Long term decline of P100 amplitude in migraine with aura
OBJECTIVES To investigate visual function in migraine using visual evoked potentials. METHODS Electroretinograms (ERGs) and visual evoked potentials (VEPs) to single flash (SF) and pattern reversal (PR) stimuli were studied in 92 migraine subjects and 62 controls. RESULTS In subjects with migraine,...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2000-10, Vol.69 (4), p.507-511 |
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| creator | Khalil, Nofal M Legg, Nigel J Anderson, Duncan J |
| description | OBJECTIVES To investigate visual function in migraine using visual evoked potentials. METHODS Electroretinograms (ERGs) and visual evoked potentials (VEPs) to single flash (SF) and pattern reversal (PR) stimuli were studied in 92 migraine subjects and 62 controls. RESULTS In subjects with migraine, ERGs to single flash were normal. Mean latencies of the P1 and P2 waves in the SFVEP were increased at the occiput by 6% and 4% respectively, but normal at the vertex. Mean latency of the P100 wave in the PRVEP was increased by 5%. These increases were not related to the presence or absence of an aura or to the duration of migraine. P100 amplitude showed a more complex abnormality. It was increased in migraine without aura by 23% compared with controls, regardless of duration of migraine. In migraine with aura it was similarly increased, by 23%, in cases of short duration, but in addition it showed a sharp decline with duration. In cases with a duration of 30 or more years it was 36% less than in cases of short duration, and 21% less than in controls. CONCLUSIONS Subjects with migraine have constitutionally prolonged VEP latencies and increased P100 amplitude, but the latter declines to below normal in cases with a long history of migraine with aura. This decline may reflect subtle neuronal damage within the visual system from repeated transient ischaemia experienced during the aura. Future electrophysiological and other studies will need to be controlled for duration of migraine history. |
| doi_str_mv | 10.1136/jnnp.69.4.507 |
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METHODS Electroretinograms (ERGs) and visual evoked potentials (VEPs) to single flash (SF) and pattern reversal (PR) stimuli were studied in 92 migraine subjects and 62 controls. RESULTS In subjects with migraine, ERGs to single flash were normal. Mean latencies of the P1 and P2 waves in the SFVEP were increased at the occiput by 6% and 4% respectively, but normal at the vertex. Mean latency of the P100 wave in the PRVEP was increased by 5%. These increases were not related to the presence or absence of an aura or to the duration of migraine. P100 amplitude showed a more complex abnormality. It was increased in migraine without aura by 23% compared with controls, regardless of duration of migraine. In migraine with aura it was similarly increased, by 23%, in cases of short duration, but in addition it showed a sharp decline with duration. In cases with a duration of 30 or more years it was 36% less than in cases of short duration, and 21% less than in controls. CONCLUSIONS Subjects with migraine have constitutionally prolonged VEP latencies and increased P100 amplitude, but the latter declines to below normal in cases with a long history of migraine with aura. This decline may reflect subtle neuronal damage within the visual system from repeated transient ischaemia experienced during the aura. Future electrophysiological and other studies will need to be controlled for duration of migraine history.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.69.4.507</identifier><identifier>PMID: 10990512</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Brain - physiopathology ; Electroencephalography ; Electroretinography ; Evoked Potentials, Visual - physiology ; Female ; Headaches ; Humans ; Male ; Medical sciences ; Middle Aged ; Migraine ; Migraine with Aura - physiopathology ; Neurology ; Photic Stimulation ; Reaction Time - physiology ; Variance analysis ; Vascular diseases and vascular malformations of the nervous system ; Visual acuity ; visual evoked potentials</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 2000-10, Vol.69 (4), p.507-511</ispartof><rights>Journal of Neurology, Neurosurgery, and Psychiatry</rights><rights>2000 INIST-CNRS</rights><rights>Copyright: 2000 Journal of Neurology, Neurosurgery, and Psychiatry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b540t-7ad71d8b285ecbfeeee4f60241fa5430421871e24712e5b0e36000b06a73cdda3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1737153/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1737153/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1486942$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10990512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khalil, Nofal M</creatorcontrib><creatorcontrib>Legg, Nigel J</creatorcontrib><creatorcontrib>Anderson, Duncan J</creatorcontrib><title>Long term decline of P100 amplitude in migraine with aura</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>OBJECTIVES To investigate visual function in migraine using visual evoked potentials. METHODS Electroretinograms (ERGs) and visual evoked potentials (VEPs) to single flash (SF) and pattern reversal (PR) stimuli were studied in 92 migraine subjects and 62 controls. RESULTS In subjects with migraine, ERGs to single flash were normal. Mean latencies of the P1 and P2 waves in the SFVEP were increased at the occiput by 6% and 4% respectively, but normal at the vertex. Mean latency of the P100 wave in the PRVEP was increased by 5%. These increases were not related to the presence or absence of an aura or to the duration of migraine. P100 amplitude showed a more complex abnormality. It was increased in migraine without aura by 23% compared with controls, regardless of duration of migraine. In migraine with aura it was similarly increased, by 23%, in cases of short duration, but in addition it showed a sharp decline with duration. In cases with a duration of 30 or more years it was 36% less than in cases of short duration, and 21% less than in controls. CONCLUSIONS Subjects with migraine have constitutionally prolonged VEP latencies and increased P100 amplitude, but the latter declines to below normal in cases with a long history of migraine with aura. This decline may reflect subtle neuronal damage within the visual system from repeated transient ischaemia experienced during the aura. Future electrophysiological and other studies will need to be controlled for duration of migraine history.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Brain - physiopathology</subject><subject>Electroencephalography</subject><subject>Electroretinography</subject><subject>Evoked Potentials, Visual - physiology</subject><subject>Female</subject><subject>Headaches</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Migraine</subject><subject>Migraine with Aura - physiopathology</subject><subject>Neurology</subject><subject>Photic Stimulation</subject><subject>Reaction Time - physiology</subject><subject>Variance analysis</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Visual acuity</subject><subject>visual evoked potentials</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc2L1EAQxRtR3HH16FUCinjJWNXfuSzI4Kow6B5WWbw0naQz22PSGbsTP_57e5hhd_ViXerwfrx6xSPkKcISkcnX2xB2S1kt-VKAukcWyKUuGYOr-2QBQGnJQMAJeZTSFvajq4fkBKGqQCBdkGo9hk0xuTgUrWt6H1wxdsUFAhR22PV-mltX-FAMfhPtXv3pp-vCztE-Jg862yf35LhPyefzt5er9-X607sPqzfrshYcplLZVmGra6qFa-rO5eGdBMqxs4Iz4BS1Qke5QupEDY7JnLIGaRVr2tayU3J28N3N9eDaxoUp2t7soh9s_G1G683fSvDXZjP-MKiYQsGywcujQRy_zy5NZvCpcX1vgxvnZBSlUoKCDD7_B9yOcwz5ueylUQhkGjNVHqgmjilF191EQTD7Ssy-EiMrw02uJPPP7ua_Qx86yMCLI2BTY_su2tD4dMtxLStOb-_6NLlfN7KN34zMnwrz8cvKfJX8anV-qc1F5l8d-HrY_ifiHzdvr10</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Khalil, Nofal M</creator><creator>Legg, Nigel J</creator><creator>Anderson, Duncan J</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20001001</creationdate><title>Long term decline of P100 amplitude in migraine with aura</title><author>Khalil, Nofal M ; Legg, Nigel J ; Anderson, Duncan J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b540t-7ad71d8b285ecbfeeee4f60241fa5430421871e24712e5b0e36000b06a73cdda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Brain - physiopathology</topic><topic>Electroencephalography</topic><topic>Electroretinography</topic><topic>Evoked Potentials, Visual - physiology</topic><topic>Female</topic><topic>Headaches</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Migraine</topic><topic>Migraine with Aura - physiopathology</topic><topic>Neurology</topic><topic>Photic Stimulation</topic><topic>Reaction Time - physiology</topic><topic>Variance analysis</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Visual acuity</topic><topic>visual evoked potentials</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khalil, Nofal M</creatorcontrib><creatorcontrib>Legg, Nigel J</creatorcontrib><creatorcontrib>Anderson, Duncan J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khalil, Nofal M</au><au>Legg, Nigel J</au><au>Anderson, Duncan J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long term decline of P100 amplitude in migraine with aura</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>69</volume><issue>4</issue><spage>507</spage><epage>511</epage><pages>507-511</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>OBJECTIVES To investigate visual function in migraine using visual evoked potentials. METHODS Electroretinograms (ERGs) and visual evoked potentials (VEPs) to single flash (SF) and pattern reversal (PR) stimuli were studied in 92 migraine subjects and 62 controls. RESULTS In subjects with migraine, ERGs to single flash were normal. Mean latencies of the P1 and P2 waves in the SFVEP were increased at the occiput by 6% and 4% respectively, but normal at the vertex. Mean latency of the P100 wave in the PRVEP was increased by 5%. These increases were not related to the presence or absence of an aura or to the duration of migraine. P100 amplitude showed a more complex abnormality. It was increased in migraine without aura by 23% compared with controls, regardless of duration of migraine. In migraine with aura it was similarly increased, by 23%, in cases of short duration, but in addition it showed a sharp decline with duration. In cases with a duration of 30 or more years it was 36% less than in cases of short duration, and 21% less than in controls. CONCLUSIONS Subjects with migraine have constitutionally prolonged VEP latencies and increased P100 amplitude, but the latter declines to below normal in cases with a long history of migraine with aura. This decline may reflect subtle neuronal damage within the visual system from repeated transient ischaemia experienced during the aura. Future electrophysiological and other studies will need to be controlled for duration of migraine history.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>10990512</pmid><doi>10.1136/jnnp.69.4.507</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Brain - physiopathology Electroencephalography Electroretinography Evoked Potentials, Visual - physiology Female Headaches Humans Male Medical sciences Middle Aged Migraine Migraine with Aura - physiopathology Neurology Photic Stimulation Reaction Time - physiology Variance analysis Vascular diseases and vascular malformations of the nervous system Visual acuity visual evoked potentials |
| title | Long term decline of P100 amplitude in migraine with aura |
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