Hepatitis G virus infection in chronic liver disease
Background—The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood. Aims—To evaluate the prevalence and meaning of HGV infection in a large series of patients wit...
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| Veröffentlicht in: | Gut 1998-01, Vol.42 (1), p.107-111 |
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| creator | Guilera, M Sáiz, J C López-Labrador, F X Olmedo, E Ampurdanés, S Forns, X Bruix, J Parés, A Sánchez-Tapias, J M de Anta, M T Jiménez Rodés, J |
| description | Background—The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood. Aims—To evaluate the prevalence and meaning of HGV infection in a large series of patients with chronic liver disease. Subjects—Two hundred volunteer blood donors, 179 patients with chronic hepatitis C, 111 with chronic hepatitis B, 104 with alcoholic liver disease, 136 with hepatocellular carcinoma, and 24 with cryptogenic chronic liver disease were studied. Methods—HGV RNA was investigated in serum samples by reverse transcription and polymerase chain reaction amplification of the 5′ non-coding region of HCV and hybridisation to a specific probe. The main features of HGV RNA seropositive and seronegative patients were compared. Results—The prevalence of HGV infection was 3% in blood donors, 7% in chronic hepatitis C, 8% in chronic hepatitis B, 2% in alcoholic liver disease, 4% in hepatocellular carcinoma, and 8% in cryptogenic chronic liver disease. HGV infected patients tended to be younger than non-infected patients but no differences concerning sex, possible source of infection, clinical manifestations, biochemical and virological parameters, or severity of liver lesions were found. Conclusions—The prevalence of HGV infection in chronic liver disease seems to be relatively low in our area. Infection with HGV does not seem to play a significant pathogenic role in patients with chronic liver disease related to chronic HBV or HCV infection or to increased alcohol consumption, or in those with cryptogenic chronic liver disease. |
| doi_str_mv | 10.1136/gut.42.1.107 |
| format | Article |
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Aims—To evaluate the prevalence and meaning of HGV infection in a large series of patients with chronic liver disease. Subjects—Two hundred volunteer blood donors, 179 patients with chronic hepatitis C, 111 with chronic hepatitis B, 104 with alcoholic liver disease, 136 with hepatocellular carcinoma, and 24 with cryptogenic chronic liver disease were studied. Methods—HGV RNA was investigated in serum samples by reverse transcription and polymerase chain reaction amplification of the 5′ non-coding region of HCV and hybridisation to a specific probe. The main features of HGV RNA seropositive and seronegative patients were compared. Results—The prevalence of HGV infection was 3% in blood donors, 7% in chronic hepatitis C, 8% in chronic hepatitis B, 2% in alcoholic liver disease, 4% in hepatocellular carcinoma, and 8% in cryptogenic chronic liver disease. HGV infected patients tended to be younger than non-infected patients but no differences concerning sex, possible source of infection, clinical manifestations, biochemical and virological parameters, or severity of liver lesions were found. Conclusions—The prevalence of HGV infection in chronic liver disease seems to be relatively low in our area. Infection with HGV does not seem to play a significant pathogenic role in patients with chronic liver disease related to chronic HBV or HCV infection or to increased alcohol consumption, or in those with cryptogenic chronic liver disease.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>EISSN: 1458-3288</identifier><identifier>DOI: 10.1136/gut.42.1.107</identifier><identifier>PMID: 9505895</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Adult ; Age ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biopsy ; Blood & organ donations ; Blood Donors ; Carcinoma, Hepatocellular - virology ; Chronic Disease ; Chronic diseases ; chronic liver disease ; Female ; Flaviviridae - genetics ; GB virus C ; GB virus C (GBV-C) ; Hemodialysis ; Hepatitis ; Hepatitis B - virology ; Hepatitis C - virology ; hepatitis G virus ; Hepatitis vírica ; Hepatitis, Chronic - virology ; Hepatitis, Viral, Human - complications ; Human viral diseases ; Humans ; Hypotheses ; Infections ; Infectious diseases ; Liver cancer ; Liver cirrhosis ; Liver Disease ; Liver diseases ; Liver Diseases - virology ; Liver Diseases, Alcoholic - virology ; Liver Neoplasms - virology ; Malalties cròniques ; Male ; Medical sciences ; Middle Aged ; Pathogenesis ; Polymerase Chain Reaction ; Prevalence ; RNA, Viral - analysis ; Studies ; Viral diseases ; Viral hepatitis ; Viral infections ; Viruses</subject><ispartof>Gut, 1998-01, Vol.42 (1), p.107-111</ispartof><rights>British Society of Gastroenterology</rights><rights>1998 INIST-CNRS</rights><rights>Copyright: 1998 British Society of Gastroenterology</rights><rights>(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1998 info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b548t-b4ddfcb60d049a54ea8ff4cf1573b58f1bedfa05a6f42e272657e8307e8d50f13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1726956/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1726956/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,4025,26978,27927,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2132386$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9505895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guilera, M</creatorcontrib><creatorcontrib>Sáiz, J C</creatorcontrib><creatorcontrib>López-Labrador, F X</creatorcontrib><creatorcontrib>Olmedo, E</creatorcontrib><creatorcontrib>Ampurdanés, S</creatorcontrib><creatorcontrib>Forns, X</creatorcontrib><creatorcontrib>Bruix, J</creatorcontrib><creatorcontrib>Parés, A</creatorcontrib><creatorcontrib>Sánchez-Tapias, J M</creatorcontrib><creatorcontrib>de Anta, M T Jiménez</creatorcontrib><creatorcontrib>Rodés, J</creatorcontrib><title>Hepatitis G virus infection in chronic liver disease</title><title>Gut</title><addtitle>Gut</addtitle><description>Background—The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood. Aims—To evaluate the prevalence and meaning of HGV infection in a large series of patients with chronic liver disease. Subjects—Two hundred volunteer blood donors, 179 patients with chronic hepatitis C, 111 with chronic hepatitis B, 104 with alcoholic liver disease, 136 with hepatocellular carcinoma, and 24 with cryptogenic chronic liver disease were studied. Methods—HGV RNA was investigated in serum samples by reverse transcription and polymerase chain reaction amplification of the 5′ non-coding region of HCV and hybridisation to a specific probe. The main features of HGV RNA seropositive and seronegative patients were compared. Results—The prevalence of HGV infection was 3% in blood donors, 7% in chronic hepatitis C, 8% in chronic hepatitis B, 2% in alcoholic liver disease, 4% in hepatocellular carcinoma, and 8% in cryptogenic chronic liver disease. HGV infected patients tended to be younger than non-infected patients but no differences concerning sex, possible source of infection, clinical manifestations, biochemical and virological parameters, or severity of liver lesions were found. Conclusions—The prevalence of HGV infection in chronic liver disease seems to be relatively low in our area. Infection with HGV does not seem to play a significant pathogenic role in patients with chronic liver disease related to chronic HBV or HCV infection or to increased alcohol consumption, or in those with cryptogenic chronic liver disease.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Blood & organ donations</subject><subject>Blood Donors</subject><subject>Carcinoma, Hepatocellular - virology</subject><subject>Chronic Disease</subject><subject>Chronic diseases</subject><subject>chronic liver disease</subject><subject>Female</subject><subject>Flaviviridae - genetics</subject><subject>GB virus C</subject><subject>GB virus C (GBV-C)</subject><subject>Hemodialysis</subject><subject>Hepatitis</subject><subject>Hepatitis B - virology</subject><subject>Hepatitis C - virology</subject><subject>hepatitis G virus</subject><subject>Hepatitis vírica</subject><subject>Hepatitis, Chronic - virology</subject><subject>Hepatitis, Viral, Human - complications</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver Disease</subject><subject>Liver diseases</subject><subject>Liver Diseases - virology</subject><subject>Liver Diseases, Alcoholic - virology</subject><subject>Liver Neoplasms - virology</subject><subject>Malalties cròniques</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathogenesis</subject><subject>Polymerase Chain Reaction</subject><subject>Prevalence</subject><subject>RNA, Viral - analysis</subject><subject>Studies</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Viral infections</subject><subject>Viruses</subject><issn>0017-5749</issn><issn>1468-3288</issn><issn>1458-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>XX2</sourceid><recordid>eNp9kU2LFDEQhoMo6-zqzavQoODFHvPZSS6CDLrrsCjCqseQTld2M850j0l6WP-9Gadp9OIhn-9bT1VRCD0jeEkIa97cjnnJ6ZIsCZYP0ILwRtWMKvUQLTAmshaS68foPKUNxlgpTc7QmRZYKC0WiF_B3uaQQ6ouq0OIY6pC78HlMPTlVrm7OPTBVdtwgFh1IYFN8AQ98nab4Ol0XqCvH97frK7q68-XH1fvrutWcJXrlnedd22DO8y1FRys8p47T4RkrVCetNB5i4VtPKdAJW2EBMVw2TqBPWEX6O2Jux_bHXQO-hzt1uxj2Nn4yww2mH-VPtyZ2-FgSGFp0RQAOQFcGp2J4CA6m_8Ezo_jolhSQxop1DHpiylpHH6OkLLZDGPsS58FK7VmkmJeXK8nchxSiuDnqgg2x7GYMhbDC7V8yGJ__ncns3maQ9FfTrpNzm59tL0LabZRwihTx37qky2kDPezbOMP00gmhfn0bWXWX9Zrvbr5bmjxvzr5293m_wX-BgaasW8</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Guilera, M</creator><creator>Sáiz, J C</creator><creator>López-Labrador, F X</creator><creator>Olmedo, E</creator><creator>Ampurdanés, S</creator><creator>Forns, X</creator><creator>Bruix, J</creator><creator>Parés, A</creator><creator>Sánchez-Tapias, J M</creator><creator>de Anta, M T Jiménez</creator><creator>Rodés, J</creator><general>BMJ Publishing Group Ltd and British Society of Gastroenterology</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>XX2</scope><scope>5PM</scope></search><sort><creationdate>199801</creationdate><title>Hepatitis G virus infection in chronic liver disease</title><author>Guilera, M ; Sáiz, J C ; López-Labrador, F X ; Olmedo, E ; Ampurdanés, S ; Forns, X ; Bruix, J ; Parés, A ; Sánchez-Tapias, J M ; de Anta, M T Jiménez ; Rodés, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b548t-b4ddfcb60d049a54ea8ff4cf1573b58f1bedfa05a6f42e272657e8307e8d50f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Blood & organ donations</topic><topic>Blood Donors</topic><topic>Carcinoma, Hepatocellular - virology</topic><topic>Chronic Disease</topic><topic>Chronic diseases</topic><topic>chronic liver disease</topic><topic>Female</topic><topic>Flaviviridae - genetics</topic><topic>GB virus C</topic><topic>GB virus C (GBV-C)</topic><topic>Hemodialysis</topic><topic>Hepatitis</topic><topic>Hepatitis B - virology</topic><topic>Hepatitis C - virology</topic><topic>hepatitis G virus</topic><topic>Hepatitis vírica</topic><topic>Hepatitis, Chronic - virology</topic><topic>Hepatitis, Viral, Human - complications</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver Disease</topic><topic>Liver diseases</topic><topic>Liver Diseases - virology</topic><topic>Liver Diseases, Alcoholic - virology</topic><topic>Liver Neoplasms - virology</topic><topic>Malalties cròniques</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pathogenesis</topic><topic>Polymerase Chain Reaction</topic><topic>Prevalence</topic><topic>RNA, Viral - analysis</topic><topic>Studies</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Viral infections</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guilera, M</creatorcontrib><creatorcontrib>Sáiz, J C</creatorcontrib><creatorcontrib>López-Labrador, F X</creatorcontrib><creatorcontrib>Olmedo, E</creatorcontrib><creatorcontrib>Ampurdanés, S</creatorcontrib><creatorcontrib>Forns, X</creatorcontrib><creatorcontrib>Bruix, J</creatorcontrib><creatorcontrib>Parés, A</creatorcontrib><creatorcontrib>Sánchez-Tapias, J M</creatorcontrib><creatorcontrib>de Anta, M T Jiménez</creatorcontrib><creatorcontrib>Rodés, J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Recercat</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guilera, M</au><au>Sáiz, J C</au><au>López-Labrador, F X</au><au>Olmedo, E</au><au>Ampurdanés, S</au><au>Forns, X</au><au>Bruix, J</au><au>Parés, A</au><au>Sánchez-Tapias, J M</au><au>de Anta, M T Jiménez</au><au>Rodés, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis G virus infection in chronic liver disease</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>1998-01</date><risdate>1998</risdate><volume>42</volume><issue>1</issue><spage>107</spage><epage>111</epage><pages>107-111</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><eissn>1458-3288</eissn><coden>GUTTAK</coden><abstract>Background—The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood. Aims—To evaluate the prevalence and meaning of HGV infection in a large series of patients with chronic liver disease. Subjects—Two hundred volunteer blood donors, 179 patients with chronic hepatitis C, 111 with chronic hepatitis B, 104 with alcoholic liver disease, 136 with hepatocellular carcinoma, and 24 with cryptogenic chronic liver disease were studied. Methods—HGV RNA was investigated in serum samples by reverse transcription and polymerase chain reaction amplification of the 5′ non-coding region of HCV and hybridisation to a specific probe. The main features of HGV RNA seropositive and seronegative patients were compared. Results—The prevalence of HGV infection was 3% in blood donors, 7% in chronic hepatitis C, 8% in chronic hepatitis B, 2% in alcoholic liver disease, 4% in hepatocellular carcinoma, and 8% in cryptogenic chronic liver disease. HGV infected patients tended to be younger than non-infected patients but no differences concerning sex, possible source of infection, clinical manifestations, biochemical and virological parameters, or severity of liver lesions were found. Conclusions—The prevalence of HGV infection in chronic liver disease seems to be relatively low in our area. Infection with HGV does not seem to play a significant pathogenic role in patients with chronic liver disease related to chronic HBV or HCV infection or to increased alcohol consumption, or in those with cryptogenic chronic liver disease.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><pmid>9505895</pmid><doi>10.1136/gut.42.1.107</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Aged, 80 and over Biological and medical sciences Biopsy Blood & organ donations Blood Donors Carcinoma, Hepatocellular - virology Chronic Disease Chronic diseases chronic liver disease Female Flaviviridae - genetics GB virus C GB virus C (GBV-C) Hemodialysis Hepatitis Hepatitis B - virology Hepatitis C - virology hepatitis G virus Hepatitis vírica Hepatitis, Chronic - virology Hepatitis, Viral, Human - complications Human viral diseases Humans Hypotheses Infections Infectious diseases Liver cancer Liver cirrhosis Liver Disease Liver diseases Liver Diseases - virology Liver Diseases, Alcoholic - virology Liver Neoplasms - virology Malalties cròniques Male Medical sciences Middle Aged Pathogenesis Polymerase Chain Reaction Prevalence RNA, Viral - analysis Studies Viral diseases Viral hepatitis Viral infections Viruses |
| title | Hepatitis G virus infection in chronic liver disease |
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