Adverse health effects after low level exposure to organophosphates

In this edition, Pilkington et al report the results of an extensive epidemiological study of the relation between exposure to organophosphate pesticides, indices of change in peripheral nerve function, and neuropsychological abnormalities in United Kingdom sheep farmers and dippers. 5 The inevitabl...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Occupational and environmental medicine (London, England) England), 2001-11, Vol.58 (11), p.689-690
1. Verfasser: BLAIN, P G
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 690
container_issue 11
container_start_page 689
container_title Occupational and environmental medicine (London, England)
container_volume 58
creator BLAIN, P G
description In this edition, Pilkington et al report the results of an extensive epidemiological study of the relation between exposure to organophosphate pesticides, indices of change in peripheral nerve function, and neuropsychological abnormalities in United Kingdom sheep farmers and dippers. 5 The inevitable paucity of individual data on historical exposure was rectified by an ingenious method to estimate exposure. Mechanistic studies have suggested that long term effects of organophosphates may be mediated by cholinergic mechanisms or phosphorylation of neuronal protein sites, and other mechanisms may be important as genetic differences in detoxification enzymes and non-specific binding account for some of the variations between people in susceptibility to anticholinesterases.
doi_str_mv 10.1136/oem.58.11.689
format Article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1740066</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A80194116</galeid><sourcerecordid>A80194116</sourcerecordid><originalsourceid>FETCH-LOGICAL-b623t-a3876d730fe7085f7843b1bb245fd59e45d51624aec27d899c066deaa4b7f9e43</originalsourceid><addsrcrecordid>eNqFkctv1DAQhy0Eog84ckWRuHBoFjuOH7kgrVbQIi2PQ-FqOcl4kyWJU9u7lP-eqXbVgoRAPnjk-fTZ4x8hLxhdMMblGw_jQmisF1JXj8gpKxXNVVXIx1hzwXKqGDshZzFuKWVc8eIpOWFMUqoKdkpWy3YPIULWgR1Sl4Fz0KSYWZcgZIP_kQ2whyGD29nHXYAs-cyHjZ383Pk4dzZBfEaeODtEeH7cz8nX9--uV1f5-vPlh9Vyndey4Cm3XCvZKk4dKKqFU7rkNavrohSuFRWUohVMFqWFplCtrqqGStmCtWWtHLb5OXl78M67eoS2gSkFO5g59KMNP423vfmzM_Wd2fi9Yaqk6ELBq6Mg-JsdxGS2fhcmfDMimolCanFHXRyojR3A9JPzKGs2MAE6_QSux-Olpqwq8R8Rz_-C42ph7Jt_8E3wMQZw9wMwau4iNRipERprg5Ei__L3qR_oY4YPwj4muL3v2_DdSMWVMJ--rcyXq7W6vP64Nhr51we-Hrf_ufsX8m65LA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781526856</pqid></control><display><type>article</type><title>Adverse health effects after low level exposure to organophosphates</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>BLAIN, P G</creator><creatorcontrib>BLAIN, P G</creatorcontrib><description>In this edition, Pilkington et al report the results of an extensive epidemiological study of the relation between exposure to organophosphate pesticides, indices of change in peripheral nerve function, and neuropsychological abnormalities in United Kingdom sheep farmers and dippers. 5 The inevitable paucity of individual data on historical exposure was rectified by an ingenious method to estimate exposure. Mechanistic studies have suggested that long term effects of organophosphates may be mediated by cholinergic mechanisms or phosphorylation of neuronal protein sites, and other mechanisms may be important as genetic differences in detoxification enzymes and non-specific binding account for some of the variations between people in susceptibility to anticholinesterases.</description><identifier>ISSN: 1351-0711</identifier><identifier>EISSN: 1470-7926</identifier><identifier>DOI: 10.1136/oem.58.11.689</identifier><identifier>PMID: 11600721</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd</publisher><subject>Detoxification ; Epidemiology ; Health aspects ; Health risks ; Humans ; Insecticides - adverse effects ; Livestock farming ; Long term ; Metabolites ; Mortality ; Nervous System Diseases - chemically induced ; Neurotoxicity ; Occupational Diseases - chemically induced ; Occupational Exposure - adverse effects ; Organophosphates ; Organophosphorus Compounds ; Organophosphorus pesticides ; Pesticides ; Phosphates ; Poisoning ; Sheep ; Studies</subject><ispartof>Occupational and environmental medicine (London, England), 2001-11, Vol.58 (11), p.689-690</ispartof><rights>Occupational and Environmental Medicine</rights><rights>COPYRIGHT 2001 BMJ Publishing Group Ltd.</rights><rights>Copyright: 2001 Occupational and Environmental Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b623t-a3876d730fe7085f7843b1bb245fd59e45d51624aec27d899c066deaa4b7f9e43</citedby><cites>FETCH-LOGICAL-b623t-a3876d730fe7085f7843b1bb245fd59e45d51624aec27d899c066deaa4b7f9e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1740066/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1740066/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11600721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BLAIN, P G</creatorcontrib><title>Adverse health effects after low level exposure to organophosphates</title><title>Occupational and environmental medicine (London, England)</title><addtitle>Occup Environ Med</addtitle><description>In this edition, Pilkington et al report the results of an extensive epidemiological study of the relation between exposure to organophosphate pesticides, indices of change in peripheral nerve function, and neuropsychological abnormalities in United Kingdom sheep farmers and dippers. 5 The inevitable paucity of individual data on historical exposure was rectified by an ingenious method to estimate exposure. Mechanistic studies have suggested that long term effects of organophosphates may be mediated by cholinergic mechanisms or phosphorylation of neuronal protein sites, and other mechanisms may be important as genetic differences in detoxification enzymes and non-specific binding account for some of the variations between people in susceptibility to anticholinesterases.</description><subject>Detoxification</subject><subject>Epidemiology</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Humans</subject><subject>Insecticides - adverse effects</subject><subject>Livestock farming</subject><subject>Long term</subject><subject>Metabolites</subject><subject>Mortality</subject><subject>Nervous System Diseases - chemically induced</subject><subject>Neurotoxicity</subject><subject>Occupational Diseases - chemically induced</subject><subject>Occupational Exposure - adverse effects</subject><subject>Organophosphates</subject><subject>Organophosphorus Compounds</subject><subject>Organophosphorus pesticides</subject><subject>Pesticides</subject><subject>Phosphates</subject><subject>Poisoning</subject><subject>Sheep</subject><subject>Studies</subject><issn>1351-0711</issn><issn>1470-7926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkctv1DAQhy0Eog84ckWRuHBoFjuOH7kgrVbQIi2PQ-FqOcl4kyWJU9u7lP-eqXbVgoRAPnjk-fTZ4x8hLxhdMMblGw_jQmisF1JXj8gpKxXNVVXIx1hzwXKqGDshZzFuKWVc8eIpOWFMUqoKdkpWy3YPIULWgR1Sl4Fz0KSYWZcgZIP_kQ2whyGD29nHXYAs-cyHjZ383Pk4dzZBfEaeODtEeH7cz8nX9--uV1f5-vPlh9Vyndey4Cm3XCvZKk4dKKqFU7rkNavrohSuFRWUohVMFqWFplCtrqqGStmCtWWtHLb5OXl78M67eoS2gSkFO5g59KMNP423vfmzM_Wd2fi9Yaqk6ELBq6Mg-JsdxGS2fhcmfDMimolCanFHXRyojR3A9JPzKGs2MAE6_QSux-Olpqwq8R8Rz_-C42ph7Jt_8E3wMQZw9wMwau4iNRipERprg5Ei__L3qR_oY4YPwj4muL3v2_DdSMWVMJ--rcyXq7W6vP64Nhr51we-Hrf_ufsX8m65LA</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>BLAIN, P G</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>5PM</scope></search><sort><creationdate>20011101</creationdate><title>Adverse health effects after low level exposure to organophosphates</title><author>BLAIN, P G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b623t-a3876d730fe7085f7843b1bb245fd59e45d51624aec27d899c066deaa4b7f9e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Detoxification</topic><topic>Epidemiology</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Humans</topic><topic>Insecticides - adverse effects</topic><topic>Livestock farming</topic><topic>Long term</topic><topic>Metabolites</topic><topic>Mortality</topic><topic>Nervous System Diseases - chemically induced</topic><topic>Neurotoxicity</topic><topic>Occupational Diseases - chemically induced</topic><topic>Occupational Exposure - adverse effects</topic><topic>Organophosphates</topic><topic>Organophosphorus Compounds</topic><topic>Organophosphorus pesticides</topic><topic>Pesticides</topic><topic>Phosphates</topic><topic>Poisoning</topic><topic>Sheep</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BLAIN, P G</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Engineering Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Occupational and environmental medicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BLAIN, P G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adverse health effects after low level exposure to organophosphates</atitle><jtitle>Occupational and environmental medicine (London, England)</jtitle><addtitle>Occup Environ Med</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>58</volume><issue>11</issue><spage>689</spage><epage>690</epage><pages>689-690</pages><issn>1351-0711</issn><eissn>1470-7926</eissn><abstract>In this edition, Pilkington et al report the results of an extensive epidemiological study of the relation between exposure to organophosphate pesticides, indices of change in peripheral nerve function, and neuropsychological abnormalities in United Kingdom sheep farmers and dippers. 5 The inevitable paucity of individual data on historical exposure was rectified by an ingenious method to estimate exposure. Mechanistic studies have suggested that long term effects of organophosphates may be mediated by cholinergic mechanisms or phosphorylation of neuronal protein sites, and other mechanisms may be important as genetic differences in detoxification enzymes and non-specific binding account for some of the variations between people in susceptibility to anticholinesterases.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd</pub><pmid>11600721</pmid><doi>10.1136/oem.58.11.689</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1351-0711
ispartof Occupational and environmental medicine (London, England), 2001-11, Vol.58 (11), p.689-690
issn 1351-0711
1470-7926
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1740066
source MEDLINE; JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection
subjects Detoxification
Epidemiology
Health aspects
Health risks
Humans
Insecticides - adverse effects
Livestock farming
Long term
Metabolites
Mortality
Nervous System Diseases - chemically induced
Neurotoxicity
Occupational Diseases - chemically induced
Occupational Exposure - adverse effects
Organophosphates
Organophosphorus Compounds
Organophosphorus pesticides
Pesticides
Phosphates
Poisoning
Sheep
Studies
title Adverse health effects after low level exposure to organophosphates
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T09%3A46%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adverse%20health%20effects%20after%20low%20level%20exposure%20to%20organophosphates&rft.jtitle=Occupational%20and%20environmental%20medicine%20(London,%20England)&rft.au=BLAIN,%20P%20G&rft.date=2001-11-01&rft.volume=58&rft.issue=11&rft.spage=689&rft.epage=690&rft.pages=689-690&rft.issn=1351-0711&rft.eissn=1470-7926&rft_id=info:doi/10.1136/oem.58.11.689&rft_dat=%3Cgale_pubme%3EA80194116%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1781526856&rft_id=info:pmid/11600721&rft_galeid=A80194116&rfr_iscdi=true