Altered cerebellar functional connectivity mediates potential adaptive plasticity in patients with multiple sclerosis
Background: The cerebellum is of potential interest for understanding adaptive responses in motor control in patients with multiple sclerosis because of the high intrinsic synaptic plasticity of this brain region. Objective: To assess the relative roles of interactions between the neocortex and the...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2004-06, Vol.75 (6), p.840-846 |
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| creator | Saini, S DeStefano, N Smith, S Guidi, L Amato, M P Federico, A Matthews, P M |
| description | Background: The cerebellum is of potential interest for understanding adaptive responses in motor control in patients with multiple sclerosis because of the high intrinsic synaptic plasticity of this brain region. Objective: To assess the relative roles of interactions between the neocortex and the cerebellum using measures of functional connectivity. Methods: A role for altered neocortical–cerebellar functional connectivity in adaptive responses to injury from multiple sclerosis was tested using 1.5 T functional magnetic resonance imaging (fMRI) during figure writing with the dominant right hand in patients with predominantly early relapsing-remitting multiple sclerosis. Results: Patients (n = 14) showed a more bihemispheric pattern of activation in motor cortex than healthy controls (n = 11). Correlations between task related signal changes in neocortical and cerebellar regions of interest were used as a measure of functional connectivity. Healthy controls showed strong functional connectivity between the left motor cortex and the right cerebellar dentate nucleus. Significant connectivity between the left primary motor cortex and the right dentate was not found in patients. However, patients had significant connectivity between the left premotor neocortex and the ipsilateral (left) cerebellar cortex (crus I), which was not found in healthy controls. Conclusions: Changes in apparent cerebellar–neocortical functional connectivity may mediate potentially adaptive changes in brain motor control in patients with multiple sclerosis. Similar changes in the cerebellum and premotor cortex have been reported in the healthy brain during motor learning, suggesting that common mechanisms may contribute to normal motor learning and motor recovery after injury from multiple sclerosis. |
| doi_str_mv | 10.1136/jnnp.2003.016782 |
| format | Article |
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Objective: To assess the relative roles of interactions between the neocortex and the cerebellum using measures of functional connectivity. Methods: A role for altered neocortical–cerebellar functional connectivity in adaptive responses to injury from multiple sclerosis was tested using 1.5 T functional magnetic resonance imaging (fMRI) during figure writing with the dominant right hand in patients with predominantly early relapsing-remitting multiple sclerosis. Results: Patients (n = 14) showed a more bihemispheric pattern of activation in motor cortex than healthy controls (n = 11). Correlations between task related signal changes in neocortical and cerebellar regions of interest were used as a measure of functional connectivity. Healthy controls showed strong functional connectivity between the left motor cortex and the right cerebellar dentate nucleus. Significant connectivity between the left primary motor cortex and the right dentate was not found in patients. However, patients had significant connectivity between the left premotor neocortex and the ipsilateral (left) cerebellar cortex (crus I), which was not found in healthy controls. Conclusions: Changes in apparent cerebellar–neocortical functional connectivity may mediate potentially adaptive changes in brain motor control in patients with multiple sclerosis. Similar changes in the cerebellum and premotor cortex have been reported in the healthy brain during motor learning, suggesting that common mechanisms may contribute to normal motor learning and motor recovery after injury from multiple sclerosis.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.2003.016782</identifier><identifier>PMID: 15145996</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; brain repair ; Cerebellar Cortex - pathology ; Cerebellar Cortex - physiology ; cerebellum ; Cerebellum - pathology ; Cerebellum - physiology ; Disease Progression ; EDSS ; expanded disability status score ; Female ; FLAME ; FMRIB ; FMRIB’s improved linear model ; FMRIB’s local analysis of mixed effects ; Functional Laterality - physiology ; Hand - physiology ; Humans ; lateralisation index ; Magnetic Resonance Imaging - statistics & numerical data ; Male ; MCFLIRT ; Medical sciences ; Middle Aged ; motion correction using FMIRB’s linear image registration tool ; Motor Cortex - pathology ; Motor Cortex - physiology ; Movement - physiology ; Multiple sclerosis ; Multiple Sclerosis - diagnosis ; Multiple Sclerosis - pathology ; Neocortex - pathology ; Neocortex - physiology ; Neural Pathways - pathology ; Neural Pathways - physiology ; Neurology ; Neuronal Plasticity - physiology ; neurorehabilitation ; Oxford Centre for Functional Magnetic Resonance Imaging of the Brain ; Patients ; Psychomotor Performance - physiology ; region of interest ; ROI ; Scanners</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 2004-06, Vol.75 (6), p.840-846</ispartof><rights>Copyright 2004 Journal of Neurology Neurosurgery and Psychiatry</rights><rights>2004 INIST-CNRS</rights><rights>Copyright: 2004 Copyright 2004 Journal of Neurology Neurosurgery and Psychiatry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b524t-2b66cedaaf0c9c82522d631051550216437831af7fc44af4e7733cb6438802ca3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1739042/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1739042/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15841567$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15145996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saini, S</creatorcontrib><creatorcontrib>DeStefano, N</creatorcontrib><creatorcontrib>Smith, S</creatorcontrib><creatorcontrib>Guidi, L</creatorcontrib><creatorcontrib>Amato, M P</creatorcontrib><creatorcontrib>Federico, A</creatorcontrib><creatorcontrib>Matthews, P M</creatorcontrib><title>Altered cerebellar functional connectivity mediates potential adaptive plasticity in patients with multiple sclerosis</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>Background: The cerebellum is of potential interest for understanding adaptive responses in motor control in patients with multiple sclerosis because of the high intrinsic synaptic plasticity of this brain region. Objective: To assess the relative roles of interactions between the neocortex and the cerebellum using measures of functional connectivity. Methods: A role for altered neocortical–cerebellar functional connectivity in adaptive responses to injury from multiple sclerosis was tested using 1.5 T functional magnetic resonance imaging (fMRI) during figure writing with the dominant right hand in patients with predominantly early relapsing-remitting multiple sclerosis. Results: Patients (n = 14) showed a more bihemispheric pattern of activation in motor cortex than healthy controls (n = 11). Correlations between task related signal changes in neocortical and cerebellar regions of interest were used as a measure of functional connectivity. Healthy controls showed strong functional connectivity between the left motor cortex and the right cerebellar dentate nucleus. Significant connectivity between the left primary motor cortex and the right dentate was not found in patients. However, patients had significant connectivity between the left premotor neocortex and the ipsilateral (left) cerebellar cortex (crus I), which was not found in healthy controls. Conclusions: Changes in apparent cerebellar–neocortical functional connectivity may mediate potentially adaptive changes in brain motor control in patients with multiple sclerosis. Similar changes in the cerebellum and premotor cortex have been reported in the healthy brain during motor learning, suggesting that common mechanisms may contribute to normal motor learning and motor recovery after injury from multiple sclerosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>brain repair</subject><subject>Cerebellar Cortex - pathology</subject><subject>Cerebellar Cortex - physiology</subject><subject>cerebellum</subject><subject>Cerebellum - pathology</subject><subject>Cerebellum - physiology</subject><subject>Disease Progression</subject><subject>EDSS</subject><subject>expanded disability status score</subject><subject>Female</subject><subject>FLAME</subject><subject>FMRIB</subject><subject>FMRIB’s improved linear model</subject><subject>FMRIB’s local analysis of mixed effects</subject><subject>Functional Laterality - physiology</subject><subject>Hand - physiology</subject><subject>Humans</subject><subject>lateralisation index</subject><subject>Magnetic Resonance Imaging - 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pathology</topic><topic>Cerebellar Cortex - physiology</topic><topic>cerebellum</topic><topic>Cerebellum - pathology</topic><topic>Cerebellum - physiology</topic><topic>Disease Progression</topic><topic>EDSS</topic><topic>expanded disability status score</topic><topic>Female</topic><topic>FLAME</topic><topic>FMRIB</topic><topic>FMRIB’s improved linear model</topic><topic>FMRIB’s local analysis of mixed effects</topic><topic>Functional Laterality - physiology</topic><topic>Hand - physiology</topic><topic>Humans</topic><topic>lateralisation index</topic><topic>Magnetic Resonance Imaging - statistics & numerical data</topic><topic>Male</topic><topic>MCFLIRT</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>motion correction using FMIRB’s linear image registration tool</topic><topic>Motor Cortex - pathology</topic><topic>Motor Cortex - physiology</topic><topic>Movement - physiology</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Multiple Sclerosis - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saini, S</au><au>DeStefano, N</au><au>Smith, S</au><au>Guidi, L</au><au>Amato, M P</au><au>Federico, A</au><au>Matthews, P M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered cerebellar functional connectivity mediates potential adaptive plasticity in patients with multiple sclerosis</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>75</volume><issue>6</issue><spage>840</spage><epage>846</epage><pages>840-846</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>Background: The cerebellum is of potential interest for understanding adaptive responses in motor control in patients with multiple sclerosis because of the high intrinsic synaptic plasticity of this brain region. Objective: To assess the relative roles of interactions between the neocortex and the cerebellum using measures of functional connectivity. Methods: A role for altered neocortical–cerebellar functional connectivity in adaptive responses to injury from multiple sclerosis was tested using 1.5 T functional magnetic resonance imaging (fMRI) during figure writing with the dominant right hand in patients with predominantly early relapsing-remitting multiple sclerosis. Results: Patients (n = 14) showed a more bihemispheric pattern of activation in motor cortex than healthy controls (n = 11). Correlations between task related signal changes in neocortical and cerebellar regions of interest were used as a measure of functional connectivity. Healthy controls showed strong functional connectivity between the left motor cortex and the right cerebellar dentate nucleus. Significant connectivity between the left primary motor cortex and the right dentate was not found in patients. However, patients had significant connectivity between the left premotor neocortex and the ipsilateral (left) cerebellar cortex (crus I), which was not found in healthy controls. Conclusions: Changes in apparent cerebellar–neocortical functional connectivity may mediate potentially adaptive changes in brain motor control in patients with multiple sclerosis. Similar changes in the cerebellum and premotor cortex have been reported in the healthy brain during motor learning, suggesting that common mechanisms may contribute to normal motor learning and motor recovery after injury from multiple sclerosis.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>15145996</pmid><doi>10.1136/jnnp.2003.016782</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences brain repair Cerebellar Cortex - pathology Cerebellar Cortex - physiology cerebellum Cerebellum - pathology Cerebellum - physiology Disease Progression EDSS expanded disability status score Female FLAME FMRIB FMRIB’s improved linear model FMRIB’s local analysis of mixed effects Functional Laterality - physiology Hand - physiology Humans lateralisation index Magnetic Resonance Imaging - statistics & numerical data Male MCFLIRT Medical sciences Middle Aged motion correction using FMIRB’s linear image registration tool Motor Cortex - pathology Motor Cortex - physiology Movement - physiology Multiple sclerosis Multiple Sclerosis - diagnosis Multiple Sclerosis - pathology Neocortex - pathology Neocortex - physiology Neural Pathways - pathology Neural Pathways - physiology Neurology Neuronal Plasticity - physiology neurorehabilitation Oxford Centre for Functional Magnetic Resonance Imaging of the Brain Patients Psychomotor Performance - physiology region of interest ROI Scanners |
| title | Altered cerebellar functional connectivity mediates potential adaptive plasticity in patients with multiple sclerosis |
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