Hypertension and diabetic retinopathy—what’s the story?
In type 1 diabetes the development of diabetic nephropathy may play a major role in the subsequent development of hypertension since microalbuminuria is present in about 80% of type 1 diabetic subjects before the onset of hypertension. 7 The pathogenesis of hypertension in type 2 diabetes is not so...
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| Veröffentlicht in: | British journal of ophthalmology 1999-09, Vol.83 (9), p.1083-1087 |
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| container_title | British journal of ophthalmology |
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| creator | GILLOW, J T GIBSON, J M DODSON, P M |
| description | In type 1 diabetes the development of diabetic nephropathy may play a major role in the subsequent development of hypertension since microalbuminuria is present in about 80% of type 1 diabetic subjects before the onset of hypertension. 7 The pathogenesis of hypertension in type 2 diabetes is not so clear, with a lesser significance for nephropathy, with microalbuminuria predating hypertension in approximately 25% of type 2 diabetic subjects with hypertension. 7 Other relevant factors in type 2 diabetes are decreased baroceptor sensitivity, increased peripheral vascular resistance from enhanced smooth muscle contractility, and vascular structural changes including protein glycosylation and increased type IV collagen. 8 Additionally, hyperglycaemia causes increased function of the sodium/glucose proximal convoluted tubule co-transporter leading to sodium retention. The results of controlled prospective studies using antihypertensive agents to prevent the development of diabetic retinopathy have been awaited with interest. [...]1998 at least in type 2 diabetes the likely benefits of treatment of hypertension has been assumed from extrapolation of large treatment trials in non-diabetic subjects. |
| doi_str_mv | 10.1136/bjo.83.9.1083 |
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The results of controlled prospective studies using antihypertensive agents to prevent the development of diabetic retinopathy have been awaited with interest. [...]1998 at least in type 2 diabetes the likely benefits of treatment of hypertension has been assumed from extrapolation of large treatment trials in non-diabetic subjects.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.83.9.1083</identifier><identifier>PMID: 10460781</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Age ; Antihypertensive Agents - therapeutic use ; Associated diseases and complications ; Biological and medical sciences ; Blood pressure ; Diabetes ; Diabetes. Impaired glucose tolerance ; Diabetic retinopathy ; Diabetic Retinopathy - etiology ; Disease Progression ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - drug therapy ; Insulin ; Insulin resistance ; Lasers ; Medical personnel ; Medical sciences ; Metabolism ; Pathogenesis ; Population ; Professional Practice ; Retina ; Studies ; Visual impairment</subject><ispartof>British journal of ophthalmology, 1999-09, Vol.83 (9), p.1083-1087</ispartof><rights>British Journal of Ophthalmology</rights><rights>1999 INIST-CNRS</rights><rights>Copyright: 1999 British Journal of Ophthalmology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b511t-45997b9463a7dfb3c307c70aa17a7aee1f22254adae7e6702bdd15b0753042a23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1723193/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1723193/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,313,314,727,780,784,792,885,27922,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1939023$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10460781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GILLOW, J T</creatorcontrib><creatorcontrib>GIBSON, J M</creatorcontrib><creatorcontrib>DODSON, P M</creatorcontrib><title>Hypertension and diabetic retinopathy—what’s the story?</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>In type 1 diabetes the development of diabetic nephropathy may play a major role in the subsequent development of hypertension since microalbuminuria is present in about 80% of type 1 diabetic subjects before the onset of hypertension. 7 The pathogenesis of hypertension in type 2 diabetes is not so clear, with a lesser significance for nephropathy, with microalbuminuria predating hypertension in approximately 25% of type 2 diabetic subjects with hypertension. 7 Other relevant factors in type 2 diabetes are decreased baroceptor sensitivity, increased peripheral vascular resistance from enhanced smooth muscle contractility, and vascular structural changes including protein glycosylation and increased type IV collagen. 8 Additionally, hyperglycaemia causes increased function of the sodium/glucose proximal convoluted tubule co-transporter leading to sodium retention. The results of controlled prospective studies using antihypertensive agents to prevent the development of diabetic retinopathy have been awaited with interest. [...]1998 at least in type 2 diabetes the likely benefits of treatment of hypertension has been assumed from extrapolation of large treatment trials in non-diabetic subjects.</description><subject>Age</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - etiology</subject><subject>Disease Progression</subject><subject>Endocrine pancreas. 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Impaired glucose tolerance</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - etiology</topic><topic>Disease Progression</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - complications</topic><topic>Hypertension - drug therapy</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Lasers</topic><topic>Medical personnel</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Pathogenesis</topic><topic>Population</topic><topic>Professional Practice</topic><topic>Retina</topic><topic>Studies</topic><topic>Visual impairment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GILLOW, J T</creatorcontrib><creatorcontrib>GIBSON, J M</creatorcontrib><creatorcontrib>DODSON, P M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GILLOW, J T</au><au>GIBSON, J M</au><au>DODSON, P M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypertension and diabetic retinopathy—what’s the story?</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>1999-09-01</date><risdate>1999</risdate><volume>83</volume><issue>9</issue><spage>1083</spage><epage>1087</epage><pages>1083-1087</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>In type 1 diabetes the development of diabetic nephropathy may play a major role in the subsequent development of hypertension since microalbuminuria is present in about 80% of type 1 diabetic subjects before the onset of hypertension. 7 The pathogenesis of hypertension in type 2 diabetes is not so clear, with a lesser significance for nephropathy, with microalbuminuria predating hypertension in approximately 25% of type 2 diabetic subjects with hypertension. 7 Other relevant factors in type 2 diabetes are decreased baroceptor sensitivity, increased peripheral vascular resistance from enhanced smooth muscle contractility, and vascular structural changes including protein glycosylation and increased type IV collagen. 8 Additionally, hyperglycaemia causes increased function of the sodium/glucose proximal convoluted tubule co-transporter leading to sodium retention. 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| subjects | Age Antihypertensive Agents - therapeutic use Associated diseases and complications Biological and medical sciences Blood pressure Diabetes Diabetes. Impaired glucose tolerance Diabetic retinopathy Diabetic Retinopathy - etiology Disease Progression Endocrine pancreas. Apud cells (diseases) Endocrinopathies Humans Hypertension Hypertension - complications Hypertension - drug therapy Insulin Insulin resistance Lasers Medical personnel Medical sciences Metabolism Pathogenesis Population Professional Practice Retina Studies Visual impairment |
| title | Hypertension and diabetic retinopathy—what’s the story? |
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