Cytochrome P4502E1 is present in rat pancreas and is induced by chronic ethanol administration
Background—The mechanisms responsible for the initiation of alcoholic pancreatitis remain elusive. However, there is an increasing body of evidence that reactive oxygen species play a role in both acute and chronic pancreatitis. In the liver, cytochrome P4502E1 (CYP2E1, the inducible ethanol metabol...
Gespeichert in:
| Veröffentlicht in: | Gut 1998-03, Vol.42 (3), p.426-430 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 430 |
|---|---|
| container_issue | 3 |
| container_start_page | 426 |
| container_title | Gut |
| container_volume | 42 |
| creator | Norton, I D Apte, M V Haber, P S McCaughan, G W Pirola, R C Wilson, J S |
| description | Background—The mechanisms responsible for the initiation of alcoholic pancreatitis remain elusive. However, there is an increasing body of evidence that reactive oxygen species play a role in both acute and chronic pancreatitis. In the liver, cytochrome P4502E1 (CYP2E1, the inducible ethanol metabolising enzyme) is one of the proposed pathways by which ethanol induces oxidative stress. Aims—To determine whether CYP2E1 is present in the pancreas and, if so, whether it is inducible by chronic ethanol feeding. Methods—Eighteen male Sprague-Dawley rats were pair fed liquid diets with or without ethanol as 36% of energy for four weeks. CYP2E1 levels were determined by western blotting of microsomal protein from both pancreas and liver. Messenger RNA (mRNA) levels for CYP2E1 were quantified using dot blots of total pancreatic RNA. Results—CYP2E1 was found in the pancreas. Furthermore, the amount of CYP2E1 was greater in the pancreas of rats fed ethanol compared with controls (mean increase over controls 5.1-fold, 95% confidence intervals 2.4 to 7.7, p |
| doi_str_mv | 10.1136/gut.42.3.426 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1727026</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79837233</sourcerecordid><originalsourceid>FETCH-LOGICAL-b572t-e8fc5aa82dfc1de7dc2bd45640344d44347997315e894596ecce9ad89db787f63</originalsourceid><addsrcrecordid>eNp9kUtv1DAUhSMEKtPCji2SJVDZkMHP2N4goaE8RAUIlS5YYDm20_E0sQc7Qcy_x9GMRsCCjb043z0-vqeqHiG4RIg0L26mcUnxkpSjuVMtEG1ETbAQd6sFhIjXjFN5vzrNeQMhFEKik-pEMs4JI4vq-2o3RrNOcXDgM2UQXyDgM9gml10YgQ8g6RFsdTDJ6Qx0sLPsg52Ms6DdgXk2eAPcuNYh9kDbwQefxzLmY3hQ3et0n93Dw31WfX1zcbV6V19-evt-9eqybhnHY-1EZ5jWAtvOIOu4Nbi1lDUUEkotpYRyKTlBzAlJmWycMU5qK6RtueBdQ86ql3vf7dQOzpqSPelebZMfdNqpqL36Wwl-rW7iT4U45hDPBucHgxR_TC6PavDZuL7XwcUpKy4F4ZiQAj75B9zEKYXyueJVUrKyWlqo53vKpJhzct0xCoJqbk2V1hTFipRjfv3xn_GP8KGmoj896Dob3Xep9OHzEcOoaTCDBav3WNm_-3WUdbpVDSecqY_XKwW_sS-vr_gHdV34Z3u-HTb_D_gbHCa8Jw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1779959574</pqid></control><display><type>article</type><title>Cytochrome P4502E1 is present in rat pancreas and is induced by chronic ethanol administration</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Norton, I D ; Apte, M V ; Haber, P S ; McCaughan, G W ; Pirola, R C ; Wilson, J S</creator><creatorcontrib>Norton, I D ; Apte, M V ; Haber, P S ; McCaughan, G W ; Pirola, R C ; Wilson, J S</creatorcontrib><description>Background—The mechanisms responsible for the initiation of alcoholic pancreatitis remain elusive. However, there is an increasing body of evidence that reactive oxygen species play a role in both acute and chronic pancreatitis. In the liver, cytochrome P4502E1 (CYP2E1, the inducible ethanol metabolising enzyme) is one of the proposed pathways by which ethanol induces oxidative stress. Aims—To determine whether CYP2E1 is present in the pancreas and, if so, whether it is inducible by chronic ethanol feeding. Methods—Eighteen male Sprague-Dawley rats were pair fed liquid diets with or without ethanol as 36% of energy for four weeks. CYP2E1 levels were determined by western blotting of microsomal protein from both pancreas and liver. Messenger RNA (mRNA) levels for CYP2E1 were quantified using dot blots of total pancreatic RNA. Results—CYP2E1 was found in the pancreas. Furthermore, the amount of CYP2E1 was greater in the pancreas of rats fed ethanol compared with controls (mean increase over controls 5.1-fold, 95% confidence intervals 2.4 to 7.7, p<0.02). In the liver, induction by ethanol of CYP2E1 was similar (mean increase over controls 7.9-fold, 95% confidence intervals 5.2 to 10.6, p<0.005). Pancreatic mRNA levels for CYP2E1 were similar in ethanol fed and control rats. Conclusions—CYP2E1 is present in the rat pancreas and is inducible by chronic ethanol administration. Induction of pancreatic CYP2E1 is not regulated at the mRNA level. The metabolism of ethanol via CYP2E1 may contribute to oxidative stress in the pancreas during chronic ethanol consumption.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>EISSN: 1458-3288</identifier><identifier>DOI: 10.1136/gut.42.3.426</identifier><identifier>PMID: 9577353</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Alcohol ; Alcoholism ; Animals ; Antigens ; Antioxidants ; Autoradiography ; Biological and medical sciences ; Blotting, Northern ; Blotting, Western ; chronic ethanol administration ; Cytochrome ; Cytochrome P-450 CYP2E1 - analysis ; Cytochrome P-450 CYP2E1 - drug effects ; Cytochrome P-450 CYP2E1 - genetics ; cytochrome P4502E1 ; Deoxyribonucleic acid ; Diet ; DNA ; Endoplasmic reticulum ; Enzyme Activation ; Enzymes ; Ethanol ; Ethanol - pharmacology ; Gastroenterology. Liver. Pancreas. Abdomen ; Labeling ; Liver ; Liver - drug effects ; Liver - enzymology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Membranes ; Metabolism ; Mortality ; Other diseases. Semiology ; Oxidative stress ; Pancreas ; Pancreas - drug effects ; Pancreas - enzymology ; Pathogenesis ; Proteins ; rat pancreas ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger - analysis ; Rodents ; Sodium ; Studies</subject><ispartof>Gut, 1998-03, Vol.42 (3), p.426-430</ispartof><rights>British Society of Gastroenterology</rights><rights>1998 INIST-CNRS</rights><rights>Copyright: 1998 British Society of Gastroenterology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b572t-e8fc5aa82dfc1de7dc2bd45640344d44347997315e894596ecce9ad89db787f63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1727026/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1727026/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2166250$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9577353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Norton, I D</creatorcontrib><creatorcontrib>Apte, M V</creatorcontrib><creatorcontrib>Haber, P S</creatorcontrib><creatorcontrib>McCaughan, G W</creatorcontrib><creatorcontrib>Pirola, R C</creatorcontrib><creatorcontrib>Wilson, J S</creatorcontrib><title>Cytochrome P4502E1 is present in rat pancreas and is induced by chronic ethanol administration</title><title>Gut</title><addtitle>Gut</addtitle><description>Background—The mechanisms responsible for the initiation of alcoholic pancreatitis remain elusive. However, there is an increasing body of evidence that reactive oxygen species play a role in both acute and chronic pancreatitis. In the liver, cytochrome P4502E1 (CYP2E1, the inducible ethanol metabolising enzyme) is one of the proposed pathways by which ethanol induces oxidative stress. Aims—To determine whether CYP2E1 is present in the pancreas and, if so, whether it is inducible by chronic ethanol feeding. Methods—Eighteen male Sprague-Dawley rats were pair fed liquid diets with or without ethanol as 36% of energy for four weeks. CYP2E1 levels were determined by western blotting of microsomal protein from both pancreas and liver. Messenger RNA (mRNA) levels for CYP2E1 were quantified using dot blots of total pancreatic RNA. Results—CYP2E1 was found in the pancreas. Furthermore, the amount of CYP2E1 was greater in the pancreas of rats fed ethanol compared with controls (mean increase over controls 5.1-fold, 95% confidence intervals 2.4 to 7.7, p<0.02). In the liver, induction by ethanol of CYP2E1 was similar (mean increase over controls 7.9-fold, 95% confidence intervals 5.2 to 10.6, p<0.005). Pancreatic mRNA levels for CYP2E1 were similar in ethanol fed and control rats. Conclusions—CYP2E1 is present in the rat pancreas and is inducible by chronic ethanol administration. Induction of pancreatic CYP2E1 is not regulated at the mRNA level. The metabolism of ethanol via CYP2E1 may contribute to oxidative stress in the pancreas during chronic ethanol consumption.</description><subject>Alcohol</subject><subject>Alcoholism</subject><subject>Animals</subject><subject>Antigens</subject><subject>Antioxidants</subject><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Blotting, Western</subject><subject>chronic ethanol administration</subject><subject>Cytochrome</subject><subject>Cytochrome P-450 CYP2E1 - analysis</subject><subject>Cytochrome P-450 CYP2E1 - drug effects</subject><subject>Cytochrome P-450 CYP2E1 - genetics</subject><subject>cytochrome P4502E1</subject><subject>Deoxyribonucleic acid</subject><subject>Diet</subject><subject>DNA</subject><subject>Endoplasmic reticulum</subject><subject>Enzyme Activation</subject><subject>Enzymes</subject><subject>Ethanol</subject><subject>Ethanol - pharmacology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Labeling</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membranes</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>Other diseases. Semiology</subject><subject>Oxidative stress</subject><subject>Pancreas</subject><subject>Pancreas - drug effects</subject><subject>Pancreas - enzymology</subject><subject>Pathogenesis</subject><subject>Proteins</subject><subject>rat pancreas</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - analysis</subject><subject>Rodents</subject><subject>Sodium</subject><subject>Studies</subject><issn>0017-5749</issn><issn>1468-3288</issn><issn>1458-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtv1DAUhSMEKtPCji2SJVDZkMHP2N4goaE8RAUIlS5YYDm20_E0sQc7Qcy_x9GMRsCCjb043z0-vqeqHiG4RIg0L26mcUnxkpSjuVMtEG1ETbAQd6sFhIjXjFN5vzrNeQMhFEKik-pEMs4JI4vq-2o3RrNOcXDgM2UQXyDgM9gml10YgQ8g6RFsdTDJ6Qx0sLPsg52Ms6DdgXk2eAPcuNYh9kDbwQefxzLmY3hQ3et0n93Dw31WfX1zcbV6V19-evt-9eqybhnHY-1EZ5jWAtvOIOu4Nbi1lDUUEkotpYRyKTlBzAlJmWycMU5qK6RtueBdQ86ql3vf7dQOzpqSPelebZMfdNqpqL36Wwl-rW7iT4U45hDPBucHgxR_TC6PavDZuL7XwcUpKy4F4ZiQAj75B9zEKYXyueJVUrKyWlqo53vKpJhzct0xCoJqbk2V1hTFipRjfv3xn_GP8KGmoj896Dob3Xep9OHzEcOoaTCDBav3WNm_-3WUdbpVDSecqY_XKwW_sS-vr_gHdV34Z3u-HTb_D_gbHCa8Jw</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>Norton, I D</creator><creator>Apte, M V</creator><creator>Haber, P S</creator><creator>McCaughan, G W</creator><creator>Pirola, R C</creator><creator>Wilson, J S</creator><general>BMJ Publishing Group Ltd and British Society of Gastroenterology</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19980301</creationdate><title>Cytochrome P4502E1 is present in rat pancreas and is induced by chronic ethanol administration</title><author>Norton, I D ; Apte, M V ; Haber, P S ; McCaughan, G W ; Pirola, R C ; Wilson, J S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b572t-e8fc5aa82dfc1de7dc2bd45640344d44347997315e894596ecce9ad89db787f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Alcohol</topic><topic>Alcoholism</topic><topic>Animals</topic><topic>Antigens</topic><topic>Antioxidants</topic><topic>Autoradiography</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Blotting, Western</topic><topic>chronic ethanol administration</topic><topic>Cytochrome</topic><topic>Cytochrome P-450 CYP2E1 - analysis</topic><topic>Cytochrome P-450 CYP2E1 - drug effects</topic><topic>Cytochrome P-450 CYP2E1 - genetics</topic><topic>cytochrome P4502E1</topic><topic>Deoxyribonucleic acid</topic><topic>Diet</topic><topic>DNA</topic><topic>Endoplasmic reticulum</topic><topic>Enzyme Activation</topic><topic>Enzymes</topic><topic>Ethanol</topic><topic>Ethanol - pharmacology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Labeling</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membranes</topic><topic>Metabolism</topic><topic>Mortality</topic><topic>Other diseases. Semiology</topic><topic>Oxidative stress</topic><topic>Pancreas</topic><topic>Pancreas - drug effects</topic><topic>Pancreas - enzymology</topic><topic>Pathogenesis</topic><topic>Proteins</topic><topic>rat pancreas</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - analysis</topic><topic>Rodents</topic><topic>Sodium</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Norton, I D</creatorcontrib><creatorcontrib>Apte, M V</creatorcontrib><creatorcontrib>Haber, P S</creatorcontrib><creatorcontrib>McCaughan, G W</creatorcontrib><creatorcontrib>Pirola, R C</creatorcontrib><creatorcontrib>Wilson, J S</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Norton, I D</au><au>Apte, M V</au><au>Haber, P S</au><au>McCaughan, G W</au><au>Pirola, R C</au><au>Wilson, J S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytochrome P4502E1 is present in rat pancreas and is induced by chronic ethanol administration</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>42</volume><issue>3</issue><spage>426</spage><epage>430</epage><pages>426-430</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><eissn>1458-3288</eissn><coden>GUTTAK</coden><abstract>Background—The mechanisms responsible for the initiation of alcoholic pancreatitis remain elusive. However, there is an increasing body of evidence that reactive oxygen species play a role in both acute and chronic pancreatitis. In the liver, cytochrome P4502E1 (CYP2E1, the inducible ethanol metabolising enzyme) is one of the proposed pathways by which ethanol induces oxidative stress. Aims—To determine whether CYP2E1 is present in the pancreas and, if so, whether it is inducible by chronic ethanol feeding. Methods—Eighteen male Sprague-Dawley rats were pair fed liquid diets with or without ethanol as 36% of energy for four weeks. CYP2E1 levels were determined by western blotting of microsomal protein from both pancreas and liver. Messenger RNA (mRNA) levels for CYP2E1 were quantified using dot blots of total pancreatic RNA. Results—CYP2E1 was found in the pancreas. Furthermore, the amount of CYP2E1 was greater in the pancreas of rats fed ethanol compared with controls (mean increase over controls 5.1-fold, 95% confidence intervals 2.4 to 7.7, p<0.02). In the liver, induction by ethanol of CYP2E1 was similar (mean increase over controls 7.9-fold, 95% confidence intervals 5.2 to 10.6, p<0.005). Pancreatic mRNA levels for CYP2E1 were similar in ethanol fed and control rats. Conclusions—CYP2E1 is present in the rat pancreas and is inducible by chronic ethanol administration. Induction of pancreatic CYP2E1 is not regulated at the mRNA level. The metabolism of ethanol via CYP2E1 may contribute to oxidative stress in the pancreas during chronic ethanol consumption.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><pmid>9577353</pmid><doi>10.1136/gut.42.3.426</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0017-5749 |
| ispartof | Gut, 1998-03, Vol.42 (3), p.426-430 |
| issn | 0017-5749 1468-3288 1458-3288 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1727026 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Alcohol Alcoholism Animals Antigens Antioxidants Autoradiography Biological and medical sciences Blotting, Northern Blotting, Western chronic ethanol administration Cytochrome Cytochrome P-450 CYP2E1 - analysis Cytochrome P-450 CYP2E1 - drug effects Cytochrome P-450 CYP2E1 - genetics cytochrome P4502E1 Deoxyribonucleic acid Diet DNA Endoplasmic reticulum Enzyme Activation Enzymes Ethanol Ethanol - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Labeling Liver Liver - drug effects Liver - enzymology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Membranes Metabolism Mortality Other diseases. Semiology Oxidative stress Pancreas Pancreas - drug effects Pancreas - enzymology Pathogenesis Proteins rat pancreas Rats Rats, Sprague-Dawley RNA, Messenger - analysis Rodents Sodium Studies |
| title | Cytochrome P4502E1 is present in rat pancreas and is induced by chronic ethanol administration |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T00%3A13%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytochrome%20P4502E1%20is%20present%20in%20rat%20pancreas%20and%20is%20induced%20by%20chronic%20ethanol%20administration&rft.jtitle=Gut&rft.au=Norton,%20I%20D&rft.date=1998-03-01&rft.volume=42&rft.issue=3&rft.spage=426&rft.epage=430&rft.pages=426-430&rft.issn=0017-5749&rft.eissn=1468-3288&rft.coden=GUTTAK&rft_id=info:doi/10.1136/gut.42.3.426&rft_dat=%3Cproquest_pubme%3E79837233%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1779959574&rft_id=info:pmid/9577353&rfr_iscdi=true |