Epidemiological response to a suspected excess of cancer among a group of workers exposed to multiple radiological and chemical hazards
OBJECTIVE An excess of cancer was suspected by workers of the metallurgy department at the French Atomic Energy Commissariat (CEA) after several deaths from cancer were reported in 1983 and 1984. After a descriptive study performed by the CEA in 1985 the results of which were not conclusive enough t...
Gespeichert in:
Veröffentlicht in: | Occupational and environmental medicine (London, England) England), 2000-03, Vol.57 (3), p.188-194 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 194 |
---|---|
container_issue | 3 |
container_start_page | 188 |
container_title | Occupational and environmental medicine (London, England) |
container_volume | 57 |
creator | Baysson, H Laurier, D Tirmarche, M Valenty, M Giraud, J M |
description | OBJECTIVE An excess of cancer was suspected by workers of the metallurgy department at the French Atomic Energy Commissariat (CEA) after several deaths from cancer were reported in 1983 and 1984. After a descriptive study performed by the CEA in 1985 the results of which were not conclusive enough to put an end to the controversy, the present cohort study was undertaken in 1989. METHODS As no specific exposure, or a precise cancer site was suspected, it was decided to include all subjects who had worked at the metallurgy department for at least 1 year between 1950 and 1968. The cohort was followed up to 31 December 1990. Individual occupational exposures were determined retrospectively for each year from 1950 to 1990, both qualitatively (annual job, and hazard records, and assistance from former workers) and quantitatively (for external radiation). On the basis of these exposures, three types of occupational tasks were identified: handling of chemicals, radionuclides, and external radiation. Standardised mortality ratios (SMRs) were calculated to estimate the risk of death, and the existence of an association between risk of cancer and each of the three tasks was tested. RESULTS The cohort included 356 workers, followed up for an average of 30 years (total of 10 820 person-years). The number of deaths from all causes and from all cancer sites were respectively 44 and 21. No excess of cancer deaths was found for the study period (SMR 0.77), nor was there a peak in 1983–4. The risk of death from all cancer sites increased with the duration of exposure to chemicals. CONCLUSION The results do not justify the workers' impression of an excess of cancer. They suggest, however, that the duration of work at some tasks that involved handling chemicals may be an indicator of risk of cancer. Communication to the workers during the study played an important part in reducing their concern, contributing to their better understanding of the results. |
doi_str_mv | 10.1136/oem.57.3.188 |
format | Article |
fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1739916</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>27731284</jstor_id><sourcerecordid>27731284</sourcerecordid><originalsourceid>FETCH-LOGICAL-b590t-c1a6b1279a2a806fc1af24ecac2bf1b793ccef3099f281f445b92b111bbedefd3</originalsourceid><addsrcrecordid>eNp9kU2P0zAQhiMEYpeFG1dQJJC4kOKxkzi5IKFqP5CqIqGFAxfLccZtukkcPAks_AH-9rpq1S4ckA_2eB6_M-M3ip4DmwGI_J3DbpbJmZhBUTyITiGVLJElzx-Gs8ggYRLgJHpCtGEMhBT8cXQCrAAW1mn053xoauwa17pVY3Qbe6TB9YTx6GId00QDmhHrGG8NEsXOxkb3Bn2sO9evArLybhq29z-dv0FPgRwchRdBoJvasRlajL2ujyV0X8dmHYpug7X-rX1NT6NHVreEz_b7WfTl4vx6fpUsPl1-nH9YJFVWsjExoPMKuCw11wXLbYgtT9FowysLlSyFMWgFK0vLC7BpmlUlrwCgqrBGW4uz6P1Od5iqDmuD_eh1qwbfdNr_Uk436u9M36zVyv1QIEVZQh4E3uwFvPs-IY2qa8hg2-oe3URKpkLkZQ5pIF_9Q27c5PswXRArIMsgLbZ6b3eU8Y7Ioz30AkxtDVbBYJVJJVQwOOAv7_d_D945GoDXe0BT-F_rg1sNHTku0zTPAvZih21odP6Q5lIK4MW2-WSXb2jE20Ne-xuVSyEztfw6VxfLb4vr4vOlWh6_peo2_5_gDnr918E</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781551486</pqid></control><display><type>article</type><title>Epidemiological response to a suspected excess of cancer among a group of workers exposed to multiple radiological and chemical hazards</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>JSTOR Archive Collection A-Z Listing</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Baysson, H ; Laurier, D ; Tirmarche, M ; Valenty, M ; Giraud, J M</creator><creatorcontrib>Baysson, H ; Laurier, D ; Tirmarche, M ; Valenty, M ; Giraud, J M</creatorcontrib><description>OBJECTIVE An excess of cancer was suspected by workers of the metallurgy department at the French Atomic Energy Commissariat (CEA) after several deaths from cancer were reported in 1983 and 1984. After a descriptive study performed by the CEA in 1985 the results of which were not conclusive enough to put an end to the controversy, the present cohort study was undertaken in 1989. METHODS As no specific exposure, or a precise cancer site was suspected, it was decided to include all subjects who had worked at the metallurgy department for at least 1 year between 1950 and 1968. The cohort was followed up to 31 December 1990. Individual occupational exposures were determined retrospectively for each year from 1950 to 1990, both qualitatively (annual job, and hazard records, and assistance from former workers) and quantitatively (for external radiation). On the basis of these exposures, three types of occupational tasks were identified: handling of chemicals, radionuclides, and external radiation. Standardised mortality ratios (SMRs) were calculated to estimate the risk of death, and the existence of an association between risk of cancer and each of the three tasks was tested. RESULTS The cohort included 356 workers, followed up for an average of 30 years (total of 10 820 person-years). The number of deaths from all causes and from all cancer sites were respectively 44 and 21. No excess of cancer deaths was found for the study period (SMR 0.77), nor was there a peak in 1983–4. The risk of death from all cancer sites increased with the duration of exposure to chemicals. CONCLUSION The results do not justify the workers' impression of an excess of cancer. They suggest, however, that the duration of work at some tasks that involved handling chemicals may be an indicator of risk of cancer. Communication to the workers during the study played an important part in reducing their concern, contributing to their better understanding of the results.</description><identifier>ISSN: 1351-0711</identifier><identifier>EISSN: 1470-7926</identifier><identifier>DOI: 10.1136/oem.57.3.188</identifier><identifier>PMID: 10810101</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Cancer ; Careers ; Chemical compounds (mineral, organic) ; Chemical hazards ; Chemical, physic and infectious diseases ; Chemicals ; cluster ; Cluster Analysis ; Cohort Studies ; Death ; Dosimetry ; Epidemiology ; Female ; Follow-Up Studies ; France - epidemiology ; Health risks ; Humans ; Hypotheses ; Ionizing radiation ; Male ; Medical sciences ; Metallurgy ; Metallurgy - statistics & numerical data ; Middle Aged ; Mortality ; Multiple Myeloma - epidemiology ; Multiple Myeloma - etiology ; Multiple Myeloma - mortality ; Neoplasms - epidemiology ; Neoplasms - etiology ; Neoplasms - mortality ; Neoplasms, Radiation-Induced - epidemiology ; Neoplasms, Radiation-Induced - etiology ; Neoplasms, Radiation-Induced - mortality ; Nuclear Energy ; Occupational Diseases - epidemiology ; Occupational Diseases - etiology ; Occupational exposure ; Occupational Exposure - adverse effects ; Occupational Exposure - classification ; occupational exposures ; Occupational medicine ; Public health. Hygiene-occupational medicine ; Radiation ; Radiation dosage ; Radioisotopes - adverse effects ; Radionuclides ; Tumors ; Workers</subject><ispartof>Occupational and environmental medicine (London, England), 2000-03, Vol.57 (3), p.188-194</ispartof><rights>Occupational and Environmental Medicine</rights><rights>2000 INIST-CNRS</rights><rights>Copyright: 2000 Occupational and Environmental Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b590t-c1a6b1279a2a806fc1af24ecac2bf1b793ccef3099f281f445b92b111bbedefd3</citedby><cites>FETCH-LOGICAL-b590t-c1a6b1279a2a806fc1af24ecac2bf1b793ccef3099f281f445b92b111bbedefd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/27731284$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/27731284$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,728,781,785,804,886,27928,27929,53795,53797,58021,58254</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1274465$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10810101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baysson, H</creatorcontrib><creatorcontrib>Laurier, D</creatorcontrib><creatorcontrib>Tirmarche, M</creatorcontrib><creatorcontrib>Valenty, M</creatorcontrib><creatorcontrib>Giraud, J M</creatorcontrib><title>Epidemiological response to a suspected excess of cancer among a group of workers exposed to multiple radiological and chemical hazards</title><title>Occupational and environmental medicine (London, England)</title><addtitle>Occup Environ Med</addtitle><description>OBJECTIVE An excess of cancer was suspected by workers of the metallurgy department at the French Atomic Energy Commissariat (CEA) after several deaths from cancer were reported in 1983 and 1984. After a descriptive study performed by the CEA in 1985 the results of which were not conclusive enough to put an end to the controversy, the present cohort study was undertaken in 1989. METHODS As no specific exposure, or a precise cancer site was suspected, it was decided to include all subjects who had worked at the metallurgy department for at least 1 year between 1950 and 1968. The cohort was followed up to 31 December 1990. Individual occupational exposures were determined retrospectively for each year from 1950 to 1990, both qualitatively (annual job, and hazard records, and assistance from former workers) and quantitatively (for external radiation). On the basis of these exposures, three types of occupational tasks were identified: handling of chemicals, radionuclides, and external radiation. Standardised mortality ratios (SMRs) were calculated to estimate the risk of death, and the existence of an association between risk of cancer and each of the three tasks was tested. RESULTS The cohort included 356 workers, followed up for an average of 30 years (total of 10 820 person-years). The number of deaths from all causes and from all cancer sites were respectively 44 and 21. No excess of cancer deaths was found for the study period (SMR 0.77), nor was there a peak in 1983–4. The risk of death from all cancer sites increased with the duration of exposure to chemicals. CONCLUSION The results do not justify the workers' impression of an excess of cancer. They suggest, however, that the duration of work at some tasks that involved handling chemicals may be an indicator of risk of cancer. Communication to the workers during the study played an important part in reducing their concern, contributing to their better understanding of the results.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Careers</subject><subject>Chemical compounds (mineral, organic)</subject><subject>Chemical hazards</subject><subject>Chemical, physic and infectious diseases</subject><subject>Chemicals</subject><subject>cluster</subject><subject>Cluster Analysis</subject><subject>Cohort Studies</subject><subject>Death</subject><subject>Dosimetry</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>France - epidemiology</subject><subject>Health risks</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Ionizing radiation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metallurgy</subject><subject>Metallurgy - statistics & numerical data</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multiple Myeloma - epidemiology</subject><subject>Multiple Myeloma - etiology</subject><subject>Multiple Myeloma - mortality</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - etiology</subject><subject>Neoplasms - mortality</subject><subject>Neoplasms, Radiation-Induced - epidemiology</subject><subject>Neoplasms, Radiation-Induced - etiology</subject><subject>Neoplasms, Radiation-Induced - mortality</subject><subject>Nuclear Energy</subject><subject>Occupational Diseases - epidemiology</subject><subject>Occupational Diseases - etiology</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational Exposure - classification</subject><subject>occupational exposures</subject><subject>Occupational medicine</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Radiation</subject><subject>Radiation dosage</subject><subject>Radioisotopes - adverse effects</subject><subject>Radionuclides</subject><subject>Tumors</subject><subject>Workers</subject><issn>1351-0711</issn><issn>1470-7926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU2P0zAQhiMEYpeFG1dQJJC4kOKxkzi5IKFqP5CqIqGFAxfLccZtukkcPAks_AH-9rpq1S4ckA_2eB6_M-M3ip4DmwGI_J3DbpbJmZhBUTyITiGVLJElzx-Gs8ggYRLgJHpCtGEMhBT8cXQCrAAW1mn053xoauwa17pVY3Qbe6TB9YTx6GId00QDmhHrGG8NEsXOxkb3Bn2sO9evArLybhq29z-dv0FPgRwchRdBoJvasRlajL2ujyV0X8dmHYpug7X-rX1NT6NHVreEz_b7WfTl4vx6fpUsPl1-nH9YJFVWsjExoPMKuCw11wXLbYgtT9FowysLlSyFMWgFK0vLC7BpmlUlrwCgqrBGW4uz6P1Od5iqDmuD_eh1qwbfdNr_Uk436u9M36zVyv1QIEVZQh4E3uwFvPs-IY2qa8hg2-oe3URKpkLkZQ5pIF_9Q27c5PswXRArIMsgLbZ6b3eU8Y7Ioz30AkxtDVbBYJVJJVQwOOAv7_d_D945GoDXe0BT-F_rg1sNHTku0zTPAvZih21odP6Q5lIK4MW2-WSXb2jE20Ne-xuVSyEztfw6VxfLb4vr4vOlWh6_peo2_5_gDnr918E</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>Baysson, H</creator><creator>Laurier, D</creator><creator>Tirmarche, M</creator><creator>Valenty, M</creator><creator>Giraud, J M</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7QQ</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>KR7</scope><scope>5PM</scope></search><sort><creationdate>20000301</creationdate><title>Epidemiological response to a suspected excess of cancer among a group of workers exposed to multiple radiological and chemical hazards</title><author>Baysson, H ; Laurier, D ; Tirmarche, M ; Valenty, M ; Giraud, J M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b590t-c1a6b1279a2a806fc1af24ecac2bf1b793ccef3099f281f445b92b111bbedefd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Careers</topic><topic>Chemical compounds (mineral, organic)</topic><topic>Chemical hazards</topic><topic>Chemical, physic and infectious diseases</topic><topic>Chemicals</topic><topic>cluster</topic><topic>Cluster Analysis</topic><topic>Cohort Studies</topic><topic>Death</topic><topic>Dosimetry</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>France - epidemiology</topic><topic>Health risks</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Ionizing radiation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metallurgy</topic><topic>Metallurgy - statistics & numerical data</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multiple Myeloma - epidemiology</topic><topic>Multiple Myeloma - etiology</topic><topic>Multiple Myeloma - mortality</topic><topic>Neoplasms - epidemiology</topic><topic>Neoplasms - etiology</topic><topic>Neoplasms - mortality</topic><topic>Neoplasms, Radiation-Induced - epidemiology</topic><topic>Neoplasms, Radiation-Induced - etiology</topic><topic>Neoplasms, Radiation-Induced - mortality</topic><topic>Nuclear Energy</topic><topic>Occupational Diseases - epidemiology</topic><topic>Occupational Diseases - etiology</topic><topic>Occupational exposure</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational Exposure - classification</topic><topic>occupational exposures</topic><topic>Occupational medicine</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Radiation</topic><topic>Radiation dosage</topic><topic>Radioisotopes - adverse effects</topic><topic>Radionuclides</topic><topic>Tumors</topic><topic>Workers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baysson, H</creatorcontrib><creatorcontrib>Laurier, D</creatorcontrib><creatorcontrib>Tirmarche, M</creatorcontrib><creatorcontrib>Valenty, M</creatorcontrib><creatorcontrib>Giraud, J M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Engineering Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Ceramic Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Occupational and environmental medicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baysson, H</au><au>Laurier, D</au><au>Tirmarche, M</au><au>Valenty, M</au><au>Giraud, J M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiological response to a suspected excess of cancer among a group of workers exposed to multiple radiological and chemical hazards</atitle><jtitle>Occupational and environmental medicine (London, England)</jtitle><addtitle>Occup Environ Med</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>57</volume><issue>3</issue><spage>188</spage><epage>194</epage><pages>188-194</pages><issn>1351-0711</issn><eissn>1470-7926</eissn><abstract>OBJECTIVE An excess of cancer was suspected by workers of the metallurgy department at the French Atomic Energy Commissariat (CEA) after several deaths from cancer were reported in 1983 and 1984. After a descriptive study performed by the CEA in 1985 the results of which were not conclusive enough to put an end to the controversy, the present cohort study was undertaken in 1989. METHODS As no specific exposure, or a precise cancer site was suspected, it was decided to include all subjects who had worked at the metallurgy department for at least 1 year between 1950 and 1968. The cohort was followed up to 31 December 1990. Individual occupational exposures were determined retrospectively for each year from 1950 to 1990, both qualitatively (annual job, and hazard records, and assistance from former workers) and quantitatively (for external radiation). On the basis of these exposures, three types of occupational tasks were identified: handling of chemicals, radionuclides, and external radiation. Standardised mortality ratios (SMRs) were calculated to estimate the risk of death, and the existence of an association between risk of cancer and each of the three tasks was tested. RESULTS The cohort included 356 workers, followed up for an average of 30 years (total of 10 820 person-years). The number of deaths from all causes and from all cancer sites were respectively 44 and 21. No excess of cancer deaths was found for the study period (SMR 0.77), nor was there a peak in 1983–4. The risk of death from all cancer sites increased with the duration of exposure to chemicals. CONCLUSION The results do not justify the workers' impression of an excess of cancer. They suggest, however, that the duration of work at some tasks that involved handling chemicals may be an indicator of risk of cancer. Communication to the workers during the study played an important part in reducing their concern, contributing to their better understanding of the results.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>10810101</pmid><doi>10.1136/oem.57.3.188</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1351-0711 |
ispartof | Occupational and environmental medicine (London, England), 2000-03, Vol.57 (3), p.188-194 |
issn | 1351-0711 1470-7926 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1739916 |
source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection |
subjects | Adolescent Adult Aged Biological and medical sciences Cancer Careers Chemical compounds (mineral, organic) Chemical hazards Chemical, physic and infectious diseases Chemicals cluster Cluster Analysis Cohort Studies Death Dosimetry Epidemiology Female Follow-Up Studies France - epidemiology Health risks Humans Hypotheses Ionizing radiation Male Medical sciences Metallurgy Metallurgy - statistics & numerical data Middle Aged Mortality Multiple Myeloma - epidemiology Multiple Myeloma - etiology Multiple Myeloma - mortality Neoplasms - epidemiology Neoplasms - etiology Neoplasms - mortality Neoplasms, Radiation-Induced - epidemiology Neoplasms, Radiation-Induced - etiology Neoplasms, Radiation-Induced - mortality Nuclear Energy Occupational Diseases - epidemiology Occupational Diseases - etiology Occupational exposure Occupational Exposure - adverse effects Occupational Exposure - classification occupational exposures Occupational medicine Public health. Hygiene-occupational medicine Radiation Radiation dosage Radioisotopes - adverse effects Radionuclides Tumors Workers |
title | Epidemiological response to a suspected excess of cancer among a group of workers exposed to multiple radiological and chemical hazards |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T22%3A52%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Epidemiological%20response%20to%20a%20suspected%20excess%20of%20cancer%20among%20a%20group%20of%20workers%20exposed%20to%20multiple%20radiological%20and%20chemical%20hazards&rft.jtitle=Occupational%20and%20environmental%20medicine%20(London,%20England)&rft.au=Baysson,%20H&rft.date=2000-03-01&rft.volume=57&rft.issue=3&rft.spage=188&rft.epage=194&rft.pages=188-194&rft.issn=1351-0711&rft.eissn=1470-7926&rft_id=info:doi/10.1136/oem.57.3.188&rft_dat=%3Cjstor_pubme%3E27731284%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1781551486&rft_id=info:pmid/10810101&rft_jstor_id=27731284&rfr_iscdi=true |