Mortality of employees of a perfluorooctanesulphonyl fluoride manufacturing facility
Aim: To evaluate the mortality experience of a cohort of employees of a perfluorooctanesulphonyl fluoride (POSF) based fluorochemical production facility. Methods: A retrospective cohort mortality study followed all workers with at least one year of cumulative employment at the facility. The jobs he...
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| Veröffentlicht in: | Occupational and environmental medicine (London, England) England), 2003-10, Vol.60 (10), p.722-729 |
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| creator | Alexander, B H Olsen, G W Burris, J M Mandel, J H Mandel, J S |
| description | Aim: To evaluate the mortality experience of a cohort of employees of a perfluorooctanesulphonyl fluoride (POSF) based fluorochemical production facility. Methods: A retrospective cohort mortality study followed all workers with at least one year of cumulative employment at the facility. The jobs held by cohort members were assigned to one of three exposure subgroups; high exposed, low exposed, and non-exposed, based on biological monitoring data for perfluorooctane sulphonate (PFOS). Results: A total of 145 deaths were identified in the 2083 cohort members. Sixty five deaths occurred among workers ever employed in high exposed jobs. The overall mortality rates for the cohort and the exposure subcohorts were lower than expected in the general population. Two deaths from liver cancer were observed in the workers with at least one year of high or low exposure (standardised mortality ratio (SMR) 3.08, 95% CI 0.37 to 11.10). The risk of death from bladder cancer was increased for the entire cohort (three observed, SMR 4.81, 95% CI 0.99 to 14.06). All three bladder cancers occurred among workers who held a high exposure job (SMR 12.77, 95% CI 2.63 to 37.35). The bladder cancer cases primarily worked in non-production jobs, including maintenance and incinerator and wastewater treatment plant operations. Conclusion: Workers employed in high exposure jobs had an increased number of deaths from bladder cancer; however it is not clear whether these three cases can be attributed to fluorochemical exposure, an unknown bladder carcinogen encountered during the course of maintenance work, and/or non-occupational exposures. With only three observed cases the possibility of a chance finding cannot be ruled out. |
| doi_str_mv | 10.1136/oem.60.10.722 |
| format | Article |
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Methods: A retrospective cohort mortality study followed all workers with at least one year of cumulative employment at the facility. The jobs held by cohort members were assigned to one of three exposure subgroups; high exposed, low exposed, and non-exposed, based on biological monitoring data for perfluorooctane sulphonate (PFOS). Results: A total of 145 deaths were identified in the 2083 cohort members. Sixty five deaths occurred among workers ever employed in high exposed jobs. The overall mortality rates for the cohort and the exposure subcohorts were lower than expected in the general population. Two deaths from liver cancer were observed in the workers with at least one year of high or low exposure (standardised mortality ratio (SMR) 3.08, 95% CI 0.37 to 11.10). The risk of death from bladder cancer was increased for the entire cohort (three observed, SMR 4.81, 95% CI 0.99 to 14.06). All three bladder cancers occurred among workers who held a high exposure job (SMR 12.77, 95% CI 2.63 to 37.35). The bladder cancer cases primarily worked in non-production jobs, including maintenance and incinerator and wastewater treatment plant operations. Conclusion: Workers employed in high exposure jobs had an increased number of deaths from bladder cancer; however it is not clear whether these three cases can be attributed to fluorochemical exposure, an unknown bladder carcinogen encountered during the course of maintenance work, and/or non-occupational exposures. With only three observed cases the possibility of a chance finding cannot be ruled out.</description><identifier>ISSN: 1351-0711</identifier><identifier>EISSN: 1470-7926</identifier><identifier>DOI: 10.1136/oem.60.10.722</identifier><identifier>PMID: 14504359</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Adult ; Bioassays ; Biological and medical sciences ; Biomonitoring ; bladder cancer ; Cancer ; Caprylates - adverse effects ; Cause of Death ; Causes of death ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chemical hazards ; Chemical Industry ; Chemical workers ; Chemicals ; confidence interval ; Death ; Demographic aspects ; Employment ; Environmental Monitoring - methods ; Epidemiologic Methods ; Epidemiological Monitoring ; Female ; Fluorine compounds ; Fluorocarbons - adverse effects ; fluorochemicals ; Health aspects ; Humans ; ICD ; Incinerators ; International Classification of Disease ; Liver ; Liver cancer ; Male ; Manufacturing industry ; Medical sciences ; Middle Aged ; Mortality ; N-EtFOSE ; N-ethylperfluorooctane sulphonamide alcohol ; National Death Index ; NDI ; Occupational Diseases - mortality ; Occupational exposure ; Occupational Exposure - adverse effects ; Occupational mortality ; Original ; perfluorooctane sulphonate ; perfluorooctanesulphonyl fluoride ; perfluorooctanoic acid ; perfluroroctane sulphonate ; PFOA ; PFOS ; POSF ; Rodents ; SMR ; standardised mortality ratio ; Toxicology ; Urinary bladder ; Urinary Bladder Neoplasms - chemically induced ; Urinary Bladder Neoplasms - mortality ; Various organic compounds ; Wastewater treatment plants</subject><ispartof>Occupational and environmental medicine (London, England), 2003-10, Vol.60 (10), p.722-729</ispartof><rights>Copyright 2003 Occupational and Environmental Medicine</rights><rights>Copyright 2003 BMJ Publishing Group</rights><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2003 BMJ Publishing Group Ltd.</rights><rights>Copyright: 2003 Copyright 2003 Occupational and Environmental Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b709t-588c0ebfb24615b0fa7e68920b1ba3b04752e73bdf6d6538aeb55a95be274053</citedby><cites>FETCH-LOGICAL-b709t-588c0ebfb24615b0fa7e68920b1ba3b04752e73bdf6d6538aeb55a95be274053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/27732062$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/27732062$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15139502$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14504359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alexander, B H</creatorcontrib><creatorcontrib>Olsen, G W</creatorcontrib><creatorcontrib>Burris, J M</creatorcontrib><creatorcontrib>Mandel, J H</creatorcontrib><creatorcontrib>Mandel, J S</creatorcontrib><title>Mortality of employees of a perfluorooctanesulphonyl fluoride manufacturing facility</title><title>Occupational and environmental medicine (London, England)</title><addtitle>Occup Environ Med</addtitle><description>Aim: To evaluate the mortality experience of a cohort of employees of a perfluorooctanesulphonyl fluoride (POSF) based fluorochemical production facility. Methods: A retrospective cohort mortality study followed all workers with at least one year of cumulative employment at the facility. The jobs held by cohort members were assigned to one of three exposure subgroups; high exposed, low exposed, and non-exposed, based on biological monitoring data for perfluorooctane sulphonate (PFOS). Results: A total of 145 deaths were identified in the 2083 cohort members. Sixty five deaths occurred among workers ever employed in high exposed jobs. The overall mortality rates for the cohort and the exposure subcohorts were lower than expected in the general population. Two deaths from liver cancer were observed in the workers with at least one year of high or low exposure (standardised mortality ratio (SMR) 3.08, 95% CI 0.37 to 11.10). The risk of death from bladder cancer was increased for the entire cohort (three observed, SMR 4.81, 95% CI 0.99 to 14.06). All three bladder cancers occurred among workers who held a high exposure job (SMR 12.77, 95% CI 2.63 to 37.35). The bladder cancer cases primarily worked in non-production jobs, including maintenance and incinerator and wastewater treatment plant operations. Conclusion: Workers employed in high exposure jobs had an increased number of deaths from bladder cancer; however it is not clear whether these three cases can be attributed to fluorochemical exposure, an unknown bladder carcinogen encountered during the course of maintenance work, and/or non-occupational exposures. With only three observed cases the possibility of a chance finding cannot be ruled out.</description><subject>Adult</subject><subject>Bioassays</subject><subject>Biological and medical sciences</subject><subject>Biomonitoring</subject><subject>bladder cancer</subject><subject>Cancer</subject><subject>Caprylates - adverse effects</subject><subject>Cause of Death</subject><subject>Causes of death</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chemical hazards</subject><subject>Chemical Industry</subject><subject>Chemical workers</subject><subject>Chemicals</subject><subject>confidence interval</subject><subject>Death</subject><subject>Demographic aspects</subject><subject>Employment</subject><subject>Environmental Monitoring - methods</subject><subject>Epidemiologic Methods</subject><subject>Epidemiological Monitoring</subject><subject>Female</subject><subject>Fluorine compounds</subject><subject>Fluorocarbons - adverse effects</subject><subject>fluorochemicals</subject><subject>Health aspects</subject><subject>Humans</subject><subject>ICD</subject><subject>Incinerators</subject><subject>International Classification of Disease</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Male</subject><subject>Manufacturing industry</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>N-EtFOSE</subject><subject>N-ethylperfluorooctane sulphonamide alcohol</subject><subject>National Death Index</subject><subject>NDI</subject><subject>Occupational Diseases - mortality</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational mortality</subject><subject>Original</subject><subject>perfluorooctane sulphonate</subject><subject>perfluorooctanesulphonyl fluoride</subject><subject>perfluorooctanoic acid</subject><subject>perfluroroctane sulphonate</subject><subject>PFOA</subject><subject>PFOS</subject><subject>POSF</subject><subject>Rodents</subject><subject>SMR</subject><subject>standardised mortality ratio</subject><subject>Toxicology</subject><subject>Urinary bladder</subject><subject>Urinary Bladder Neoplasms - chemically induced</subject><subject>Urinary Bladder Neoplasms - mortality</subject><subject>Various organic compounds</subject><subject>Wastewater treatment plants</subject><issn>1351-0711</issn><issn>1470-7926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFksuP0zAQhyMEYh9w5AiKhBBcUvyI7eaCtCqPBS0gUMXVstNx18Wxg52s6H-Pu426C1oJ-eDxzOffzNhTFE8wmmFM-esA3YxnG80EIfeKY1wLVImG8PvZpgxXSGB8VJyktEEIU0HJw-II1wzVlDXHxfJziINydtiWwZTQ9S5sAdLuoMoeonFjiCG0g_KQRtdfBr915bXXrqDslB-NaocxWr8us2V3Uo-KB0a5BI-n_bRYvn-3XJxXF18_fFycXVRaoGao2HzeItBGk5pjppFRAvi8IUhjrahGtWAEBNUrw1ec0bkCzZhqmAYiasToafFmL9uPuoNVC36Iysk-2k7FrQzKyr8j3l7KdbiSOF-vEc0CLyeBGH6NkAbZ2dSCc7nZMCYpakoRobTJ5PN_yE0Yo8_NZbE5JpznejJV7am1ciCtNyGnbdfgIWcPHozN7jOMERG8ISTzszv4vFbQ2fbOC1OCNoaUIphDsxjJ3TjIPA6So91RXPPPbr_QDT39fwZeTIBKrXImKt_adMMxTBuGdkJP99wmDSEe4kTkeUL8VmE2DfD7EFfxp-SCCia__FjIxSfx9tv3BZLnmX-153W3-U8PfwCCx-P-</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Alexander, B H</creator><creator>Olsen, G W</creator><creator>Burris, J M</creator><creator>Mandel, J H</creator><creator>Mandel, J S</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7QQ</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>KR7</scope><scope>5PM</scope></search><sort><creationdate>20031001</creationdate><title>Mortality of employees of a perfluorooctanesulphonyl fluoride manufacturing facility</title><author>Alexander, B H ; Olsen, G W ; Burris, J M ; Mandel, J H ; Mandel, J S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b709t-588c0ebfb24615b0fa7e68920b1ba3b04752e73bdf6d6538aeb55a95be274053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Bioassays</topic><topic>Biological and medical sciences</topic><topic>Biomonitoring</topic><topic>bladder cancer</topic><topic>Cancer</topic><topic>Caprylates - adverse effects</topic><topic>Cause of Death</topic><topic>Causes of death</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chemical hazards</topic><topic>Chemical Industry</topic><topic>Chemical workers</topic><topic>Chemicals</topic><topic>confidence interval</topic><topic>Death</topic><topic>Demographic aspects</topic><topic>Employment</topic><topic>Environmental Monitoring - methods</topic><topic>Epidemiologic Methods</topic><topic>Epidemiological Monitoring</topic><topic>Female</topic><topic>Fluorine compounds</topic><topic>Fluorocarbons - adverse effects</topic><topic>fluorochemicals</topic><topic>Health aspects</topic><topic>Humans</topic><topic>ICD</topic><topic>Incinerators</topic><topic>International Classification of Disease</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Male</topic><topic>Manufacturing industry</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>N-EtFOSE</topic><topic>N-ethylperfluorooctane sulphonamide alcohol</topic><topic>National Death Index</topic><topic>NDI</topic><topic>Occupational Diseases - mortality</topic><topic>Occupational exposure</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational mortality</topic><topic>Original</topic><topic>perfluorooctane sulphonate</topic><topic>perfluorooctanesulphonyl fluoride</topic><topic>perfluorooctanoic acid</topic><topic>perfluroroctane sulphonate</topic><topic>PFOA</topic><topic>PFOS</topic><topic>POSF</topic><topic>Rodents</topic><topic>SMR</topic><topic>standardised mortality ratio</topic><topic>Toxicology</topic><topic>Urinary bladder</topic><topic>Urinary Bladder Neoplasms - chemically induced</topic><topic>Urinary Bladder Neoplasms - mortality</topic><topic>Various organic compounds</topic><topic>Wastewater treatment plants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alexander, B H</creatorcontrib><creatorcontrib>Olsen, G W</creatorcontrib><creatorcontrib>Burris, J M</creatorcontrib><creatorcontrib>Mandel, J H</creatorcontrib><creatorcontrib>Mandel, J S</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Engineering Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Ceramic Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Occupational and environmental medicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alexander, B H</au><au>Olsen, G W</au><au>Burris, J M</au><au>Mandel, J H</au><au>Mandel, J S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mortality of employees of a perfluorooctanesulphonyl fluoride manufacturing facility</atitle><jtitle>Occupational and environmental medicine (London, England)</jtitle><addtitle>Occup Environ Med</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>60</volume><issue>10</issue><spage>722</spage><epage>729</epage><pages>722-729</pages><issn>1351-0711</issn><eissn>1470-7926</eissn><abstract>Aim: To evaluate the mortality experience of a cohort of employees of a perfluorooctanesulphonyl fluoride (POSF) based fluorochemical production facility. Methods: A retrospective cohort mortality study followed all workers with at least one year of cumulative employment at the facility. The jobs held by cohort members were assigned to one of three exposure subgroups; high exposed, low exposed, and non-exposed, based on biological monitoring data for perfluorooctane sulphonate (PFOS). Results: A total of 145 deaths were identified in the 2083 cohort members. Sixty five deaths occurred among workers ever employed in high exposed jobs. The overall mortality rates for the cohort and the exposure subcohorts were lower than expected in the general population. Two deaths from liver cancer were observed in the workers with at least one year of high or low exposure (standardised mortality ratio (SMR) 3.08, 95% CI 0.37 to 11.10). The risk of death from bladder cancer was increased for the entire cohort (three observed, SMR 4.81, 95% CI 0.99 to 14.06). All three bladder cancers occurred among workers who held a high exposure job (SMR 12.77, 95% CI 2.63 to 37.35). The bladder cancer cases primarily worked in non-production jobs, including maintenance and incinerator and wastewater treatment plant operations. Conclusion: Workers employed in high exposure jobs had an increased number of deaths from bladder cancer; however it is not clear whether these three cases can be attributed to fluorochemical exposure, an unknown bladder carcinogen encountered during the course of maintenance work, and/or non-occupational exposures. With only three observed cases the possibility of a chance finding cannot be ruled out.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>14504359</pmid><doi>10.1136/oem.60.10.722</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Occupational and environmental medicine (London, England), 2003-10, Vol.60 (10), p.722-729 |
| issn | 1351-0711 1470-7926 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Bioassays Biological and medical sciences Biomonitoring bladder cancer Cancer Caprylates - adverse effects Cause of Death Causes of death Chemical and industrial products toxicology. Toxic occupational diseases Chemical hazards Chemical Industry Chemical workers Chemicals confidence interval Death Demographic aspects Employment Environmental Monitoring - methods Epidemiologic Methods Epidemiological Monitoring Female Fluorine compounds Fluorocarbons - adverse effects fluorochemicals Health aspects Humans ICD Incinerators International Classification of Disease Liver Liver cancer Male Manufacturing industry Medical sciences Middle Aged Mortality N-EtFOSE N-ethylperfluorooctane sulphonamide alcohol National Death Index NDI Occupational Diseases - mortality Occupational exposure Occupational Exposure - adverse effects Occupational mortality Original perfluorooctane sulphonate perfluorooctanesulphonyl fluoride perfluorooctanoic acid perfluroroctane sulphonate PFOA PFOS POSF Rodents SMR standardised mortality ratio Toxicology Urinary bladder Urinary Bladder Neoplasms - chemically induced Urinary Bladder Neoplasms - mortality Various organic compounds Wastewater treatment plants |
| title | Mortality of employees of a perfluorooctanesulphonyl fluoride manufacturing facility |
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