No sequence variation in part of the hexon and the fibre genes of adenovirus 8 isolated from patients with conjunctivitis or epidemic keratoconjunctivitis (EKC) in Norway during 1989 to 1996
Background/Aims—Several local epidemics of keratoconjunctivitis/conjunctivitis caused by adenovirus type 8 (Ad8) occurred in Norway from August 1995 to May 1996. A smaller epidemic occurred in 1992. The Ad8 hexon forms the surface of the virion and contains the hypervariable regions loop I1 and loop...
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| Veröffentlicht in: | Journal of clinical pathology 2001-07, Vol.54 (7), p.558-561 |
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| description | Background/Aims—Several local epidemics of keratoconjunctivitis/conjunctivitis caused by adenovirus type 8 (Ad8) occurred in Norway from August 1995 to May 1996. A smaller epidemic occurred in 1992. The Ad8 hexon forms the surface of the virion and contains the hypervariable regions loop I1 and loop I2. The fibre mediates the primary contact with cells. Sequence variation in hexon and fibre genes might play an important role in the pathogenicity of adenoviruses. The aim of this study was to investigate the genetic variability at the hexon and fibre genes in 26 strains of Ad8 isolated from 1989 to 1996. Methods—The genetic variability of 26 strains of Ad8 isolated from 1989 to 1996 was studied by sequencing part of the hexon and fibre genes. The Ad8 sequences were compared with each other and with two Ad8 strains from the EMBL database. In addition, 14 of the 26 isolates were subjected to restriction endonuclease analysis. Results—No significant sequence variation was seen during the six year period. Conclusion—The Ad8 strains causing epidemics of keratoconjunctivitis/conjunctivitis in Norway are genetically stable. |
| doi_str_mv | 10.1136/jcp.54.7.558 |
| format | Article |
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A smaller epidemic occurred in 1992. The Ad8 hexon forms the surface of the virion and contains the hypervariable regions loop I1 and loop I2. The fibre mediates the primary contact with cells. Sequence variation in hexon and fibre genes might play an important role in the pathogenicity of adenoviruses. The aim of this study was to investigate the genetic variability at the hexon and fibre genes in 26 strains of Ad8 isolated from 1989 to 1996. Methods—The genetic variability of 26 strains of Ad8 isolated from 1989 to 1996 was studied by sequencing part of the hexon and fibre genes. The Ad8 sequences were compared with each other and with two Ad8 strains from the EMBL database. In addition, 14 of the 26 isolates were subjected to restriction endonuclease analysis. Results—No significant sequence variation was seen during the six year period. Conclusion—The Ad8 strains causing epidemics of keratoconjunctivitis/conjunctivitis in Norway are genetically stable.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.54.7.558</identifier><identifier>PMID: 11429431</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>adenovirus 8 ; Adenovirus Infections, Human - epidemiology ; Adenovirus Infections, Human - virology ; Adenoviruses, Human ; Adenoviruses, Human - classification ; Adenoviruses, Human - genetics ; Adenoviruses, Human - isolation & purification ; Antigens, Viral - genetics ; Biological and medical sciences ; Capsid - genetics ; Capsid Proteins ; Causes of ; Conjunctivitis ; Conjunctivitis, Viral - epidemiology ; Conjunctivitis, Viral - virology ; Disease Outbreaks ; DNA, Viral - genetics ; Genetic Variation ; Human viral diseases ; Humans ; Infectious diseases ; Keratoconjunctivitis ; Keratoconjunctivitis, Infectious - epidemiology ; Keratoconjunctivitis, Infectious - virology ; Medical sciences ; molecular epidemiology ; Norway - epidemiology ; Phylogeny ; Sequence Analysis, DNA ; Short Report ; Viral diseases ; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><ispartof>Journal of clinical pathology, 2001-07, Vol.54 (7), p.558-561</ispartof><rights>COPYRIGHT © 2001 Journal of Clinical Pathology</rights><rights>2001 INIST-CNRS</rights><rights>COPYRIGHT 2001 BMJ Publishing Group Ltd.</rights><rights>Copyright: 2001 COPYRIGHT (c) 2001 Journal of Clinical Pathology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b582t-41b00847e81dbde2bb06dc748291898bdb5013604772892158ae96b68c22c05a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1731479/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1731479/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1083204$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11429431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vainio, K</creatorcontrib><creatorcontrib>Borch, E</creatorcontrib><creatorcontrib>Bruu, A L</creatorcontrib><title>No sequence variation in part of the hexon and the fibre genes of adenovirus 8 isolated from patients with conjunctivitis or epidemic keratoconjunctivitis (EKC) in Norway during 1989 to 1996</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>Background/Aims—Several local epidemics of keratoconjunctivitis/conjunctivitis caused by adenovirus type 8 (Ad8) occurred in Norway from August 1995 to May 1996. A smaller epidemic occurred in 1992. The Ad8 hexon forms the surface of the virion and contains the hypervariable regions loop I1 and loop I2. The fibre mediates the primary contact with cells. Sequence variation in hexon and fibre genes might play an important role in the pathogenicity of adenoviruses. The aim of this study was to investigate the genetic variability at the hexon and fibre genes in 26 strains of Ad8 isolated from 1989 to 1996. Methods—The genetic variability of 26 strains of Ad8 isolated from 1989 to 1996 was studied by sequencing part of the hexon and fibre genes. The Ad8 sequences were compared with each other and with two Ad8 strains from the EMBL database. In addition, 14 of the 26 isolates were subjected to restriction endonuclease analysis. Results—No significant sequence variation was seen during the six year period. Conclusion—The Ad8 strains causing epidemics of keratoconjunctivitis/conjunctivitis in Norway are genetically stable.</description><subject>adenovirus 8</subject><subject>Adenovirus Infections, Human - epidemiology</subject><subject>Adenovirus Infections, Human - virology</subject><subject>Adenoviruses, Human</subject><subject>Adenoviruses, Human - classification</subject><subject>Adenoviruses, Human - genetics</subject><subject>Adenoviruses, Human - isolation & purification</subject><subject>Antigens, Viral - genetics</subject><subject>Biological and medical sciences</subject><subject>Capsid - genetics</subject><subject>Capsid Proteins</subject><subject>Causes of</subject><subject>Conjunctivitis</subject><subject>Conjunctivitis, Viral - epidemiology</subject><subject>Conjunctivitis, Viral - virology</subject><subject>Disease Outbreaks</subject><subject>DNA, Viral - genetics</subject><subject>Genetic Variation</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Keratoconjunctivitis</subject><subject>Keratoconjunctivitis, Infectious - epidemiology</subject><subject>Keratoconjunctivitis, Infectious - virology</subject><subject>Medical sciences</subject><subject>molecular epidemiology</subject><subject>Norway - epidemiology</subject><subject>Phylogeny</subject><subject>Sequence Analysis, DNA</subject><subject>Short Report</subject><subject>Viral diseases</subject><subject>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kttuEzEQhlcIREvhjmtkiYqDRIK9J9s3SFVUDqIECXG4tLze2cTpxg62N21fjmdj0kRtqSrki5E9n3_P_J4se8romLGifrswq3FVjvm4qsS9bJ-VPB-VrKzvZ_uU5mwkeVnvZY9iXFDKCs6Kh9keY2Uuy4LtZ3-mnkT4PYAzQNY6WJ2sd8Q6stIhEd-RNAcyh3M81K693HW2CUBm4CBuAN2C82sbhkgEsdH3OkFLuuCXqJEsuBTJmU1zYrxbDM4ku7bJ4tVAYGVbWFpDTiHo5G8Br44_T15vSpn6cKYvSDsE62aESSFJ8hhl_Th70Ok-wpNdPMh-vD_-Pvk4Ovn64dPk6GTUVCJP6EdDqSg5CNY2LeRNQ-vW8FLkkgkpmrap0JualpznQuasEhpk3dTC5LmhlS4Osndb3dXQLKE12FTQvVoFu9ThQnlt1b8ZZ-dq5teK8QJ_RKLAi51A8Oh2TGppo4G-1w78EBWnsqKyEAg-vwUu_BAcNodagjGsraBIvdlSM92Dsq7z-KrZfAk-7h10Fo-POKeCySpHfHQHjuvS_bv4nbwJPsYA3VWnjKrN1CmcOlWViiucOsSf3XTnGt6NGQKHO0BHo_suaGdsvCEqipyW12XamOD8Kq3Dqap5wSs1_TlRtZhK-U18Ub-Qf7nlm-Xi_xX-BYdO_IE</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>Vainio, K</creator><creator>Borch, E</creator><creator>Bruu, A L</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ</general><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20010701</creationdate><title>No sequence variation in part of the hexon and the fibre genes of adenovirus 8 isolated from patients with conjunctivitis or epidemic keratoconjunctivitis (EKC) in Norway during 1989 to 1996</title><author>Vainio, K ; Borch, E ; Bruu, A L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b582t-41b00847e81dbde2bb06dc748291898bdb5013604772892158ae96b68c22c05a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>adenovirus 8</topic><topic>Adenovirus Infections, Human - epidemiology</topic><topic>Adenovirus Infections, Human - virology</topic><topic>Adenoviruses, Human</topic><topic>Adenoviruses, Human - classification</topic><topic>Adenoviruses, Human - genetics</topic><topic>Adenoviruses, Human - isolation & purification</topic><topic>Antigens, Viral - genetics</topic><topic>Biological and medical sciences</topic><topic>Capsid - genetics</topic><topic>Capsid Proteins</topic><topic>Causes of</topic><topic>Conjunctivitis</topic><topic>Conjunctivitis, Viral - epidemiology</topic><topic>Conjunctivitis, Viral - virology</topic><topic>Disease Outbreaks</topic><topic>DNA, Viral - genetics</topic><topic>Genetic Variation</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Keratoconjunctivitis</topic><topic>Keratoconjunctivitis, Infectious - epidemiology</topic><topic>Keratoconjunctivitis, Infectious - virology</topic><topic>Medical sciences</topic><topic>molecular epidemiology</topic><topic>Norway - epidemiology</topic><topic>Phylogeny</topic><topic>Sequence Analysis, DNA</topic><topic>Short Report</topic><topic>Viral diseases</topic><topic>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vainio, K</creatorcontrib><creatorcontrib>Borch, E</creatorcontrib><creatorcontrib>Bruu, A L</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vainio, K</au><au>Borch, E</au><au>Bruu, A L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No sequence variation in part of the hexon and the fibre genes of adenovirus 8 isolated from patients with conjunctivitis or epidemic keratoconjunctivitis (EKC) in Norway during 1989 to 1996</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>54</volume><issue>7</issue><spage>558</spage><epage>561</epage><pages>558-561</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><coden>JCPAAK</coden><abstract>Background/Aims—Several local epidemics of keratoconjunctivitis/conjunctivitis caused by adenovirus type 8 (Ad8) occurred in Norway from August 1995 to May 1996. A smaller epidemic occurred in 1992. The Ad8 hexon forms the surface of the virion and contains the hypervariable regions loop I1 and loop I2. The fibre mediates the primary contact with cells. Sequence variation in hexon and fibre genes might play an important role in the pathogenicity of adenoviruses. The aim of this study was to investigate the genetic variability at the hexon and fibre genes in 26 strains of Ad8 isolated from 1989 to 1996. Methods—The genetic variability of 26 strains of Ad8 isolated from 1989 to 1996 was studied by sequencing part of the hexon and fibre genes. The Ad8 sequences were compared with each other and with two Ad8 strains from the EMBL database. In addition, 14 of the 26 isolates were subjected to restriction endonuclease analysis. Results—No significant sequence variation was seen during the six year period. Conclusion—The Ad8 strains causing epidemics of keratoconjunctivitis/conjunctivitis in Norway are genetically stable.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>11429431</pmid><doi>10.1136/jcp.54.7.558</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of clinical pathology, 2001-07, Vol.54 (7), p.558-561 |
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| subjects | adenovirus 8 Adenovirus Infections, Human - epidemiology Adenovirus Infections, Human - virology Adenoviruses, Human Adenoviruses, Human - classification Adenoviruses, Human - genetics Adenoviruses, Human - isolation & purification Antigens, Viral - genetics Biological and medical sciences Capsid - genetics Capsid Proteins Causes of Conjunctivitis Conjunctivitis, Viral - epidemiology Conjunctivitis, Viral - virology Disease Outbreaks DNA, Viral - genetics Genetic Variation Human viral diseases Humans Infectious diseases Keratoconjunctivitis Keratoconjunctivitis, Infectious - epidemiology Keratoconjunctivitis, Infectious - virology Medical sciences molecular epidemiology Norway - epidemiology Phylogeny Sequence Analysis, DNA Short Report Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye |
| title | No sequence variation in part of the hexon and the fibre genes of adenovirus 8 isolated from patients with conjunctivitis or epidemic keratoconjunctivitis (EKC) in Norway during 1989 to 1996 |
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