion</subject><subject>exposure assessment</subject><subject>Female</subject><subject>first morning urine void</subject><subject>FMU</subject><subject>Food toxicology</subject><subject>HAA</subject><subject>Half lives</subject><subject>Half-Life</subject><subject>halogenated (chloro- and bromo-) acetic acid</subject><subject>Humans</subject><subject>Hypothesis testing</subject><subject>Ingestion</subject><subject>Laboratories</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Potable water</subject><subject>Public waters</subject><subject>Short Report</subject><subject>solid phase microextraction</subject><subject>SPME</subject><subject>Studies</subject><subject>TCAA</subject><subject>THM</subject><subject>Toxicology</subject><subject>trichloroacetic acid</subject><subject>Trichloroacetic Acid - urine</subject><subject>trihalomethanes</subject><subject>Urine</subject><subject>Volunteers</subject><subject>Waste byproducts</subject><subject>Water consumption</subject><subject>Water Intoxication - urine</subject><subject>Water supply</subject><issn>1351-0711</issn><issn>1470-7926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkkuLFDEUhQtRnHF07UoJiC6EavPoymMzII2j4qggjoKbkKSS6fRUVdokpd0_wP9teqptR1e54Xycey_nVtVDBGcIEfoi2H6GISQzCDkV_FZ1jOYM1kxgervUpEE1ZAgdVfdSWkGICCP4bnWEGtxwzNFx9esi-kHFLbAbE232YQBL1TnQeWdBcCBHb5ZdiEGZohqgjG-BSkAB7UOv4pWNO8xu1iGN0YIcwDVfTLNtQVuKKz9cgp_lG0Hrkx-cNdd99LZex9COJqf71R2numQf7N-T6uLs1efFm_r84-u3i5fntZ5zlmvcMkEo1LYhHGMOeYNxq7FTjumGMd4iYbghvHGUKMe11ZoIRV3LNeXGKXJSnU6-61H3tjV2yFF1ch19WWUrg_LyX2XwS3kZfkjE5pBjUgye7Q1i-D7alGXvk7FdpwYbxiQRRRwyIgr45D9wFcY4lOWKF0eYCoJZoR7fnOcwyJ98CvB0D6hkSi5RDcanG5wQFFNauEcTt0o5xIOOWcmb4J1eT7pP2W4OeslPUkZYIz98WUj87R1-Lz6dya-Ffz7xul_97Qbl7uhkOTq5Ozo5HR35DbrVyOo</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Bader, E L</creator><creator>Hrudey, S E</creator><creator>Froese, K L</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20040801</creationdate><title>Urinary excretion half life of trichloroacetic acid as a biomarker of exposure to chlorinated drinking water disinfection by-products</title><author>Bader, E L ; Hrudey, S E ; Froese, K L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b487t-2d79360be53822808522db2faf7b5778d19c8c385f63af8bebb39a6fd8b68cfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acids</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - urine</topic><topic>Bottled water</topic><topic>Caustics - analysis</topic><topic>Chemical hazards</topic><topic>chlorinated disinfection by-products</topic><topic>Chlorine</topic><topic>DBPs</topic><topic>Disinfection</topic><topic>Disinfection & disinfectants</topic><topic>Drinking</topic><topic>Drinking water</topic><topic>drinking water chlorinated disinfection by-products</topic><topic>Environmental Exposure - adverse effects</topic><topic>Excretion</topic><topic>exposure assessment</topic><topic>Female</topic><topic>first morning urine void</topic><topic>FMU</topic><topic>Food toxicology</topic><topic>HAA</topic><topic>Half lives</topic><topic>Half-Life</topic><topic>halogenated (chloro- and bromo-) acetic acid</topic><topic>Humans</topic><topic>Hypothesis testing</topic><topic>Ingestion</topic><topic>Laboratories</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Potable water</topic><topic>Public waters</topic><topic>Short Report</topic><topic>solid phase microextraction</topic><topic>SPME</topic><topic>Studies</topic><topic>TCAA</topic><topic>THM</topic><topic>Toxicology</topic><topic>trichloroacetic acid</topic><topic>Trichloroacetic Acid - 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Methods: A longitudinal pilot exposure/intervention study measured the elimination half life of TCAA in urine. Beverage consumption was limited to a public water supply and bottled water of known TCAA concentration, and ingestion volume was managed. The five participants limited fluid consumption to only the water provided. Consumption journals were kept by each participant and their daily first morning urine (FMU) samples were analysed for TCAA and creatinine. TCAA elimination half life curves were generated from a two week washout period using TCAA-free bottled water. Results: Individual elimination half lives ranged from 2.1 to 6.3 days, for single compartment exponential decay, the model which fit the data. Conclusion: Urinary TCAA is persistent enough to be viable as a biomarker of medium term (days) exposure to drinking water TCAA ingestion within a range of realistic concentrations.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>15258281</pmid><doi>10.1136/oem.2003.008698</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1351-0711 |
| ispartof | Occupational and environmental medicine (London, England), 2004-08, Vol.61 (8), p.715-716 |
| issn | 1351-0711 1470-7926 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection |
| subjects | Acids Adult Biological and medical sciences Biological markers Biomarkers Biomarkers - analysis Biomarkers - urine Bottled water Caustics - analysis Chemical hazards chlorinated disinfection by-products Chlorine DBPs Disinfection Disinfection & disinfectants Drinking Drinking water drinking water chlorinated disinfection by-products Environmental Exposure - adverse effects Excretion exposure assessment Female first morning urine void FMU Food toxicology HAA Half lives Half-Life halogenated (chloro- and bromo-) acetic acid Humans Hypothesis testing Ingestion Laboratories Longitudinal Studies Male Medical sciences Middle Aged Pilot Projects Potable water Public waters Short Report solid phase microextraction SPME Studies TCAA THM Toxicology trichloroacetic acid Trichloroacetic Acid - urine trihalomethanes Urine Volunteers Waste byproducts Water consumption Water Intoxication - urine Water supply |
| title | Urinary excretion half life of trichloroacetic acid as a biomarker of exposure to chlorinated drinking water disinfection by-products |
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