On the protective mechanisms of nitric oxide in acute pancreatitis

Background—Ectopic protease activation, microcirculatory changes, and leucocyte activation are the main events in the pathogenesis of acute pancreatitis. Nitric oxide (NO) is known to be a key mediator in the normal and inflamed pancreas. Aims—To investigate the targets on which NO exerts its effect...

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Veröffentlicht in:	Gut 1998-09, Vol.43 (3), p.401-407
Hauptverfasser:	Werner, J, Castillo, C Fernández-del, Rivera, J A, Kollias, N, Lewandrowski, K B, Rattner, D W, Warshaw, A L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease acute pancreatitis Animals Arginine - therapeutic use Biological and medical sciences Blood Cells, Cultured Ceruletide Endothelium Enzyme Inhibitors - pharmacology Experiments Gastroenterology. Liver. Pancreas. Abdomen Laboratory animals leucocytes Leukocytes Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences microcirculation NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - physiology Nitric Oxide Donors - therapeutic use Nitric Oxide Synthase - antagonists & inhibitors Nitroprusside - therapeutic use Oligopeptides - metabolism Other diseases. Semiology Pancreas Pancreas - drug effects Pancreas - metabolism Pancreas - pathology pancreatic secretion Pancreatitis - metabolism Pancreatitis - pathology Pancreatitis - prevention & control Pathogenesis Rats Rats, Sprague-Dawley Rats, Wistar Rodents Spectrum analysis Vasodilator Agents - therapeutic use
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