Population based study of late onset cerebellar ataxia in south east Wales
Objective: To determine the prevalence and causation of late onset cerebellar ataxia (LOCA) in south east Wales, United Kingdom. Methods: A population based study of LOCA was conducted in a defined geographical region with a total population of 742 400. Multiple sources of ascertainment were used to...
Gespeichert in:
Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2004-08, Vol.75 (8), p.1129-1134 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1134 |
---|---|
container_issue | 8 |
container_start_page | 1129 |
container_title | Journal of neurology, neurosurgery and psychiatry |
container_volume | 75 |
creator | Muzaimi, M B Thomas, J Palmer-Smith, S Rosser, L Harper, P S Wiles, C M Ravine, D Robertson, N P |
description | Objective: To determine the prevalence and causation of late onset cerebellar ataxia (LOCA) in south east Wales, United Kingdom. Methods: A population based study of LOCA was conducted in a defined geographical region with a total population of 742 400. Multiple sources of ascertainment were used to identify all cases prevalent on 1 January 2001. The inclusion criteria were: a predominantly progressive cerebellar ataxia with onset of symptoms at age ⩾18 years; and disease duration of ⩾1 year. Cases with known acquired ataxias, ataxic syndromes with associated prominent autonomic dysfunction and/or atypical parkinsonism suggestive of multiple system atrophy and disorders with ataxia as a minor feature were excluded. Results: We identified 76 index cases of LOCA, of whom 63 were sporadic, idiopathic LOCA (ILOCA) and 13 were familial LOCA, of whom six had either spinocerebellar ataxia type 6, Friedreich’s ataxia or dominant episodic ataxia. The mean annual incidence rate for the period 1999–2001 was 0.3/100 000 population/year. The crude prevalence rates were 8.4 per 100 000 (95% CI 7.2 to 11.6) for ILOCA and 1.8 per 100 000 (95% CI 0.8 to 2.7) for inherited LOCA. Of the 54/63 (85.7%) patients with ILOCA who were assessed, mean (SD) age at onset of symptoms was 53.8 (14.1) years (range 19 to 78) with a male:female ratio of 2.1:1. The mean disease duration was 8.7 (6.3) years (range 1 to 31). The most frequent presenting complaint was disturbance in gait (90.7%). One-third had a relatively pure cerebellar syndrome (33.3%) and two-thirds (66.7%) had additional extracerebellar neurological features. The majority (92%) were ambulant but only 9.3% were independently self-caring. Conclusion: This population based study provides insight into LOCA within a defined region and will inform decisions about the rational use of healthcare resources for patients with LOCA. |
doi_str_mv | 10.1136/jnnp.2003.014662 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1739172</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4023791231</sourcerecordid><originalsourceid>FETCH-LOGICAL-b590t-9f165262f208ab06ed12deac92af9ec6fb0b27b9ff5790d91ecfafb8cb4665ca3</originalsourceid><addsrcrecordid>eNqFkc9rFDEUx4Modlu9e5KA1IvMmmQ2mclFkMWflOpBa_ESXjKJnXU22SaZ0v73ZpilrV7M5UHe5335fvki9IySJaW1eL3xfrdkhNRLQldCsAdoUWZb1TU5f4gWhDBW1YSTA3SY0oZMr5WP0QHljLeMrhbo89ewGwfIffBYQ7IdTnnsbnBwuPxaHHyyGRsbrbbDABFDhusecO9xCmO-wBZSxj9gsOkJeuRgSPbpfh6h7-_ffVt_rE6-fPi0fntSaS5JrqSjgjPBHCMtaCJsR1lnwUgGTlojnCaaNVo6xxtJOkmtceB0a3RJyA3UR-jNrLsb9dZ2xvocYVC72G8h3qgAvfp74_sL9StcKdrUkjasCLzcC8RwOdqU1bZPZornbRiTEqKhsl61BXzxD7gJY_QlXNFqKasbzkWhyEyZGFKK1t1aoURNNampJjXVpOaaysnz-xHuDva9FOB4D0AyMLgI3vTpHielYC0vXDVzfcr2-nYP8bcSTbGnTs_W6pzwM_5TctUU_tXM6-3m_zb_ADoNuX8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781237556</pqid></control><display><type>article</type><title>Population based study of late onset cerebellar ataxia in south east Wales</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Muzaimi, M B ; Thomas, J ; Palmer-Smith, S ; Rosser, L ; Harper, P S ; Wiles, C M ; Ravine, D ; Robertson, N P</creator><creatorcontrib>Muzaimi, M B ; Thomas, J ; Palmer-Smith, S ; Rosser, L ; Harper, P S ; Wiles, C M ; Ravine, D ; Robertson, N P</creatorcontrib><description>Objective: To determine the prevalence and causation of late onset cerebellar ataxia (LOCA) in south east Wales, United Kingdom. Methods: A population based study of LOCA was conducted in a defined geographical region with a total population of 742 400. Multiple sources of ascertainment were used to identify all cases prevalent on 1 January 2001. The inclusion criteria were: a predominantly progressive cerebellar ataxia with onset of symptoms at age ⩾18 years; and disease duration of ⩾1 year. Cases with known acquired ataxias, ataxic syndromes with associated prominent autonomic dysfunction and/or atypical parkinsonism suggestive of multiple system atrophy and disorders with ataxia as a minor feature were excluded. Results: We identified 76 index cases of LOCA, of whom 63 were sporadic, idiopathic LOCA (ILOCA) and 13 were familial LOCA, of whom six had either spinocerebellar ataxia type 6, Friedreich’s ataxia or dominant episodic ataxia. The mean annual incidence rate for the period 1999–2001 was 0.3/100 000 population/year. The crude prevalence rates were 8.4 per 100 000 (95% CI 7.2 to 11.6) for ILOCA and 1.8 per 100 000 (95% CI 0.8 to 2.7) for inherited LOCA. Of the 54/63 (85.7%) patients with ILOCA who were assessed, mean (SD) age at onset of symptoms was 53.8 (14.1) years (range 19 to 78) with a male:female ratio of 2.1:1. The mean disease duration was 8.7 (6.3) years (range 1 to 31). The most frequent presenting complaint was disturbance in gait (90.7%). One-third had a relatively pure cerebellar syndrome (33.3%) and two-thirds (66.7%) had additional extracerebellar neurological features. The majority (92%) were ambulant but only 9.3% were independently self-caring. Conclusion: This population based study provides insight into LOCA within a defined region and will inform decisions about the rational use of healthcare resources for patients with LOCA.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.2003.014662</identifier><identifier>PMID: 15258214</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>activities of daily living ; ADL ; Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Ataxia ; Biological and medical sciences ; Bro Taf Health Authority ; BTHA ; Cerebellar Ataxia - epidemiology ; Cerebellar Ataxia - genetics ; Cerebellar Ataxia - pathology ; Classification ; Disease ; Epidemiologic Studies ; Family medical history ; Female ; FRDA ; Friedreich’s ataxia ; general practitioner ; Genetics ; Geography ; Hospitals ; Humans ; late onset cerebellar ataxia ; LOCA ; Male ; Medical sciences ; Middle Aged ; MSA ; multiple system atrophy ; Needs Assessment ; Neurology ; Phenotype ; Population ; population based ; Prevalence ; Registries - statistics & numerical data ; SCA ; spinocerebellar ataxia ; Wales - epidemiology</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 2004-08, Vol.75 (8), p.1129-1134</ispartof><rights>Copyright 2004 Journal of Neurology Neurosurgery and Psychiatry</rights><rights>2004 INIST-CNRS</rights><rights>Copyright: 2004 Copyright 2004 Journal of Neurology Neurosurgery and Psychiatry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b590t-9f165262f208ab06ed12deac92af9ec6fb0b27b9ff5790d91ecfafb8cb4665ca3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1739172/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1739172/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15996285$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15258214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muzaimi, M B</creatorcontrib><creatorcontrib>Thomas, J</creatorcontrib><creatorcontrib>Palmer-Smith, S</creatorcontrib><creatorcontrib>Rosser, L</creatorcontrib><creatorcontrib>Harper, P S</creatorcontrib><creatorcontrib>Wiles, C M</creatorcontrib><creatorcontrib>Ravine, D</creatorcontrib><creatorcontrib>Robertson, N P</creatorcontrib><title>Population based study of late onset cerebellar ataxia in south east Wales</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>Objective: To determine the prevalence and causation of late onset cerebellar ataxia (LOCA) in south east Wales, United Kingdom. Methods: A population based study of LOCA was conducted in a defined geographical region with a total population of 742 400. Multiple sources of ascertainment were used to identify all cases prevalent on 1 January 2001. The inclusion criteria were: a predominantly progressive cerebellar ataxia with onset of symptoms at age ⩾18 years; and disease duration of ⩾1 year. Cases with known acquired ataxias, ataxic syndromes with associated prominent autonomic dysfunction and/or atypical parkinsonism suggestive of multiple system atrophy and disorders with ataxia as a minor feature were excluded. Results: We identified 76 index cases of LOCA, of whom 63 were sporadic, idiopathic LOCA (ILOCA) and 13 were familial LOCA, of whom six had either spinocerebellar ataxia type 6, Friedreich’s ataxia or dominant episodic ataxia. The mean annual incidence rate for the period 1999–2001 was 0.3/100 000 population/year. The crude prevalence rates were 8.4 per 100 000 (95% CI 7.2 to 11.6) for ILOCA and 1.8 per 100 000 (95% CI 0.8 to 2.7) for inherited LOCA. Of the 54/63 (85.7%) patients with ILOCA who were assessed, mean (SD) age at onset of symptoms was 53.8 (14.1) years (range 19 to 78) with a male:female ratio of 2.1:1. The mean disease duration was 8.7 (6.3) years (range 1 to 31). The most frequent presenting complaint was disturbance in gait (90.7%). One-third had a relatively pure cerebellar syndrome (33.3%) and two-thirds (66.7%) had additional extracerebellar neurological features. The majority (92%) were ambulant but only 9.3% were independently self-caring. Conclusion: This population based study provides insight into LOCA within a defined region and will inform decisions about the rational use of healthcare resources for patients with LOCA.</description><subject>activities of daily living</subject><subject>ADL</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Ataxia</subject><subject>Biological and medical sciences</subject><subject>Bro Taf Health Authority</subject><subject>BTHA</subject><subject>Cerebellar Ataxia - epidemiology</subject><subject>Cerebellar Ataxia - genetics</subject><subject>Cerebellar Ataxia - pathology</subject><subject>Classification</subject><subject>Disease</subject><subject>Epidemiologic Studies</subject><subject>Family medical history</subject><subject>Female</subject><subject>FRDA</subject><subject>Friedreich’s ataxia</subject><subject>general practitioner</subject><subject>Genetics</subject><subject>Geography</subject><subject>Hospitals</subject><subject>Humans</subject><subject>late onset cerebellar ataxia</subject><subject>LOCA</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MSA</subject><subject>multiple system atrophy</subject><subject>Needs Assessment</subject><subject>Neurology</subject><subject>Phenotype</subject><subject>Population</subject><subject>population based</subject><subject>Prevalence</subject><subject>Registries - statistics & numerical data</subject><subject>SCA</subject><subject>spinocerebellar ataxia</subject><subject>Wales - epidemiology</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc9rFDEUx4Modlu9e5KA1IvMmmQ2mclFkMWflOpBa_ESXjKJnXU22SaZ0v73ZpilrV7M5UHe5335fvki9IySJaW1eL3xfrdkhNRLQldCsAdoUWZb1TU5f4gWhDBW1YSTA3SY0oZMr5WP0QHljLeMrhbo89ewGwfIffBYQ7IdTnnsbnBwuPxaHHyyGRsbrbbDABFDhusecO9xCmO-wBZSxj9gsOkJeuRgSPbpfh6h7-_ffVt_rE6-fPi0fntSaS5JrqSjgjPBHCMtaCJsR1lnwUgGTlojnCaaNVo6xxtJOkmtceB0a3RJyA3UR-jNrLsb9dZ2xvocYVC72G8h3qgAvfp74_sL9StcKdrUkjasCLzcC8RwOdqU1bZPZornbRiTEqKhsl61BXzxD7gJY_QlXNFqKasbzkWhyEyZGFKK1t1aoURNNampJjXVpOaaysnz-xHuDva9FOB4D0AyMLgI3vTpHielYC0vXDVzfcr2-nYP8bcSTbGnTs_W6pzwM_5TctUU_tXM6-3m_zb_ADoNuX8</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Muzaimi, M B</creator><creator>Thomas, J</creator><creator>Palmer-Smith, S</creator><creator>Rosser, L</creator><creator>Harper, P S</creator><creator>Wiles, C M</creator><creator>Ravine, D</creator><creator>Robertson, N P</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20040801</creationdate><title>Population based study of late onset cerebellar ataxia in south east Wales</title><author>Muzaimi, M B ; Thomas, J ; Palmer-Smith, S ; Rosser, L ; Harper, P S ; Wiles, C M ; Ravine, D ; Robertson, N P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b590t-9f165262f208ab06ed12deac92af9ec6fb0b27b9ff5790d91ecfafb8cb4665ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>activities of daily living</topic><topic>ADL</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Ataxia</topic><topic>Biological and medical sciences</topic><topic>Bro Taf Health Authority</topic><topic>BTHA</topic><topic>Cerebellar Ataxia - epidemiology</topic><topic>Cerebellar Ataxia - genetics</topic><topic>Cerebellar Ataxia - pathology</topic><topic>Classification</topic><topic>Disease</topic><topic>Epidemiologic Studies</topic><topic>Family medical history</topic><topic>Female</topic><topic>FRDA</topic><topic>Friedreich’s ataxia</topic><topic>general practitioner</topic><topic>Genetics</topic><topic>Geography</topic><topic>Hospitals</topic><topic>Humans</topic><topic>late onset cerebellar ataxia</topic><topic>LOCA</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MSA</topic><topic>multiple system atrophy</topic><topic>Needs Assessment</topic><topic>Neurology</topic><topic>Phenotype</topic><topic>Population</topic><topic>population based</topic><topic>Prevalence</topic><topic>Registries - statistics & numerical data</topic><topic>SCA</topic><topic>spinocerebellar ataxia</topic><topic>Wales - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muzaimi, M B</creatorcontrib><creatorcontrib>Thomas, J</creatorcontrib><creatorcontrib>Palmer-Smith, S</creatorcontrib><creatorcontrib>Rosser, L</creatorcontrib><creatorcontrib>Harper, P S</creatorcontrib><creatorcontrib>Wiles, C M</creatorcontrib><creatorcontrib>Ravine, D</creatorcontrib><creatorcontrib>Robertson, N P</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muzaimi, M B</au><au>Thomas, J</au><au>Palmer-Smith, S</au><au>Rosser, L</au><au>Harper, P S</au><au>Wiles, C M</au><au>Ravine, D</au><au>Robertson, N P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Population based study of late onset cerebellar ataxia in south east Wales</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>2004-08-01</date><risdate>2004</risdate><volume>75</volume><issue>8</issue><spage>1129</spage><epage>1134</epage><pages>1129-1134</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>Objective: To determine the prevalence and causation of late onset cerebellar ataxia (LOCA) in south east Wales, United Kingdom. Methods: A population based study of LOCA was conducted in a defined geographical region with a total population of 742 400. Multiple sources of ascertainment were used to identify all cases prevalent on 1 January 2001. The inclusion criteria were: a predominantly progressive cerebellar ataxia with onset of symptoms at age ⩾18 years; and disease duration of ⩾1 year. Cases with known acquired ataxias, ataxic syndromes with associated prominent autonomic dysfunction and/or atypical parkinsonism suggestive of multiple system atrophy and disorders with ataxia as a minor feature were excluded. Results: We identified 76 index cases of LOCA, of whom 63 were sporadic, idiopathic LOCA (ILOCA) and 13 were familial LOCA, of whom six had either spinocerebellar ataxia type 6, Friedreich’s ataxia or dominant episodic ataxia. The mean annual incidence rate for the period 1999–2001 was 0.3/100 000 population/year. The crude prevalence rates were 8.4 per 100 000 (95% CI 7.2 to 11.6) for ILOCA and 1.8 per 100 000 (95% CI 0.8 to 2.7) for inherited LOCA. Of the 54/63 (85.7%) patients with ILOCA who were assessed, mean (SD) age at onset of symptoms was 53.8 (14.1) years (range 19 to 78) with a male:female ratio of 2.1:1. The mean disease duration was 8.7 (6.3) years (range 1 to 31). The most frequent presenting complaint was disturbance in gait (90.7%). One-third had a relatively pure cerebellar syndrome (33.3%) and two-thirds (66.7%) had additional extracerebellar neurological features. The majority (92%) were ambulant but only 9.3% were independently self-caring. Conclusion: This population based study provides insight into LOCA within a defined region and will inform decisions about the rational use of healthcare resources for patients with LOCA.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>15258214</pmid><doi>10.1136/jnnp.2003.014662</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0022-3050 |
ispartof | Journal of neurology, neurosurgery and psychiatry, 2004-08, Vol.75 (8), p.1129-1134 |
issn | 0022-3050 1468-330X |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1739172 |
source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
subjects | activities of daily living ADL Adult Age of Onset Aged Aged, 80 and over Ataxia Biological and medical sciences Bro Taf Health Authority BTHA Cerebellar Ataxia - epidemiology Cerebellar Ataxia - genetics Cerebellar Ataxia - pathology Classification Disease Epidemiologic Studies Family medical history Female FRDA Friedreich’s ataxia general practitioner Genetics Geography Hospitals Humans late onset cerebellar ataxia LOCA Male Medical sciences Middle Aged MSA multiple system atrophy Needs Assessment Neurology Phenotype Population population based Prevalence Registries - statistics & numerical data SCA spinocerebellar ataxia Wales - epidemiology |
title | Population based study of late onset cerebellar ataxia in south east Wales |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T05%3A55%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Population%20based%20study%20of%20late%20onset%20cerebellar%20ataxia%20in%20south%20east%20Wales&rft.jtitle=Journal%20of%20neurology,%20neurosurgery%20and%20psychiatry&rft.au=Muzaimi,%20M%20B&rft.date=2004-08-01&rft.volume=75&rft.issue=8&rft.spage=1129&rft.epage=1134&rft.pages=1129-1134&rft.issn=0022-3050&rft.eissn=1468-330X&rft.coden=JNNPAU&rft_id=info:doi/10.1136/jnnp.2003.014662&rft_dat=%3Cproquest_pubme%3E4023791231%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1781237556&rft_id=info:pmid/15258214&rfr_iscdi=true |