Regulation of plasminogen activation by TGF-β in cultured human retinal endothelial cells

BACKGROUND/AIMS Regulation of plasmin mediated extracellular matrix degradation by vascular endothelial cells is important in the development of angiogenesis. The aim was to determine whether transforming growth factor β (TGF-β) affected the regulation of components of the plasminogen system by huma...

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Veröffentlicht in:	British journal of ophthalmology 2000-04, Vol.84 (4), p.417-422
Hauptverfasser:	Wileman, Samantha M, Booth, Nuala A, Moore, Norma, Redmill, Brian, Forrester, John V, Knott, Rachel M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Culture Techniques Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Fibrin - metabolism Glucose - pharmacology human retinal endothelial cells Humans Immunoenzyme Techniques Medical sciences Ophthalmology Original articles - Laboratory science plasminogen Plasminogen - physiology Plasminogen Activator Inhibitor 1 - metabolism Plasminogen Activators - metabolism Retinal Vessels - drug effects Retinal Vessels - metabolism Retinopathies Tissue Plasminogen Activator - metabolism Transforming Growth Factor beta - pharmacology transforming growth factor β Urokinase-Type Plasminogen Activator - metabolism
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