The prognostic relevance of angiogenesis and mast cells in squamous cell carcinoma of the oesophagus
Aims—Angiogenesis, an important prognostic factor in several tumours, is a complex event mediated by angiogenic factors released from cancer cells and host immune cells. Among the host immune cells, a role has been implicated for mast cells in tumour progression via promoting angiogenesis. Data have...
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| Veröffentlicht in: | Journal of clinical pathology 2001-12, Vol.54 (12), p.940-944 |
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| creator | Elpek, G Ö Gelen, T Aksoy, N H Erdoğan, A Dertsiz, L Demircan, A Keleş, N |
| description | Aims—Angiogenesis, an important prognostic factor in several tumours, is a complex event mediated by angiogenic factors released from cancer cells and host immune cells. Among the host immune cells, a role has been implicated for mast cells in tumour progression via promoting angiogenesis. Data have been recorded that indicate a correlation between intratumoral neovascularisation, as assessed by microvessel density (MVD), and prognosis in squamous cell carcinoma (SCC) of the oesophagus. However, a correlation between mast cell density (MCD) and either prognosis or angiogenesis has not been delineated yet in this disease. The aim of this study was to investigate the prognostic value of MVD and MCD in SCC of the oesophagus. The correlation between MVD and MCD was also evaluated. Methods—MVD and MCD were investigated in tumour specimens from 53 patients diagnosed with SCC of the oesophagus. Intratumoral microvessels were stained with anti-CD34 antibody and mast cells with toluidine blue before being measured by light microscopy. Results—Both MVD and MCD were associated with the depth of wall invasion, lymph node metastasis, and tumour progression (stage). A significant correlation was noted between MVD and MCD values (r = 0.72). The prognosis was significantly worse in patients with high MVD (≥ 92) and high MCD (≥ 18) values. Multivariate analysis indicated that MVD and stage were independent predictors of survival. Conclusions—These findings support the suggestion that MVD is a reliable prognostic marker in SCC of the oesophagus. Moreover, MCD may have a role in the angiogenesis of these tumours and might be responsible for their aggressive behaviour. |
| doi_str_mv | 10.1136/jcp.54.12.940 |
| format | Article |
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Among the host immune cells, a role has been implicated for mast cells in tumour progression via promoting angiogenesis. Data have been recorded that indicate a correlation between intratumoral neovascularisation, as assessed by microvessel density (MVD), and prognosis in squamous cell carcinoma (SCC) of the oesophagus. However, a correlation between mast cell density (MCD) and either prognosis or angiogenesis has not been delineated yet in this disease. The aim of this study was to investigate the prognostic value of MVD and MCD in SCC of the oesophagus. The correlation between MVD and MCD was also evaluated. Methods—MVD and MCD were investigated in tumour specimens from 53 patients diagnosed with SCC of the oesophagus. Intratumoral microvessels were stained with anti-CD34 antibody and mast cells with toluidine blue before being measured by light microscopy. Results—Both MVD and MCD were associated with the depth of wall invasion, lymph node metastasis, and tumour progression (stage). A significant correlation was noted between MVD and MCD values (r = 0.72). The prognosis was significantly worse in patients with high MVD (≥ 92) and high MCD (≥ 18) values. Multivariate analysis indicated that MVD and stage were independent predictors of survival. Conclusions—These findings support the suggestion that MVD is a reliable prognostic marker in SCC of the oesophagus. Moreover, MCD may have a role in the angiogenesis of these tumours and might be responsible for their aggressive behaviour.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.54.12.940</identifier><identifier>PMID: 11729214</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Adult ; Angiogenesis ; Antibodies ; Antigens, CD34 - analysis ; Biological and medical sciences ; Carcinoma, Squamous Cell - blood supply ; Carcinoma, Squamous Cell - immunology ; Carcinoma, Squamous Cell - surgery ; Cell Count ; Esophageal cancer ; Esophageal Neoplasms - blood supply ; Esophageal Neoplasms - immunology ; Esophageal Neoplasms - surgery ; Esophagus ; Female ; Follow-Up Studies ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Lymphatic system ; Male ; mast cell ; Mast Cells - pathology ; Medical prognosis ; Medical sciences ; Metastasis ; Microcirculation ; microvessel density ; Middle Aged ; Neovascularization ; Neovascularization, Pathologic - pathology ; oesophagus ; Physiological aspects ; Prognosis ; Squamous cell carcinoma ; Surgery ; Survival Analysis ; Tumors</subject><ispartof>Journal of clinical pathology, 2001-12, Vol.54 (12), p.940-944</ispartof><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2001 BMJ Publishing Group Ltd.</rights><rights>COPYRIGHT © 2001 Journal of Clinical Pathology 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-42fff9fe66c0805558974cbf5495ab14598cff756d563bcc8d821354d0630b7f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1731336/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1731336/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14122308$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11729214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elpek, G Ö</creatorcontrib><creatorcontrib>Gelen, T</creatorcontrib><creatorcontrib>Aksoy, N H</creatorcontrib><creatorcontrib>Erdoğan, A</creatorcontrib><creatorcontrib>Dertsiz, L</creatorcontrib><creatorcontrib>Demircan, A</creatorcontrib><creatorcontrib>Keleş, N</creatorcontrib><title>The prognostic relevance of angiogenesis and mast cells in squamous cell carcinoma of the oesophagus</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>Aims—Angiogenesis, an important prognostic factor in several tumours, is a complex event mediated by angiogenic factors released from cancer cells and host immune cells. Among the host immune cells, a role has been implicated for mast cells in tumour progression via promoting angiogenesis. Data have been recorded that indicate a correlation between intratumoral neovascularisation, as assessed by microvessel density (MVD), and prognosis in squamous cell carcinoma (SCC) of the oesophagus. However, a correlation between mast cell density (MCD) and either prognosis or angiogenesis has not been delineated yet in this disease. The aim of this study was to investigate the prognostic value of MVD and MCD in SCC of the oesophagus. The correlation between MVD and MCD was also evaluated. Methods—MVD and MCD were investigated in tumour specimens from 53 patients diagnosed with SCC of the oesophagus. Intratumoral microvessels were stained with anti-CD34 antibody and mast cells with toluidine blue before being measured by light microscopy. Results—Both MVD and MCD were associated with the depth of wall invasion, lymph node metastasis, and tumour progression (stage). A significant correlation was noted between MVD and MCD values (r = 0.72). The prognosis was significantly worse in patients with high MVD (≥ 92) and high MCD (≥ 18) values. Multivariate analysis indicated that MVD and stage were independent predictors of survival. Conclusions—These findings support the suggestion that MVD is a reliable prognostic marker in SCC of the oesophagus. Moreover, MCD may have a role in the angiogenesis of these tumours and might be responsible for their aggressive behaviour.</description><subject>Adult</subject><subject>Angiogenesis</subject><subject>Antibodies</subject><subject>Antigens, CD34 - analysis</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - blood supply</subject><subject>Carcinoma, Squamous Cell - immunology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Cell Count</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - blood supply</subject><subject>Esophageal Neoplasms - immunology</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagus</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>mast cell</subject><subject>Mast Cells - pathology</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Metastasis</subject><subject>Microcirculation</subject><subject>microvessel density</subject><subject>Middle Aged</subject><subject>Neovascularization</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>oesophagus</subject><subject>Physiological aspects</subject><subject>Prognosis</subject><subject>Squamous cell carcinoma</subject><subject>Surgery</subject><subject>Survival Analysis</subject><subject>Tumors</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kt1rFDEUxQdR7Fp99FUGRJ-cNTefMy-FslgVigrWCn0J2Uwym3UmmSYzRf97s3bpqojkIeTeX87NCacongJaAhD-eqvHJaNLwMuGonvFAqjAFQXK7xcLhDBUjaD8qHiU0hYhIALIw-IIQOAGA10U7cXGlGMMnQ9pcrqMpjc3ymtTBlsq37nQGW-SS_nQloNKU6lN36fS-TJdz2oIc_pVKbWK2vkwqN3NKasGk8K4Ud2cHhcPrOqTebLfj4svZ28uVu-q849v369OzyvNGJ0qiq21jTWca1Qjxlid367XltGGqTVQ1tTaWsF4yzhZa123NQbCaIs4QWthyXFxcqs7zuvBtNr4KapejtENKv6QQTn5Z8e7jezCjQRBgBCeBV7uBWK4nk2a5ODSzp3yJhuVAhNgtWgy-PwvcBvm6LM5iTmmGImG7-Re3VKd6o103oY8Ve8-NA8P3liXy6c1YFZTLDJe_QPPqzWD0__hdQwpRWPvnAKSu3DIHA7JqAQsczgy_-z37znQ-zRk4MUeUEmr3sYcBJcOHAWMCaoPg12azPe7vorfJBdEMPnhciU_oyt89vXTpbwiPwFsN9JK</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Elpek, G Ö</creator><creator>Gelen, T</creator><creator>Aksoy, N H</creator><creator>Erdoğan, A</creator><creator>Dertsiz, L</creator><creator>Demircan, A</creator><creator>Keleş, N</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ</general><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20011201</creationdate><title>The prognostic relevance of angiogenesis and mast cells in squamous cell carcinoma of the oesophagus</title><author>Elpek, G Ö ; Gelen, T ; Aksoy, N H ; Erdoğan, A ; Dertsiz, L ; Demircan, A ; Keleş, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-42fff9fe66c0805558974cbf5495ab14598cff756d563bcc8d821354d0630b7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Angiogenesis</topic><topic>Antibodies</topic><topic>Antigens, CD34 - analysis</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - blood supply</topic><topic>Carcinoma, Squamous Cell - immunology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Cell Count</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - blood supply</topic><topic>Esophageal Neoplasms - immunology</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagus</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>mast cell</topic><topic>Mast Cells - pathology</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Metastasis</topic><topic>Microcirculation</topic><topic>microvessel density</topic><topic>Middle Aged</topic><topic>Neovascularization</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>oesophagus</topic><topic>Physiological aspects</topic><topic>Prognosis</topic><topic>Squamous cell carcinoma</topic><topic>Surgery</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elpek, G Ö</creatorcontrib><creatorcontrib>Gelen, T</creatorcontrib><creatorcontrib>Aksoy, N H</creatorcontrib><creatorcontrib>Erdoğan, A</creatorcontrib><creatorcontrib>Dertsiz, L</creatorcontrib><creatorcontrib>Demircan, A</creatorcontrib><creatorcontrib>Keleş, N</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elpek, G Ö</au><au>Gelen, T</au><au>Aksoy, N H</au><au>Erdoğan, A</au><au>Dertsiz, L</au><au>Demircan, A</au><au>Keleş, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prognostic relevance of angiogenesis and mast cells in squamous cell carcinoma of the oesophagus</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>54</volume><issue>12</issue><spage>940</spage><epage>944</epage><pages>940-944</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><coden>JCPAAK</coden><abstract>Aims—Angiogenesis, an important prognostic factor in several tumours, is a complex event mediated by angiogenic factors released from cancer cells and host immune cells. Among the host immune cells, a role has been implicated for mast cells in tumour progression via promoting angiogenesis. Data have been recorded that indicate a correlation between intratumoral neovascularisation, as assessed by microvessel density (MVD), and prognosis in squamous cell carcinoma (SCC) of the oesophagus. However, a correlation between mast cell density (MCD) and either prognosis or angiogenesis has not been delineated yet in this disease. The aim of this study was to investigate the prognostic value of MVD and MCD in SCC of the oesophagus. The correlation between MVD and MCD was also evaluated. Methods—MVD and MCD were investigated in tumour specimens from 53 patients diagnosed with SCC of the oesophagus. Intratumoral microvessels were stained with anti-CD34 antibody and mast cells with toluidine blue before being measured by light microscopy. Results—Both MVD and MCD were associated with the depth of wall invasion, lymph node metastasis, and tumour progression (stage). A significant correlation was noted between MVD and MCD values (r = 0.72). The prognosis was significantly worse in patients with high MVD (≥ 92) and high MCD (≥ 18) values. Multivariate analysis indicated that MVD and stage were independent predictors of survival. Conclusions—These findings support the suggestion that MVD is a reliable prognostic marker in SCC of the oesophagus. Moreover, MCD may have a role in the angiogenesis of these tumours and might be responsible for their aggressive behaviour.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>11729214</pmid><doi>10.1136/jcp.54.12.940</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Angiogenesis Antibodies Antigens, CD34 - analysis Biological and medical sciences Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - surgery Cell Count Esophageal cancer Esophageal Neoplasms - blood supply Esophageal Neoplasms - immunology Esophageal Neoplasms - surgery Esophagus Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Humans Lymphatic system Male mast cell Mast Cells - pathology Medical prognosis Medical sciences Metastasis Microcirculation microvessel density Middle Aged Neovascularization Neovascularization, Pathologic - pathology oesophagus Physiological aspects Prognosis Squamous cell carcinoma Surgery Survival Analysis Tumors |
| title | The prognostic relevance of angiogenesis and mast cells in squamous cell carcinoma of the oesophagus |
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