Genetically confirmed clinical Huntington’s disease with no observable cell loss

Huntington’s disease (HD) results from neurodegeneration of the neostriatum. The mutation on chromosome 4 is an expansion in a triplet repeat (CAG)n located within the IT15 gene. Only six patients have been reported with clinical features of HD in association with limited neuropathology. Of these, o...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2003-07, Vol.74 (7), p.968-970
Hauptverfasser:	Caramins, M, Halliday, G, McCusker, E, Trent, R J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggression Alcohol Autopsy Biological and medical sciences Brain Ischemia - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Deoxyribonucleic acid Disease Progression DNA Eye movements Families & family life Female Genetic aspects Genetic research Genetic testing Genotype & phenotype Globus Pallidus - pathology Humans Huntington Disease - genetics Huntington Disease - pathology Huntington's chorea Huntington’s disease Medical sciences Memory Disorders - etiology Middle Aged Mutation Neurology Neuropathology pathology Phenotype Short Report
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