Novel germline mutations in the PTEN tumour suppressor gene found in women with multiple cancers

Germline mutations in PTEN can predispose people to Cowden syndrome (CS) and Bannayan-Ruvalcaba-Riley (BRR) syndrome, rare, autosomal dominantly inherited neoplastic disorders. To determine whether germline mutations in PTEN contribute to genetic predisposition to multiple primary tumours within the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medical genetics 2000-05, Vol.37 (5), p.336-341
Hauptverfasser:	DE VIVO, I, GERTIG, D. M, NAGASE, S, HANKINSON, S. E, O'BRIEN, R, SPEIZER, F. E, PARSONS, R, HUNTER, D. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Breast Neoplasms - metabolism Carcinogenesis, carcinogens and anticarcinogens Case-Control Studies Cohort Studies Exons - genetics Female General aspects Genes, Tumor Suppressor Germ-Line Mutation Health Surveys Humans Medical sciences Middle Aged Neoplasms, Multiple Primary - genetics Nurses Original Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Phylogeny Polymorphism, Single-Stranded Conformational PTEN Phosphohydrolase Sequence Analysis, DNA Tumor Cells, Cultured Tumor Suppressor Proteins Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!