Accidental human poisoning with a veterinary tranquilliser
DISCUSSION Detomidine (trade names Domosedan and Dormosedan) is used for sedating horses and other animals to facilitate examination and surgical procedures. 1, 2 Detomidine causes a bradycardia with blood pressure initially raised and then normal or low, reduced cardiac output, and slowing of intra...
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| Veröffentlicht in: | Emergency medicine journal : EMJ 2005-07, Vol.22 (7), p.524-525 |
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| description | DISCUSSION Detomidine (trade names Domosedan and Dormosedan) is used for sedating horses and other animals to facilitate examination and surgical procedures. 1, 2 Detomidine causes a bradycardia with blood pressure initially raised and then normal or low, reduced cardiac output, and slowing of intracardiac conduction with partial sinoatrial and atrioventricular block. The only previous report of detomidine poisoning in humans is a single case of deliberate injection of detomidine 50 mg and butorphanol 100 mg in a 36 year old man. 8 Butorphanol is an opioid drug for which the antidote is naloxone. 9 The patient presented with a GCS of 6 and required a continuous infusion of naloxone, but his heart rate never fell below 70 beats/min and his blood pressure never below 110/80 mmHg. |
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The only previous report of detomidine poisoning in humans is a single case of deliberate injection of detomidine 50 mg and butorphanol 100 mg in a 36 year old man. 8 Butorphanol is an opioid drug for which the antidote is naloxone. 9 The patient presented with a GCS of 6 and required a continuous infusion of naloxone, but his heart rate never fell below 70 beats/min and his blood pressure never below 110/80 mmHg.</description><identifier>ISSN: 1472-0205</identifier><identifier>EISSN: 1472-0213</identifier><identifier>PMID: 15983098</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and the British Association for Accident & Emergency Medicine</publisher><subject>Accidents, Occupational ; Adrenergic alpha-Agonists - poisoning ; Adult ; Analgesics ; Anesthesia ; Animal Husbandry ; Animals ; Blood pressure ; Cardiac arrhythmia ; Case Report ; Cattle ; Detomidine ; domosedan ; dormosedan ; Heart rate ; Humans ; Hypnotics and Sedatives - poisoning ; Imidazoles - poisoning ; Male ; overdose ; Poisoning ; tranquilliser ; Veterinary Drugs - poisoning ; Veterinary medicine</subject><ispartof>Emergency medicine journal : EMJ, 2005-07, Vol.22 (7), p.524-525</ispartof><rights>Copyright 2005 by the Emergency Medicine Journal</rights><rights>Copyright: 2005 Copyright 2005 by the Emergency Medicine Journal</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1726842/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1726842/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15983098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cummins, F H</creatorcontrib><title>Accidental human poisoning with a veterinary tranquilliser</title><title>Emergency medicine journal : EMJ</title><addtitle>Emerg Med J</addtitle><description>DISCUSSION Detomidine (trade names Domosedan and Dormosedan) is used for sedating horses and other animals to facilitate examination and surgical procedures. 1, 2 Detomidine causes a bradycardia with blood pressure initially raised and then normal or low, reduced cardiac output, and slowing of intracardiac conduction with partial sinoatrial and atrioventricular block. The only previous report of detomidine poisoning in humans is a single case of deliberate injection of detomidine 50 mg and butorphanol 100 mg in a 36 year old man. 8 Butorphanol is an opioid drug for which the antidote is naloxone. 9 The patient presented with a GCS of 6 and required a continuous infusion of naloxone, but his heart rate never fell below 70 beats/min and his blood pressure never below 110/80 mmHg.</description><subject>Accidents, Occupational</subject><subject>Adrenergic alpha-Agonists - poisoning</subject><subject>Adult</subject><subject>Analgesics</subject><subject>Anesthesia</subject><subject>Animal Husbandry</subject><subject>Animals</subject><subject>Blood pressure</subject><subject>Cardiac arrhythmia</subject><subject>Case Report</subject><subject>Cattle</subject><subject>Detomidine</subject><subject>domosedan</subject><subject>dormosedan</subject><subject>Heart rate</subject><subject>Humans</subject><subject>Hypnotics and Sedatives - poisoning</subject><subject>Imidazoles - poisoning</subject><subject>Male</subject><subject>overdose</subject><subject>Poisoning</subject><subject>tranquilliser</subject><subject>Veterinary Drugs - poisoning</subject><subject>Veterinary medicine</subject><issn>1472-0205</issn><issn>1472-0213</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVkF1LwzAUhoMobk7_ghS8LuSrbSYojPk5pt5Mb0OSpmtmm25pOvXfG9ksenE44Zwn73nPOQBDRDMcQ4zIYf-GyQCctO0KQpSMKTsGg5AZgWM2BJcTpUyurRdVVHa1sNG6MW1jjV1GH8aXkYi22mtnrHBfkXfCbjpTVabV7hQcFaJq9dk-j8Dr3e1i-hDPX-4fp5N5LAmjPi4QRAxrohiSGGVinOZaCgkzVqRU5ARJRIIfqZnAtEgoUkJRmQiIVIp0mpIRuN7prjtZ61wFs05UfO1MHTzxRhj-v2NNyZfNlqMMp4ziIHCxF3DNptOt56umczZ4DgiDEJIkxAic_x3T6__eKgDxDjCt1599X7h3nmYkS_jz25Q_zWYJposZvwn81Y6X9aqnS-_XXIfCT1E1dQjrg2-OMc94-MqLrgrL5QX5BmpZjW4</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Cummins, F H</creator><general>BMJ Publishing Group Ltd and the British Association for Accident & Emergency Medicine</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RQ</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>U9A</scope><scope>5PM</scope></search><sort><creationdate>200507</creationdate><title>Accidental human poisoning with a veterinary tranquilliser</title><author>Cummins, F H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b384t-f10182e3c81b217a96debab078f64ad31b13159be8a24f541cac4b5a01c61e663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Accidents, Occupational</topic><topic>Adrenergic alpha-Agonists - poisoning</topic><topic>Adult</topic><topic>Analgesics</topic><topic>Anesthesia</topic><topic>Animal Husbandry</topic><topic>Animals</topic><topic>Blood pressure</topic><topic>Cardiac arrhythmia</topic><topic>Case Report</topic><topic>Cattle</topic><topic>Detomidine</topic><topic>domosedan</topic><topic>dormosedan</topic><topic>Heart rate</topic><topic>Humans</topic><topic>Hypnotics and Sedatives - poisoning</topic><topic>Imidazoles - poisoning</topic><topic>Male</topic><topic>overdose</topic><topic>Poisoning</topic><topic>tranquilliser</topic><topic>Veterinary Drugs - poisoning</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cummins, F H</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Emergency medicine journal : EMJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cummins, F H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accidental human poisoning with a veterinary tranquilliser</atitle><jtitle>Emergency medicine journal : EMJ</jtitle><addtitle>Emerg Med J</addtitle><date>2005-07</date><risdate>2005</risdate><volume>22</volume><issue>7</issue><spage>524</spage><epage>525</epage><pages>524-525</pages><issn>1472-0205</issn><eissn>1472-0213</eissn><abstract>DISCUSSION Detomidine (trade names Domosedan and Dormosedan) is used for sedating horses and other animals to facilitate examination and surgical procedures. 1, 2 Detomidine causes a bradycardia with blood pressure initially raised and then normal or low, reduced cardiac output, and slowing of intracardiac conduction with partial sinoatrial and atrioventricular block. The only previous report of detomidine poisoning in humans is a single case of deliberate injection of detomidine 50 mg and butorphanol 100 mg in a 36 year old man. 8 Butorphanol is an opioid drug for which the antidote is naloxone. 9 The patient presented with a GCS of 6 and required a continuous infusion of naloxone, but his heart rate never fell below 70 beats/min and his blood pressure never below 110/80 mmHg.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and the British Association for Accident & Emergency Medicine</pub><pmid>15983098</pmid><tpages>2</tpages></addata></record> |
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| subjects | Accidents, Occupational Adrenergic alpha-Agonists - poisoning Adult Analgesics Anesthesia Animal Husbandry Animals Blood pressure Cardiac arrhythmia Case Report Cattle Detomidine domosedan dormosedan Heart rate Humans Hypnotics and Sedatives - poisoning Imidazoles - poisoning Male overdose Poisoning tranquilliser Veterinary Drugs - poisoning Veterinary medicine |
| title | Accidental human poisoning with a veterinary tranquilliser |
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