Coronary heart disease after prenatal exposure to the Dutch famine, 1944–45
OBJECTIVE To assess the effect of prenatal exposure to maternal malnutrition on coronary heart disease in people born around the time of the Dutch famine, 1944–45. DESIGN Historical cohort study. SETTING Community study. PATIENTS Singletons born alive between November 1943 and February 1947 for whom...
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| Veröffentlicht in: | British heart journal 2000-12, Vol.84 (6), p.595-598 |
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| creator | Roseboom, T J van der Meulen, J H P Osmond, C Barker, D J P Ravelli, A C J Schroeder-Tanka, J M van Montfrans, G A Michels, R P J Bleker, O P |
| description | OBJECTIVE To assess the effect of prenatal exposure to maternal malnutrition on coronary heart disease in people born around the time of the Dutch famine, 1944–45. DESIGN Historical cohort study. SETTING Community study. PATIENTS Singletons born alive between November 1943 and February 1947 for whom detailed birth records were available. DESIGN The prevalence of coronary heart disease was compared between those exposed to famine in late gestation (n = 120), in mid-gestation (n = 108), or in early gestation (n = 68), and those born in the year before the famine or those conceived in the year after the famine (non-exposed subjects, n = 440). MAIN OUTCOME MEASURES Prevalence of coronary heart disease, defined as the presence of angina pectoris according to the Rose questionnaire, Q waves on the ECG, or a history of coronary revascularisation. RESULTS The prevalence of coronary heart disease was higher in those exposed in early gestation than in non-exposed people (8.8% v 3.2%; odds ratio adjusted for sex 3.0, 95% confidence interval (CI) 1.1 to 8.1). The prevalence was not increased in those exposed in mid gestation (0.9%) or late gestation (2.5%). People with coronary heart disease tended to have lower birth weights (3215 g v 3352 g, p = 0.13), and smaller head circumferences at birth (32.2 cmv 32.8 cm, p = 0.05), but the effect of exposure to famine in early gestation was independent of birth weight (adjusted odds ratio 3.2, 95% CI 1.2 to 8.8). CONCLUSIONS Although the numbers are very small, this is the first evidence suggesting that maternal malnutrition during early gestation contributes to the occurrence of coronary heart disease in the offspring. |
| doi_str_mv | 10.1136/heart.84.6.595 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1729504</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72420141</sourcerecordid><originalsourceid>FETCH-LOGICAL-b580t-33447aecd809b1bc8820aed77259d7513128e02b008b9eb111f9e362bf2dc1193</originalsourceid><addsrcrecordid>eNqFkcGKFDEQhoMo7u7o1aM0CMKCPaY6SSe5LMioozCuCLp6C-nuaqfH7s6YpGW9-Q6-oU9idmcYVy-eEqiv_qq_fkIeAJ0DsPLpGq2Pc8Xn5VxocYscAy9VXlD4dDv9mRB5SZk8IichbCilXKvyLjkCoIpJxo_Jm4XzbrT-e3atlDVdQBsws21En209jjbaPsPLrQuTxyy6LK4xez7Fep21duhGfJKB5vzXj59c3CN3WtsHvL9_Z-TDyxfvF6_y1dvl68WzVV4JRWPOGOfSYt0oqiuoaqUKarGRshC6kQIYFAppUVGqKo0VALQaWVlUbdHUAJrNyNlOdztVAzY1jtHb3mx9NyQrxtnO_F0Zu7X57L4ZkIUWlCeBx3sB775OGKIZulBj39sR3RSMLHi6IYcEPvoH3LjJj8lc0lJUCc3SIWdkvqNq70Lw2B5WAWqucjLX1zWKm9KknFLDw5sG_uD7YG7MtaG2fevtWHfhwCmgQl3NzXdUFyJeHqrWfzGlZFKY84uF0auLd-d0uTQfE3-646th878VfwM4oLgl</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780859337</pqid></control><display><type>article</type><title>Coronary heart disease after prenatal exposure to the Dutch famine, 1944–45</title><source>MEDLINE</source><source>PubMed Central (PMC)</source><source>EZB Electronic Journals Library</source><creator>Roseboom, T J ; van der Meulen, J H P ; Osmond, C ; Barker, D J P ; Ravelli, A C J ; Schroeder-Tanka, J M ; van Montfrans, G A ; Michels, R P J ; Bleker, O P</creator><creatorcontrib>Roseboom, T J ; van der Meulen, J H P ; Osmond, C ; Barker, D J P ; Ravelli, A C J ; Schroeder-Tanka, J M ; van Montfrans, G A ; Michels, R P J ; Bleker, O P</creatorcontrib><description>OBJECTIVE To assess the effect of prenatal exposure to maternal malnutrition on coronary heart disease in people born around the time of the Dutch famine, 1944–45. DESIGN Historical cohort study. SETTING Community study. PATIENTS Singletons born alive between November 1943 and February 1947 for whom detailed birth records were available. DESIGN The prevalence of coronary heart disease was compared between those exposed to famine in late gestation (n = 120), in mid-gestation (n = 108), or in early gestation (n = 68), and those born in the year before the famine or those conceived in the year after the famine (non-exposed subjects, n = 440). MAIN OUTCOME MEASURES Prevalence of coronary heart disease, defined as the presence of angina pectoris according to the Rose questionnaire, Q waves on the ECG, or a history of coronary revascularisation. RESULTS The prevalence of coronary heart disease was higher in those exposed in early gestation than in non-exposed people (8.8% v 3.2%; odds ratio adjusted for sex 3.0, 95% confidence interval (CI) 1.1 to 8.1). The prevalence was not increased in those exposed in mid gestation (0.9%) or late gestation (2.5%). People with coronary heart disease tended to have lower birth weights (3215 g v 3352 g, p = 0.13), and smaller head circumferences at birth (32.2 cmv 32.8 cm, p = 0.05), but the effect of exposure to famine in early gestation was independent of birth weight (adjusted odds ratio 3.2, 95% CI 1.2 to 8.8). CONCLUSIONS Although the numbers are very small, this is the first evidence suggesting that maternal malnutrition during early gestation contributes to the occurrence of coronary heart disease in the offspring.</description><identifier>ISSN: 1355-6037</identifier><identifier>ISSN: 0007-0769</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heart.84.6.595</identifier><identifier>PMID: 11083734</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Angina pectoris ; Biological and medical sciences ; Birth Weight ; Cardiology. Vascular system ; Cardiovascular disease ; Cardiovascular Medicine ; Cephalometry ; Cohort Studies ; Coronary Disease - embryology ; Coronary Disease - epidemiology ; Coronary heart disease ; Famine ; Female ; fetal origins hypothesis ; Gestational Age ; Health risk assessment ; Heart ; Humans ; Infant, Newborn ; Male ; maternal malnutrition ; Medical sciences ; Middle Aged ; Mortality ; Netherlands - epidemiology ; Placental Insufficiency - complications ; Pregnancy ; Pregnancy Complications ; Prenatal exposure ; Prenatal Exposure Delayed Effects ; Prevalence ; Risk Factors ; Starvation - complications ; Womens health</subject><ispartof>British heart journal, 2000-12, Vol.84 (6), p.595-598</ispartof><rights>British Cardiac Society</rights><rights>2001 INIST-CNRS</rights><rights>Copyright: 2000 British Cardiac Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b580t-33447aecd809b1bc8820aed77259d7513128e02b008b9eb111f9e362bf2dc1193</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1729504/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1729504/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=810587$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11083734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roseboom, T J</creatorcontrib><creatorcontrib>van der Meulen, J H P</creatorcontrib><creatorcontrib>Osmond, C</creatorcontrib><creatorcontrib>Barker, D J P</creatorcontrib><creatorcontrib>Ravelli, A C J</creatorcontrib><creatorcontrib>Schroeder-Tanka, J M</creatorcontrib><creatorcontrib>van Montfrans, G A</creatorcontrib><creatorcontrib>Michels, R P J</creatorcontrib><creatorcontrib>Bleker, O P</creatorcontrib><title>Coronary heart disease after prenatal exposure to the Dutch famine, 1944–45</title><title>British heart journal</title><addtitle>Heart</addtitle><description>OBJECTIVE To assess the effect of prenatal exposure to maternal malnutrition on coronary heart disease in people born around the time of the Dutch famine, 1944–45. DESIGN Historical cohort study. SETTING Community study. PATIENTS Singletons born alive between November 1943 and February 1947 for whom detailed birth records were available. DESIGN The prevalence of coronary heart disease was compared between those exposed to famine in late gestation (n = 120), in mid-gestation (n = 108), or in early gestation (n = 68), and those born in the year before the famine or those conceived in the year after the famine (non-exposed subjects, n = 440). MAIN OUTCOME MEASURES Prevalence of coronary heart disease, defined as the presence of angina pectoris according to the Rose questionnaire, Q waves on the ECG, or a history of coronary revascularisation. RESULTS The prevalence of coronary heart disease was higher in those exposed in early gestation than in non-exposed people (8.8% v 3.2%; odds ratio adjusted for sex 3.0, 95% confidence interval (CI) 1.1 to 8.1). The prevalence was not increased in those exposed in mid gestation (0.9%) or late gestation (2.5%). People with coronary heart disease tended to have lower birth weights (3215 g v 3352 g, p = 0.13), and smaller head circumferences at birth (32.2 cmv 32.8 cm, p = 0.05), but the effect of exposure to famine in early gestation was independent of birth weight (adjusted odds ratio 3.2, 95% CI 1.2 to 8.8). CONCLUSIONS Although the numbers are very small, this is the first evidence suggesting that maternal malnutrition during early gestation contributes to the occurrence of coronary heart disease in the offspring.</description><subject>Angina pectoris</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Medicine</subject><subject>Cephalometry</subject><subject>Cohort Studies</subject><subject>Coronary Disease - embryology</subject><subject>Coronary Disease - epidemiology</subject><subject>Coronary heart disease</subject><subject>Famine</subject><subject>Female</subject><subject>fetal origins hypothesis</subject><subject>Gestational Age</subject><subject>Health risk assessment</subject><subject>Heart</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>maternal malnutrition</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Netherlands - epidemiology</subject><subject>Placental Insufficiency - complications</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><subject>Prenatal exposure</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Starvation - complications</subject><subject>Womens health</subject><issn>1355-6037</issn><issn>0007-0769</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkcGKFDEQhoMo7u7o1aM0CMKCPaY6SSe5LMioozCuCLp6C-nuaqfH7s6YpGW9-Q6-oU9idmcYVy-eEqiv_qq_fkIeAJ0DsPLpGq2Pc8Xn5VxocYscAy9VXlD4dDv9mRB5SZk8IichbCilXKvyLjkCoIpJxo_Jm4XzbrT-e3atlDVdQBsws21En209jjbaPsPLrQuTxyy6LK4xez7Fep21duhGfJKB5vzXj59c3CN3WtsHvL9_Z-TDyxfvF6_y1dvl68WzVV4JRWPOGOfSYt0oqiuoaqUKarGRshC6kQIYFAppUVGqKo0VALQaWVlUbdHUAJrNyNlOdztVAzY1jtHb3mx9NyQrxtnO_F0Zu7X57L4ZkIUWlCeBx3sB775OGKIZulBj39sR3RSMLHi6IYcEPvoH3LjJj8lc0lJUCc3SIWdkvqNq70Lw2B5WAWqucjLX1zWKm9KknFLDw5sG_uD7YG7MtaG2fevtWHfhwCmgQl3NzXdUFyJeHqrWfzGlZFKY84uF0auLd-d0uTQfE3-646th878VfwM4oLgl</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>Roseboom, T J</creator><creator>van der Meulen, J H P</creator><creator>Osmond, C</creator><creator>Barker, D J P</creator><creator>Ravelli, A C J</creator><creator>Schroeder-Tanka, J M</creator><creator>van Montfrans, G A</creator><creator>Michels, R P J</creator><creator>Bleker, O P</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20001201</creationdate><title>Coronary heart disease after prenatal exposure to the Dutch famine, 1944–45</title><author>Roseboom, T J ; van der Meulen, J H P ; Osmond, C ; Barker, D J P ; Ravelli, A C J ; Schroeder-Tanka, J M ; van Montfrans, G A ; Michels, R P J ; Bleker, O P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b580t-33447aecd809b1bc8820aed77259d7513128e02b008b9eb111f9e362bf2dc1193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Angina pectoris</topic><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Medicine</topic><topic>Cephalometry</topic><topic>Cohort Studies</topic><topic>Coronary Disease - embryology</topic><topic>Coronary Disease - epidemiology</topic><topic>Coronary heart disease</topic><topic>Famine</topic><topic>Female</topic><topic>fetal origins hypothesis</topic><topic>Gestational Age</topic><topic>Health risk assessment</topic><topic>Heart</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>maternal malnutrition</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Netherlands - epidemiology</topic><topic>Placental Insufficiency - complications</topic><topic>Pregnancy</topic><topic>Pregnancy Complications</topic><topic>Prenatal exposure</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Starvation - complications</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roseboom, T J</creatorcontrib><creatorcontrib>van der Meulen, J H P</creatorcontrib><creatorcontrib>Osmond, C</creatorcontrib><creatorcontrib>Barker, D J P</creatorcontrib><creatorcontrib>Ravelli, A C J</creatorcontrib><creatorcontrib>Schroeder-Tanka, J M</creatorcontrib><creatorcontrib>van Montfrans, G A</creatorcontrib><creatorcontrib>Michels, R P J</creatorcontrib><creatorcontrib>Bleker, O P</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roseboom, T J</au><au>van der Meulen, J H P</au><au>Osmond, C</au><au>Barker, D J P</au><au>Ravelli, A C J</au><au>Schroeder-Tanka, J M</au><au>van Montfrans, G A</au><au>Michels, R P J</au><au>Bleker, O P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronary heart disease after prenatal exposure to the Dutch famine, 1944–45</atitle><jtitle>British heart journal</jtitle><addtitle>Heart</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>84</volume><issue>6</issue><spage>595</spage><epage>598</epage><pages>595-598</pages><issn>1355-6037</issn><issn>0007-0769</issn><eissn>1468-201X</eissn><abstract>OBJECTIVE To assess the effect of prenatal exposure to maternal malnutrition on coronary heart disease in people born around the time of the Dutch famine, 1944–45. DESIGN Historical cohort study. SETTING Community study. PATIENTS Singletons born alive between November 1943 and February 1947 for whom detailed birth records were available. DESIGN The prevalence of coronary heart disease was compared between those exposed to famine in late gestation (n = 120), in mid-gestation (n = 108), or in early gestation (n = 68), and those born in the year before the famine or those conceived in the year after the famine (non-exposed subjects, n = 440). MAIN OUTCOME MEASURES Prevalence of coronary heart disease, defined as the presence of angina pectoris according to the Rose questionnaire, Q waves on the ECG, or a history of coronary revascularisation. RESULTS The prevalence of coronary heart disease was higher in those exposed in early gestation than in non-exposed people (8.8% v 3.2%; odds ratio adjusted for sex 3.0, 95% confidence interval (CI) 1.1 to 8.1). The prevalence was not increased in those exposed in mid gestation (0.9%) or late gestation (2.5%). People with coronary heart disease tended to have lower birth weights (3215 g v 3352 g, p = 0.13), and smaller head circumferences at birth (32.2 cmv 32.8 cm, p = 0.05), but the effect of exposure to famine in early gestation was independent of birth weight (adjusted odds ratio 3.2, 95% CI 1.2 to 8.8). CONCLUSIONS Although the numbers are very small, this is the first evidence suggesting that maternal malnutrition during early gestation contributes to the occurrence of coronary heart disease in the offspring.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>11083734</pmid><doi>10.1136/heart.84.6.595</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Angina pectoris Biological and medical sciences Birth Weight Cardiology. Vascular system Cardiovascular disease Cardiovascular Medicine Cephalometry Cohort Studies Coronary Disease - embryology Coronary Disease - epidemiology Coronary heart disease Famine Female fetal origins hypothesis Gestational Age Health risk assessment Heart Humans Infant, Newborn Male maternal malnutrition Medical sciences Middle Aged Mortality Netherlands - epidemiology Placental Insufficiency - complications Pregnancy Pregnancy Complications Prenatal exposure Prenatal Exposure Delayed Effects Prevalence Risk Factors Starvation - complications Womens health |
| title | Coronary heart disease after prenatal exposure to the Dutch famine, 1944–45 |
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