Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis

Luminal nitric oxide (NO) is greatly increased in the colon of patients with collagenous and ulcerative colitis. To define the source and consequence of enhanced NO production we have studied expression of NO synthase (NOS) isoforms and nitrotyrosine in mucosal biopsies from these patients. In addit...

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Veröffentlicht in:	Gut 2001-09, Vol.49 (3), p.387-394
Hauptverfasser:	PERNER, A, ANDRESEN, L, NORMARK, M, FISCHER-HANSEN, B, SØRENSEN, S, EUGEN-OLSEN, J, RASK-MADSEN, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Arginine - physiology Biological and medical sciences Biopsy Blotting, Western Body Fluids - metabolism Case-Control Studies Cellular control mechanisms Colitis, Ulcerative - metabolism Colon Confidence Intervals Digestive system Endoscopy Enzymes Female Histopathology Humans Inflammation Inflammatory bowel disease Intestinal Absorption - physiology Investigative techniques, diagnostic techniques (general aspects) Laboratories Male Medical sciences Middle Aged Neutrophils Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type I Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Nitrogen dioxide omega-N-Methylarginine - physiology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Patients Physiological aspects Rodents Scholarships & fellowships Statistics, Nonparametric Tyrosine - analogs & derivatives Tyrosine - metabolism Ulcerative colitis Up-Regulation
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