Influence of hypertension, left ventricular hypertrophy, and left ventricular systolic dysfunction on plasma N terminal proBNP
OBJECTIVES To examine the relation between plasma concentration of the N terminal of the precursor of brain natriuretic peptide (NT proBNP), left ventricular hypertrophy (LVH), and left ventricular systolic dysfunction (LVSD) in patients with a history of hypertension. DESIGN Prospective study. SETT...
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| Veröffentlicht in: | British heart journal 2000-03, Vol.83 (3), p.278-282 |
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| creator | Talwar, S Siebenhofer, A Williams, B Ng, L |
| description | OBJECTIVES To examine the relation between plasma concentration of the N terminal of the precursor of brain natriuretic peptide (NT proBNP), left ventricular hypertrophy (LVH), and left ventricular systolic dysfunction (LVSD) in patients with a history of hypertension. DESIGN Prospective study. SETTING Teaching hospital based study. PATIENTS NT proBNP concentrations were determined in five groups of individuals. Group 1: 15 echocardiographic normal controls; group 2: 22 patients with hypertension, normal left ventricular systolic function, and no LVH; group 3: 24 patients with hypertension, normal left ventricular systolic function, and LVH; group 4: 13 patients with history of hypertension, no history of ischaemic heart disease, and left ventricular wall motion index (WMI) between 1.9–1.3; and group 5:17 patients with a history of hypertension, no history of ischaemic heart disease, and WMI |
| doi_str_mv | 10.1136/heart.83.3.278 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1729338</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4021394561</sourcerecordid><originalsourceid>FETCH-LOGICAL-b581t-16e8700efe674a9aff96028d420cd1e329393236d5e939dfc6fa17af9b3e29b53</originalsourceid><addsrcrecordid>eNqFkdFr1TAYxYs43Jy--igFRRDWmjRtkr4IetE52K4KOnwLafrF22ua1KQd9sW_fbn2Mqc-CIF8cH45nC8nSR5hlGNM6IsNSD_mnOQkLxi_kxzhkvKsQPjL3TiTqsooIuwwuR_CFiFU1pzeSw4xooyVqDpKfp5ZbSawClKn0808gB_Bhs7Zk9SAHtMrsKPv1GSk38veDZv5JJW2_ZcIcxid6VTazkFPVo3RKI1nMDL0Ml2nI_i-s9Kkg3ev1x8eJAdamgAP9_dx8vntm0-rd9n5-9Oz1avzrKk4HjNMgTOEQANlpayl1jVFBW_LAqkWAylqUpOC0LaCOLVaUS0xk7puCBR1U5Hj5OXiO0xND63aRZZGDL7rpZ-Fk534U7HdRnx1VwKz6E14NHi2N_Du-wRhFH0XFBgjLbgpCIbq3fcWEXzyF7h1k48bh-jFEeN1XdFI5QulvAvBg76JgpHYFSt-FSs4EUTEYuODx7cXuIUvTUbg6R6QQUmjvbSqC7-5gjFc4ohlC9aFEX7cyNJ_E5QRVon15Urwi4vL1ceSiNPIP1_4pt_-L-M1toXMhQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780789956</pqid></control><display><type>article</type><title>Influence of hypertension, left ventricular hypertrophy, and left ventricular systolic dysfunction on plasma N terminal proBNP</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Talwar, S ; Siebenhofer, A ; Williams, B ; Ng, L</creator><creatorcontrib>Talwar, S ; Siebenhofer, A ; Williams, B ; Ng, L</creatorcontrib><description>OBJECTIVES To examine the relation between plasma concentration of the N terminal of the precursor of brain natriuretic peptide (NT proBNP), left ventricular hypertrophy (LVH), and left ventricular systolic dysfunction (LVSD) in patients with a history of hypertension. DESIGN Prospective study. SETTING Teaching hospital based study. PATIENTS NT proBNP concentrations were determined in five groups of individuals. Group 1: 15 echocardiographic normal controls; group 2: 22 patients with hypertension, normal left ventricular systolic function, and no LVH; group 3: 24 patients with hypertension, normal left ventricular systolic function, and LVH; group 4: 13 patients with history of hypertension, no history of ischaemic heart disease, and left ventricular wall motion index (WMI) between 1.9–1.3; and group 5:17 patients with a history of hypertension, no history of ischaemic heart disease, and WMI < 1.2. RESULTS Median (range) NT proBNP concentrations (in fmol/ml) for groups 1–5, respectively, were: 129.4 (53.6–159.7), 147.4 (54.3–730.5), 137.1 (35.8–403.9), 356.7 (124.4–934.4), and 493.5 (248.9–909). Mean log NT proBNP differed among all five groups (p < 0.0001), and between groups 4 and 5 versus groups 1–3 (p < 0.0001), and group 4 versus group 5 (p = 0.02) only. CONCLUSIONS The results suggest that the presence of hypertension with or without LVH (and normal left ventricular systolic function) does not affect NT proBNP concentrations. Moreover, there is a significant rise in NT proBNP only when LVSD develops in hypertension. Thus, NT proBNP remains a useful diagnostic aid for LVSD, even in hypertensive patients.</description><identifier>ISSN: 1355-6037</identifier><identifier>ISSN: 0007-0769</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heart.83.3.278</identifier><identifier>PMID: 10677405</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood pressure ; brain natriuretic peptide ; Cardiology. Vascular system ; Cardiovascular disease ; Cardiovascular Medicine ; chemiluminescence ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Cross-Sectional Studies ; Female ; Heart attacks ; Heart failure ; Humans ; Hypertension ; Hypertension - blood ; Hypertension - physiopathology ; Hypertrophy, Left Ventricular - blood ; Hypertrophy, Left Ventricular - physiopathology ; left ventricular hypertrophy ; left ventricular systolic dysfunction ; Male ; Medical sciences ; Middle Aged ; Natriuretic Peptide, Brain ; Nerve Tissue Proteins - blood ; Peptide Fragments - blood ; Peptides ; Plasma ; Prospective Studies ; Regression Analysis ; Substance abuse treatment ; Ventricular Dysfunction, Left - blood ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>British heart journal, 2000-03, Vol.83 (3), p.278-282</ispartof><rights>British Cardiac Society</rights><rights>2000 INIST-CNRS</rights><rights>Copyright: 2000 British Cardiac Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b581t-16e8700efe674a9aff96028d420cd1e329393236d5e939dfc6fa17af9b3e29b53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1729338/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1729338/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1277141$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10677405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Talwar, S</creatorcontrib><creatorcontrib>Siebenhofer, A</creatorcontrib><creatorcontrib>Williams, B</creatorcontrib><creatorcontrib>Ng, L</creatorcontrib><title>Influence of hypertension, left ventricular hypertrophy, and left ventricular systolic dysfunction on plasma N terminal proBNP</title><title>British heart journal</title><addtitle>Heart</addtitle><description>OBJECTIVES To examine the relation between plasma concentration of the N terminal of the precursor of brain natriuretic peptide (NT proBNP), left ventricular hypertrophy (LVH), and left ventricular systolic dysfunction (LVSD) in patients with a history of hypertension. DESIGN Prospective study. SETTING Teaching hospital based study. PATIENTS NT proBNP concentrations were determined in five groups of individuals. Group 1: 15 echocardiographic normal controls; group 2: 22 patients with hypertension, normal left ventricular systolic function, and no LVH; group 3: 24 patients with hypertension, normal left ventricular systolic function, and LVH; group 4: 13 patients with history of hypertension, no history of ischaemic heart disease, and left ventricular wall motion index (WMI) between 1.9–1.3; and group 5:17 patients with a history of hypertension, no history of ischaemic heart disease, and WMI < 1.2. RESULTS Median (range) NT proBNP concentrations (in fmol/ml) for groups 1–5, respectively, were: 129.4 (53.6–159.7), 147.4 (54.3–730.5), 137.1 (35.8–403.9), 356.7 (124.4–934.4), and 493.5 (248.9–909). Mean log NT proBNP differed among all five groups (p < 0.0001), and between groups 4 and 5 versus groups 1–3 (p < 0.0001), and group 4 versus group 5 (p = 0.02) only. CONCLUSIONS The results suggest that the presence of hypertension with or without LVH (and normal left ventricular systolic function) does not affect NT proBNP concentrations. Moreover, there is a significant rise in NT proBNP only when LVSD develops in hypertension. Thus, NT proBNP remains a useful diagnostic aid for LVSD, even in hypertensive patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood pressure</subject><subject>brain natriuretic peptide</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Medicine</subject><subject>chemiluminescence</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - blood</subject><subject>Hypertension - physiopathology</subject><subject>Hypertrophy, Left Ventricular - blood</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>left ventricular hypertrophy</subject><subject>left ventricular systolic dysfunction</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain</subject><subject>Nerve Tissue Proteins - blood</subject><subject>Peptide Fragments - blood</subject><subject>Peptides</subject><subject>Plasma</subject><subject>Prospective Studies</subject><subject>Regression Analysis</subject><subject>Substance abuse treatment</subject><subject>Ventricular Dysfunction, Left - blood</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>1355-6037</issn><issn>0007-0769</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkdFr1TAYxYs43Jy--igFRRDWmjRtkr4IetE52K4KOnwLafrF22ua1KQd9sW_fbn2Mqc-CIF8cH45nC8nSR5hlGNM6IsNSD_mnOQkLxi_kxzhkvKsQPjL3TiTqsooIuwwuR_CFiFU1pzeSw4xooyVqDpKfp5ZbSawClKn0808gB_Bhs7Zk9SAHtMrsKPv1GSk38veDZv5JJW2_ZcIcxid6VTazkFPVo3RKI1nMDL0Ml2nI_i-s9Kkg3ev1x8eJAdamgAP9_dx8vntm0-rd9n5-9Oz1avzrKk4HjNMgTOEQANlpayl1jVFBW_LAqkWAylqUpOC0LaCOLVaUS0xk7puCBR1U5Hj5OXiO0xND63aRZZGDL7rpZ-Fk534U7HdRnx1VwKz6E14NHi2N_Du-wRhFH0XFBgjLbgpCIbq3fcWEXzyF7h1k48bh-jFEeN1XdFI5QulvAvBg76JgpHYFSt-FSs4EUTEYuODx7cXuIUvTUbg6R6QQUmjvbSqC7-5gjFc4ohlC9aFEX7cyNJ_E5QRVon15Urwi4vL1ceSiNPIP1_4pt_-L-M1toXMhQ</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>Talwar, S</creator><creator>Siebenhofer, A</creator><creator>Williams, B</creator><creator>Ng, L</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20000301</creationdate><title>Influence of hypertension, left ventricular hypertrophy, and left ventricular systolic dysfunction on plasma N terminal proBNP</title><author>Talwar, S ; Siebenhofer, A ; Williams, B ; Ng, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b581t-16e8700efe674a9aff96028d420cd1e329393236d5e939dfc6fa17af9b3e29b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood pressure</topic><topic>brain natriuretic peptide</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Medicine</topic><topic>chemiluminescence</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - blood</topic><topic>Hypertension - physiopathology</topic><topic>Hypertrophy, Left Ventricular - blood</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>left ventricular hypertrophy</topic><topic>left ventricular systolic dysfunction</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain</topic><topic>Nerve Tissue Proteins - blood</topic><topic>Peptide Fragments - blood</topic><topic>Peptides</topic><topic>Plasma</topic><topic>Prospective Studies</topic><topic>Regression Analysis</topic><topic>Substance abuse treatment</topic><topic>Ventricular Dysfunction, Left - blood</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Talwar, S</creatorcontrib><creatorcontrib>Siebenhofer, A</creatorcontrib><creatorcontrib>Williams, B</creatorcontrib><creatorcontrib>Ng, L</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Talwar, S</au><au>Siebenhofer, A</au><au>Williams, B</au><au>Ng, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of hypertension, left ventricular hypertrophy, and left ventricular systolic dysfunction on plasma N terminal proBNP</atitle><jtitle>British heart journal</jtitle><addtitle>Heart</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>83</volume><issue>3</issue><spage>278</spage><epage>282</epage><pages>278-282</pages><issn>1355-6037</issn><issn>0007-0769</issn><eissn>1468-201X</eissn><abstract>OBJECTIVES To examine the relation between plasma concentration of the N terminal of the precursor of brain natriuretic peptide (NT proBNP), left ventricular hypertrophy (LVH), and left ventricular systolic dysfunction (LVSD) in patients with a history of hypertension. DESIGN Prospective study. SETTING Teaching hospital based study. PATIENTS NT proBNP concentrations were determined in five groups of individuals. Group 1: 15 echocardiographic normal controls; group 2: 22 patients with hypertension, normal left ventricular systolic function, and no LVH; group 3: 24 patients with hypertension, normal left ventricular systolic function, and LVH; group 4: 13 patients with history of hypertension, no history of ischaemic heart disease, and left ventricular wall motion index (WMI) between 1.9–1.3; and group 5:17 patients with a history of hypertension, no history of ischaemic heart disease, and WMI < 1.2. RESULTS Median (range) NT proBNP concentrations (in fmol/ml) for groups 1–5, respectively, were: 129.4 (53.6–159.7), 147.4 (54.3–730.5), 137.1 (35.8–403.9), 356.7 (124.4–934.4), and 493.5 (248.9–909). Mean log NT proBNP differed among all five groups (p < 0.0001), and between groups 4 and 5 versus groups 1–3 (p < 0.0001), and group 4 versus group 5 (p = 0.02) only. CONCLUSIONS The results suggest that the presence of hypertension with or without LVH (and normal left ventricular systolic function) does not affect NT proBNP concentrations. Moreover, there is a significant rise in NT proBNP only when LVSD develops in hypertension. Thus, NT proBNP remains a useful diagnostic aid for LVSD, even in hypertensive patients.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>10677405</pmid><doi>10.1136/heart.83.3.278</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood pressure brain natriuretic peptide Cardiology. Vascular system Cardiovascular disease Cardiovascular Medicine chemiluminescence Clinical manifestations. Epidemiology. Investigative techniques. Etiology Cross-Sectional Studies Female Heart attacks Heart failure Humans Hypertension Hypertension - blood Hypertension - physiopathology Hypertrophy, Left Ventricular - blood Hypertrophy, Left Ventricular - physiopathology left ventricular hypertrophy left ventricular systolic dysfunction Male Medical sciences Middle Aged Natriuretic Peptide, Brain Nerve Tissue Proteins - blood Peptide Fragments - blood Peptides Plasma Prospective Studies Regression Analysis Substance abuse treatment Ventricular Dysfunction, Left - blood Ventricular Dysfunction, Left - physiopathology |
| title | Influence of hypertension, left ventricular hypertrophy, and left ventricular systolic dysfunction on plasma N terminal proBNP |
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