Colonic crypt cell proliferation state assessed by whole crypt microdissection in sporadic neoplasia and familial adenomatous polyposis

BACKGROUND It has yet to be established whether proliferative activity in the macroscopically normal colonic mucosa is causally correlated with neoplastic risk. Measurement of proliferative activity in human subjects is of necessity usually undertaken using indirect methods with inherent limitations...

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Veröffentlicht in:	Gut 2001-01, Vol.48 (1), p.41-46
Hauptverfasser:	Mills, S J, Mathers, J C, Chapman, P D, Burn, J, Gunn, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - pathology Adenomatous Polyposis Coli - pathology Adult Aged Analysis of Variance Apoptosis Biological and medical sciences Biopsy Carcinoma - pathology Case-Control Studies Causes of Cell growth Cell proliferation Colon - pathology colonic crypt Colonic Neoplasms - pathology Colorectal cancer Digestive system Dissection Ethanol familial adenomatous polyposis Female Human subjects Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical research Medical sciences Methods Middle Aged Mitotic Index Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Physiological aspects Polyposis, Familial Rectum - pathology Reproducibility of Results Studies Surveillance Tumors
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