Anti-amphiphysin I antibodies in patients with paraneoplastic neurological disorders associated with small cell lung carcinoma
Patients with stiff man syndrome and breast cancer develop anti-amphiphysin I antibodies that primarily recognise the C terminus of the protein. Anti-amphiphysin I antibodies have also been identified in a few patients with paraneoplastic neurological disorders (PND) and small cell lung cancer (SCLC...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1999-02, Vol.66 (2), p.214-217 |
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| creator | Saiz, A Dalmau, J Butler, M Husta Chen, Q Delattre, J Y De Camilli, P Graus, F |
| description | Patients with stiff man syndrome and breast cancer develop anti-amphiphysin I antibodies that primarily recognise the C terminus of the protein. Anti-amphiphysin I antibodies have also been identified in a few patients with paraneoplastic neurological disorders (PND) and small cell lung cancer (SCLC). The frequency of anti-amphiphysin I antibodies in patients with SCLC and PND was analysed and the epitope specificity of these antibodies was characterised. Anti-amphiphysin I antibodies were evaluated by immunohistochemistry on human and rat cerebellum and immunoblots of rat brain homogenates. Serum samples included 134 patients with PND and anti-Hu antibodies (83% had SCLC), 44 with SCLC and PND without antiHu-antibodies, 63 with PND and either Yo, Ri, or Tr antibodies, 146 with SCLC without PND, and 104 with non-PND. Positive serum samples were confirmed with immunoblots of recombinant human amphiphysin I and immunoreacted with five overlapping peptide fragments covering the full length of the molecule. Serum samples positive for anti-amphiphysin I antibodies included those from seven (2.9%) patients with PND and two (1.4%) with SCLC without PND. Six of the seven anti-amphiphysin I antibody positive patients with PND had SCLC (three with Hu-antibodies), and one had anti-Hu-antibodies but no detectable tumour. The PND included encephalomyelitis/sensory neuropathy (five patients), cerebellar degeneration (one), and opsoclonus (one). All anti-amphiphysin I antibodies reacted with the C terminus of amphiphysin I, but seven also recognised other fragments of the molecule. In conclusion, anti-amphiphysin I antibodies are present at low frequency in patients with SCLC irrespective of the presence of an associated PND. All anti-amphiphysin I antibody positive serum samples have in common reactivity with the C terminus of the protein. |
| doi_str_mv | 10.1136/jnnp.66.2.214 |
| format | Article |
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Anti-amphiphysin I antibodies have also been identified in a few patients with paraneoplastic neurological disorders (PND) and small cell lung cancer (SCLC). The frequency of anti-amphiphysin I antibodies in patients with SCLC and PND was analysed and the epitope specificity of these antibodies was characterised. Anti-amphiphysin I antibodies were evaluated by immunohistochemistry on human and rat cerebellum and immunoblots of rat brain homogenates. Serum samples included 134 patients with PND and anti-Hu antibodies (83% had SCLC), 44 with SCLC and PND without antiHu-antibodies, 63 with PND and either Yo, Ri, or Tr antibodies, 146 with SCLC without PND, and 104 with non-PND. Positive serum samples were confirmed with immunoblots of recombinant human amphiphysin I and immunoreacted with five overlapping peptide fragments covering the full length of the molecule. Serum samples positive for anti-amphiphysin I antibodies included those from seven (2.9%) patients with PND and two (1.4%) with SCLC without PND. Six of the seven anti-amphiphysin I antibody positive patients with PND had SCLC (three with Hu-antibodies), and one had anti-Hu-antibodies but no detectable tumour. The PND included encephalomyelitis/sensory neuropathy (five patients), cerebellar degeneration (one), and opsoclonus (one). All anti-amphiphysin I antibodies reacted with the C terminus of amphiphysin I, but seven also recognised other fragments of the molecule. In conclusion, anti-amphiphysin I antibodies are present at low frequency in patients with SCLC irrespective of the presence of an associated PND. All anti-amphiphysin I antibody positive serum samples have in common reactivity with the C terminus of the protein.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.66.2.214</identifier><identifier>PMID: 10071102</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Aged ; amphiphysin I ; Animals ; Antibodies - immunology ; autoantibodies ; Biological and medical sciences ; Carcinoma, Small Cell - immunology ; Female ; Humans ; Immunoblotting ; Immunohistochemistry ; Lung Neoplasms - immunology ; Male ; Medical sciences ; Middle Aged ; Nerve Tissue Proteins - immunology ; Nervous System Diseases - immunology ; Neurological disorders ; paraneoplastic ; Paraneoplastic Syndromes - immunology ; Pneumology ; Rats ; Short Report ; small cell lung carcinoma ; stiff man syndrome ; Tumors of the respiratory system and mediastinum</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 1999-02, Vol.66 (2), p.214-217</ispartof><rights>Journal of Neurology, Neurosurgery, and Psychiatry</rights><rights>1999 INIST-CNRS</rights><rights>Copyright: 1999 Journal of Neurology, Neurosurgery, and Psychiatry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b511t-e88c2b2653fcb421ae69e5c4c0d41c9a6b50ded82dbf24a2335ed6b07a1ef3aa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1736210/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1736210/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1657808$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10071102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saiz, A</creatorcontrib><creatorcontrib>Dalmau, J</creatorcontrib><creatorcontrib>Butler, M Husta</creatorcontrib><creatorcontrib>Chen, Q</creatorcontrib><creatorcontrib>Delattre, J Y</creatorcontrib><creatorcontrib>De Camilli, P</creatorcontrib><creatorcontrib>Graus, F</creatorcontrib><title>Anti-amphiphysin I antibodies in patients with paraneoplastic neurological disorders associated with small cell lung carcinoma</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>Patients with stiff man syndrome and breast cancer develop anti-amphiphysin I antibodies that primarily recognise the C terminus of the protein. Anti-amphiphysin I antibodies have also been identified in a few patients with paraneoplastic neurological disorders (PND) and small cell lung cancer (SCLC). The frequency of anti-amphiphysin I antibodies in patients with SCLC and PND was analysed and the epitope specificity of these antibodies was characterised. Anti-amphiphysin I antibodies were evaluated by immunohistochemistry on human and rat cerebellum and immunoblots of rat brain homogenates. Serum samples included 134 patients with PND and anti-Hu antibodies (83% had SCLC), 44 with SCLC and PND without antiHu-antibodies, 63 with PND and either Yo, Ri, or Tr antibodies, 146 with SCLC without PND, and 104 with non-PND. Positive serum samples were confirmed with immunoblots of recombinant human amphiphysin I and immunoreacted with five overlapping peptide fragments covering the full length of the molecule. Serum samples positive for anti-amphiphysin I antibodies included those from seven (2.9%) patients with PND and two (1.4%) with SCLC without PND. Six of the seven anti-amphiphysin I antibody positive patients with PND had SCLC (three with Hu-antibodies), and one had anti-Hu-antibodies but no detectable tumour. The PND included encephalomyelitis/sensory neuropathy (five patients), cerebellar degeneration (one), and opsoclonus (one). All anti-amphiphysin I antibodies reacted with the C terminus of amphiphysin I, but seven also recognised other fragments of the molecule. In conclusion, anti-amphiphysin I antibodies are present at low frequency in patients with SCLC irrespective of the presence of an associated PND. All anti-amphiphysin I antibody positive serum samples have in common reactivity with the C terminus of the protein.</description><subject>Aged</subject><subject>amphiphysin I</subject><subject>Animals</subject><subject>Antibodies - immunology</subject><subject>autoantibodies</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Small Cell - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Immunohistochemistry</subject><subject>Lung Neoplasms - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nerve Tissue Proteins - immunology</subject><subject>Nervous System Diseases - immunology</subject><subject>Neurological disorders</subject><subject>paraneoplastic</subject><subject>Paraneoplastic Syndromes - immunology</subject><subject>Pneumology</subject><subject>Rats</subject><subject>Short Report</subject><subject>small cell lung carcinoma</subject><subject>stiff man syndrome</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc-P1CAUx4nRuOPo0atpojFeOvKg0M5lk83EH5ts1MTVGC_kldIZxhYqtOpe_Nulmcnu6kUOkAcfvnwfX0IeA10BcPly79ywknLFVgyKO2QBhaxyzumXu2RBKWM5p4KekAcx7uk8qvV9cgKUlgCULcjvMzfaHPthZ4fdVbQuO88wbdW-sSZmqR5wtMaNMftpx12qAjrjhw7jaHXmzBR857dWY5c1NvrQmBAzjNFri6NpDrdij12XaZOmbnLbTGPQ1vkeH5J7LXbRPDquS_Lp9avLzdv84v2b883ZRV4LgDE3VaVZzaTgra4LBmjk2ghdaNoUoNcoa0Eb01SsqVtWIONcmEbWtEQwLUfkS3J60B2mujeNTg0F7NQQbI_hSnm06u8TZ3dq638oKLlkQJPA86NA8N8nE0fV2zg3NP_GFJVcS4B1MrgkT_8B934KLjWXtCoQILjgicoPlA4-xmDaaytA1ZyrmnNVUiqmUq6Jf3Lb_y36EGQCnh0BjCmLNqWkbbzhpCgrWt28a-Nofl0fY_imZMlLod593qiP5YcNwNdLNft8ceDrfv8fi38ATSLMKw</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>Saiz, A</creator><creator>Dalmau, J</creator><creator>Butler, M Husta</creator><creator>Chen, Q</creator><creator>Delattre, J Y</creator><creator>De Camilli, P</creator><creator>Graus, F</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19990201</creationdate><title>Anti-amphiphysin I antibodies in patients with paraneoplastic neurological disorders associated with small cell lung carcinoma</title><author>Saiz, A ; Dalmau, J ; Butler, M Husta ; Chen, Q ; Delattre, J Y ; De Camilli, P ; Graus, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b511t-e88c2b2653fcb421ae69e5c4c0d41c9a6b50ded82dbf24a2335ed6b07a1ef3aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aged</topic><topic>amphiphysin I</topic><topic>Animals</topic><topic>Antibodies - immunology</topic><topic>autoantibodies</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Small Cell - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Immunohistochemistry</topic><topic>Lung Neoplasms - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nerve Tissue Proteins - immunology</topic><topic>Nervous System Diseases - immunology</topic><topic>Neurological disorders</topic><topic>paraneoplastic</topic><topic>Paraneoplastic Syndromes - immunology</topic><topic>Pneumology</topic><topic>Rats</topic><topic>Short Report</topic><topic>small cell lung carcinoma</topic><topic>stiff man syndrome</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saiz, A</creatorcontrib><creatorcontrib>Dalmau, J</creatorcontrib><creatorcontrib>Butler, M Husta</creatorcontrib><creatorcontrib>Chen, Q</creatorcontrib><creatorcontrib>Delattre, J Y</creatorcontrib><creatorcontrib>De Camilli, P</creatorcontrib><creatorcontrib>Graus, F</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saiz, A</au><au>Dalmau, J</au><au>Butler, M Husta</au><au>Chen, Q</au><au>Delattre, J Y</au><au>De Camilli, P</au><au>Graus, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-amphiphysin I antibodies in patients with paraneoplastic neurological disorders associated with small cell lung carcinoma</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>66</volume><issue>2</issue><spage>214</spage><epage>217</epage><pages>214-217</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>Patients with stiff man syndrome and breast cancer develop anti-amphiphysin I antibodies that primarily recognise the C terminus of the protein. Anti-amphiphysin I antibodies have also been identified in a few patients with paraneoplastic neurological disorders (PND) and small cell lung cancer (SCLC). The frequency of anti-amphiphysin I antibodies in patients with SCLC and PND was analysed and the epitope specificity of these antibodies was characterised. Anti-amphiphysin I antibodies were evaluated by immunohistochemistry on human and rat cerebellum and immunoblots of rat brain homogenates. Serum samples included 134 patients with PND and anti-Hu antibodies (83% had SCLC), 44 with SCLC and PND without antiHu-antibodies, 63 with PND and either Yo, Ri, or Tr antibodies, 146 with SCLC without PND, and 104 with non-PND. Positive serum samples were confirmed with immunoblots of recombinant human amphiphysin I and immunoreacted with five overlapping peptide fragments covering the full length of the molecule. Serum samples positive for anti-amphiphysin I antibodies included those from seven (2.9%) patients with PND and two (1.4%) with SCLC without PND. Six of the seven anti-amphiphysin I antibody positive patients with PND had SCLC (three with Hu-antibodies), and one had anti-Hu-antibodies but no detectable tumour. The PND included encephalomyelitis/sensory neuropathy (five patients), cerebellar degeneration (one), and opsoclonus (one). All anti-amphiphysin I antibodies reacted with the C terminus of amphiphysin I, but seven also recognised other fragments of the molecule. In conclusion, anti-amphiphysin I antibodies are present at low frequency in patients with SCLC irrespective of the presence of an associated PND. All anti-amphiphysin I antibody positive serum samples have in common reactivity with the C terminus of the protein.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>10071102</pmid><doi>10.1136/jnnp.66.2.214</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of neurology, neurosurgery and psychiatry, 1999-02, Vol.66 (2), p.214-217 |
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| language | eng |
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| subjects | Aged amphiphysin I Animals Antibodies - immunology autoantibodies Biological and medical sciences Carcinoma, Small Cell - immunology Female Humans Immunoblotting Immunohistochemistry Lung Neoplasms - immunology Male Medical sciences Middle Aged Nerve Tissue Proteins - immunology Nervous System Diseases - immunology Neurological disorders paraneoplastic Paraneoplastic Syndromes - immunology Pneumology Rats Short Report small cell lung carcinoma stiff man syndrome Tumors of the respiratory system and mediastinum |
| title | Anti-amphiphysin I antibodies in patients with paraneoplastic neurological disorders associated with small cell lung carcinoma |
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