Effect of an α2 agonist (mivazerol) on limiting myocardial ischaemia in stable angina
A specific α2 agonist, mivazerol, known to be effective in reducing myocardial ischaemia when given intravenously immediately before an exercise tolerance test, produced a significant increase in exercise duration and time to the onset of angina when given orally over a two week period to 25 patient...
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| Veröffentlicht in: | Heart (British Cardiac Society) 1999-09, Vol.82 (3), p.383-385 |
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| container_end_page | 385 |
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| container_issue | 3 |
| container_start_page | 383 |
| container_title | Heart (British Cardiac Society) |
| container_volume | 82 |
| creator | Fox, K Dargie, H J de Bono, D P Oliver, M F Wülfert, E Kharkevitch, T |
| description | A specific α2 agonist, mivazerol, known to be effective in reducing myocardial ischaemia when given intravenously immediately before an exercise tolerance test, produced a significant increase in exercise duration and time to the onset of angina when given orally over a two week period to 25 patients with stable angina. A non-significant trend to reduction in electrocardiographic signs of ischaemia was also noted. The clinical relevance of this improvement now needs to be tested in larger numbers. |
| doi_str_mv | 10.1136/hrt.82.3.383 |
| format | Article |
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A non-significant trend to reduction in electrocardiographic signs of ischaemia was also noted. The clinical relevance of this improvement now needs to be tested in larger numbers.</description><subject>Antianginal agents. Coronary vasodilator agents</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>exercise tolerance test</subject><subject>Medical sciences</subject><subject>myocardial ischaemia</subject><subject>Pharmacology. 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| identifier | ISSN: 1355-6037 |
| ispartof | Heart (British Cardiac Society), 1999-09, Vol.82 (3), p.383-385 |
| issn | 1355-6037 1468-201X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1729187 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Antianginal agents. Coronary vasodilator agents Biological and medical sciences Cardiovascular system exercise tolerance test Medical sciences myocardial ischaemia Pharmacology. Drug treatments Preliminary Report stable angina sympathetic activity α2 agonist |
| title | Effect of an α2 agonist (mivazerol) on limiting myocardial ischaemia in stable angina |
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