Cytosine methylation confers instability on the cardiac troponin T gene in hypertrophic cardiomyopathy

Subjects with HCM caused by mutations in the cardiac troponin T (cTNT) gene have been clinically shown to be at increased risk of sudden death, 6 which may occur even in the absence of marked morphological abnormalities. 7 Since incomplete penetrance of the clinical phenotype, measured by ECG and ec...

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