Effect of alcohol and light on the retinal pigment epithelium of normal subjects and patients with retinal dystrophies
BACKGROUND Light absorbed by photoreceptors causes oscillations in the voltage across the retinal pigment epithelium (RPE). This is the basis of the clinical test, electro-oculography (EOG). We have previously shown that alcohol causes a sequence of voltage changes which are so precisely the same as...
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| Veröffentlicht in: | British journal of ophthalmology 2000-08, Vol.84 (8), p.881-883 |
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| container_title | British journal of ophthalmology |
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| creator | Arden, G B Wolf, J E Singbartl, F Berninger, T E Rudolph, G Kampik, A |
| description | BACKGROUND Light absorbed by photoreceptors causes oscillations in the voltage across the retinal pigment epithelium (RPE). This is the basis of the clinical test, electro-oculography (EOG). We have previously shown that alcohol causes a sequence of voltage changes which are so precisely the same as those caused by light that they must be produced by the same RPE machinery. There is good evidence that alcohol produces its effect by a direct action on the RPE. Consequently, in diseases associated with loss of photoreceptors, alcohol should continue to produce the voltage changes of the EOG unless secondary changes have occurred in the RPE. METHODS The alcohol response in patients with retinitis pigmentosa (RP) was investigated using EOG. RESULTS In no patient with RP was there any alcohol rise. CONCLUSION In patients with RP secondary abnormalities of function of the RPE must occur. |
| doi_str_mv | 10.1136/bjo.84.8.881 |
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This is the basis of the clinical test, electro-oculography (EOG). We have previously shown that alcohol causes a sequence of voltage changes which are so precisely the same as those caused by light that they must be produced by the same RPE machinery. There is good evidence that alcohol produces its effect by a direct action on the RPE. Consequently, in diseases associated with loss of photoreceptors, alcohol should continue to produce the voltage changes of the EOG unless secondary changes have occurred in the RPE. METHODS The alcohol response in patients with retinitis pigmentosa (RP) was investigated using EOG. RESULTS In no patient with RP was there any alcohol rise. CONCLUSION In patients with RP secondary abnormalities of function of the RPE must occur.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.84.8.881</identifier><identifier>PMID: 10906096</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Adult ; Aged ; alcohol ; Alcohol Drinking - adverse effects ; Biological and medical sciences ; Humans ; Light ; Medical sciences ; Middle Aged ; Ophthalmology ; Original articles - Clinical science ; Pigment Epithelium of Eye - drug effects ; Pigment Epithelium of Eye - radiation effects ; retinal pigment epithelium ; retinitis pigmentosa ; Retinitis Pigmentosa - etiology ; Retinopathies</subject><ispartof>British journal of ophthalmology, 2000-08, Vol.84 (8), p.881-883</ispartof><rights>British Journal of Ophthalmology</rights><rights>2000 INIST-CNRS</rights><rights>Copyright: 2000 British Journal of Ophthalmology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b507t-39bdceb3423d671a1c76544a1ef424a0b1f4aa4e2dda795254f3102b48dc75833</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1723570/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1723570/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1445638$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10906096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arden, G B</creatorcontrib><creatorcontrib>Wolf, J E</creatorcontrib><creatorcontrib>Singbartl, F</creatorcontrib><creatorcontrib>Berninger, T E</creatorcontrib><creatorcontrib>Rudolph, G</creatorcontrib><creatorcontrib>Kampik, A</creatorcontrib><title>Effect of alcohol and light on the retinal pigment epithelium of normal subjects and patients with retinal dystrophies</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>BACKGROUND Light absorbed by photoreceptors causes oscillations in the voltage across the retinal pigment epithelium (RPE). This is the basis of the clinical test, electro-oculography (EOG). We have previously shown that alcohol causes a sequence of voltage changes which are so precisely the same as those caused by light that they must be produced by the same RPE machinery. There is good evidence that alcohol produces its effect by a direct action on the RPE. Consequently, in diseases associated with loss of photoreceptors, alcohol should continue to produce the voltage changes of the EOG unless secondary changes have occurred in the RPE. METHODS The alcohol response in patients with retinitis pigmentosa (RP) was investigated using EOG. RESULTS In no patient with RP was there any alcohol rise. CONCLUSION In patients with RP secondary abnormalities of function of the RPE must occur.</description><subject>Adult</subject><subject>Aged</subject><subject>alcohol</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Humans</subject><subject>Light</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Original articles - Clinical science</subject><subject>Pigment Epithelium of Eye - drug effects</subject><subject>Pigment Epithelium of Eye - radiation effects</subject><subject>retinal pigment epithelium</subject><subject>retinitis pigmentosa</subject><subject>Retinitis Pigmentosa - etiology</subject><subject>Retinopathies</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90U1v1DAQBmALgehSuHFGkUDlQhZ_xXYuSHRVClL5kCjlaDmJs3Fw4mA7hf57vGS1FA4crMieZ15NNAA8RnCNEGEvq96tBV2LtRDoDlghykSOIS_vghWEkOcIMXQEHoTQpytmiN8HRwiWkMGSrcD1WdvqOmauzZStXedspsYms2bbpccxi53OvI5mVDabzHbQY8z0ZNKzNfOwaxudH1IxzFWfgsLv9klFk2TIfiR56G9uQvRu6owOD8G9VtmgH-2_x-DLm7PLzdv84uP5u83ri7wqII85Kaum1hWhmDSMI4VqzgpKFdItxVTBCrVUKapx0yheFrigLUEQV1Q0NS8EIcfg1ZI7zdWgU9YYvbJy8mZQ_kY6ZeTfldF0cuuuJeKYFBymgJN9gHffZx2iHEyotbVq1G4OkiNMC8pQgk__gb2bffrtkLJ4uTuYJvViUbV3IXjdHkZBUO7WKdM6paBSyLTOxJ_cHv8WXvaXwLM9UKFWtvVqrE344ygtGBGJ5QszIeqfh7Ly3yTjhBfyw9VGnuLLT1dfzz_L98k_X3w19P-f8Bf_j8Zi</recordid><startdate>20000801</startdate><enddate>20000801</enddate><creator>Arden, G B</creator><creator>Wolf, J E</creator><creator>Singbartl, F</creator><creator>Berninger, T E</creator><creator>Rudolph, G</creator><creator>Kampik, A</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20000801</creationdate><title>Effect of alcohol and light on the retinal pigment epithelium of normal subjects and patients with retinal dystrophies</title><author>Arden, G B ; Wolf, J E ; Singbartl, F ; Berninger, T E ; Rudolph, G ; Kampik, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b507t-39bdceb3423d671a1c76544a1ef424a0b1f4aa4e2dda795254f3102b48dc75833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>alcohol</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Humans</topic><topic>Light</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Original articles - Clinical science</topic><topic>Pigment Epithelium of Eye - drug effects</topic><topic>Pigment Epithelium of Eye - radiation effects</topic><topic>retinal pigment epithelium</topic><topic>retinitis pigmentosa</topic><topic>Retinitis Pigmentosa - etiology</topic><topic>Retinopathies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arden, G B</creatorcontrib><creatorcontrib>Wolf, J E</creatorcontrib><creatorcontrib>Singbartl, F</creatorcontrib><creatorcontrib>Berninger, T E</creatorcontrib><creatorcontrib>Rudolph, G</creatorcontrib><creatorcontrib>Kampik, A</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arden, G B</au><au>Wolf, J E</au><au>Singbartl, F</au><au>Berninger, T E</au><au>Rudolph, G</au><au>Kampik, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of alcohol and light on the retinal pigment epithelium of normal subjects and patients with retinal dystrophies</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>2000-08-01</date><risdate>2000</risdate><volume>84</volume><issue>8</issue><spage>881</spage><epage>883</epage><pages>881-883</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>BACKGROUND Light absorbed by photoreceptors causes oscillations in the voltage across the retinal pigment epithelium (RPE). 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| subjects | Adult Aged alcohol Alcohol Drinking - adverse effects Biological and medical sciences Humans Light Medical sciences Middle Aged Ophthalmology Original articles - Clinical science Pigment Epithelium of Eye - drug effects Pigment Epithelium of Eye - radiation effects retinal pigment epithelium retinitis pigmentosa Retinitis Pigmentosa - etiology Retinopathies |
| title | Effect of alcohol and light on the retinal pigment epithelium of normal subjects and patients with retinal dystrophies |
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