The expression of antiapoptotic proteins Bcl-2, Bcl-XL, and Mcl-1 in benign, dysplastic, and malignant biliary epithelium

Aim—Cholangiocarcinoma can be cured by surgery, but only in a minority of cases. The activation of apoptosis is a major mode of action of chemotherapy and radiotherapy, which have limited benefit in the treatment of cholangiocarcinoma. The antiapoptotic members of the Bcl-2 protein family (Bcl-2, Bc...

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Veröffentlicht in:	Journal of clinical pathology 2001-12, Vol.54 (12), p.927-932
Hauptverfasser:	Okaro, A C, Deery, A R, Hutchins, R R, Davidson, B R
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bcl-2 Bcl-XL Bile ducts Biological and medical sciences Cellular biology Chemotherapy Cholangiocarcinoma Gastroenterology. Liver. Pancreas. Abdomen Liver. Biliary tract. Portal circulation. Exocrine pancreas Lymphatic system Mcl-2 Medical prognosis Medical sciences Microscopy Permeability Polyclonal antibodies Proteins Radiation therapy Stains & staining Surgery Tumors
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