Preperimetric glaucoma diagnosis by confocal scanning laser tomography of the optic disc
AIM To evaluate the ability of confocal scanning laser tomography of the optic nerve head to detect glaucomatous optic nerve damage in ocular hypertensive eyes without visual field defects. METHODS The study included 50 normal subjects, 61 glaucoma patients with glaucomatous changes in the optic dis...
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| Veröffentlicht in: | British journal of ophthalmology 1999-03, Vol.83 (3), p.299-304 |
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| creator | Mardin, Christian Y Horn, Folkert K Jonas, Jost B Budde, Wido M |
| description | AIM To evaluate the ability of confocal scanning laser tomography of the optic nerve head to detect glaucomatous optic nerve damage in ocular hypertensive eyes without visual field defects. METHODS The study included 50 normal subjects, 61 glaucoma patients with glaucomatous changes in the optic disc and visual field, and 102 “preperimetric” patients with increased intraocular pressure, normal visual fields, and glaucomatous appearance of the optic disc as evaluated on colour stereo optic disc photographs. For all individuals, confocal scanning laser tomographs of the optic nerve head were taken using the Heidelberg retina tomograph (HRT; software 2.01). RESULTS Almost all investigated HRT variables varied significantly (p |
| doi_str_mv | 10.1136/bjo.83.3.299 |
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METHODS The study included 50 normal subjects, 61 glaucoma patients with glaucomatous changes in the optic disc and visual field, and 102 “preperimetric” patients with increased intraocular pressure, normal visual fields, and glaucomatous appearance of the optic disc as evaluated on colour stereo optic disc photographs. For all individuals, confocal scanning laser tomographs of the optic nerve head were taken using the Heidelberg retina tomograph (HRT; software 2.01). RESULTS Almost all investigated HRT variables varied significantly (p<0.05) between the normal eyes and preperimetric glaucoma eyes with pronounced overlap between the two study groups. Corresponding to the overlap, sensitivity and specificity values were relatively low when HRT variables were taken to differentiate between normal and preperimetric glaucoma eyes. At a given specificity of 95% highest sensitivities were found for the variables “rim area in the superior disc sector” (24.8%), “nerve fibre layer thickness in the inferior disc sector” (26.5%), and “rim volume in the superior disc sector” (25.5%). A multivariate approach increased sensitivity to 42.2% at a given specificity of 95%. For the glaucoma group highest sensitivity values were reached by rim volume in the superior disc sector (73.8%) and rim area (72.1%); the multivariate approach reached 83.6%. CONCLUSIONS Owing to pronounced overlapping between the groups, confocal scanning laser tomography of the optic nerve head has relatively low diagnostic power to differentiate between normal eyes and preperimetric glaucoma eyes. One of the reasons may be the biological interindividual variability of quantitative optic disc variables.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.83.3.299</identifier><identifier>PMID: 10365037</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; confocal scanning laser tomography ; Cross-Sectional Studies ; Defects ; Discriminant analysis ; Glaucoma ; Glaucoma, Open-Angle - diagnosis ; Glaucoma, Open-Angle - physiopathology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lasers ; Medical sciences ; Microscopy, Confocal ; Middle Aged ; Morphology ; Multivariate analysis ; Nerve Fibers - pathology ; optic disc ; Optic Disk - pathology ; Optic nerve ; Original ; Otorhinolaryngology. Stomatology. Orbit ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Retina ; Retina - pathology ; ROC Curve ; Sensitivity and Specificity ; Software ; Studies ; Tomography ; Variables ; Visual Field Tests ; Visual Fields</subject><ispartof>British journal of ophthalmology, 1999-03, Vol.83 (3), p.299-304</ispartof><rights>British Journal of Ophthalmology</rights><rights>1999 INIST-CNRS</rights><rights>Copyright: 1999 British Journal of Ophthalmology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b507t-efb110b55797405c7abf995184d85067d08c0b3b78d9115e739567a3dc2d0193</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1722981/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1722981/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1721582$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10365037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mardin, Christian Y</creatorcontrib><creatorcontrib>Horn, Folkert K</creatorcontrib><creatorcontrib>Jonas, Jost B</creatorcontrib><creatorcontrib>Budde, Wido M</creatorcontrib><title>Preperimetric glaucoma diagnosis by confocal scanning laser tomography of the optic disc</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>AIM To evaluate the ability of confocal scanning laser tomography of the optic nerve head to detect glaucomatous optic nerve damage in ocular hypertensive eyes without visual field defects. METHODS The study included 50 normal subjects, 61 glaucoma patients with glaucomatous changes in the optic disc and visual field, and 102 “preperimetric” patients with increased intraocular pressure, normal visual fields, and glaucomatous appearance of the optic disc as evaluated on colour stereo optic disc photographs. For all individuals, confocal scanning laser tomographs of the optic nerve head were taken using the Heidelberg retina tomograph (HRT; software 2.01). RESULTS Almost all investigated HRT variables varied significantly (p<0.05) between the normal eyes and preperimetric glaucoma eyes with pronounced overlap between the two study groups. Corresponding to the overlap, sensitivity and specificity values were relatively low when HRT variables were taken to differentiate between normal and preperimetric glaucoma eyes. At a given specificity of 95% highest sensitivities were found for the variables “rim area in the superior disc sector” (24.8%), “nerve fibre layer thickness in the inferior disc sector” (26.5%), and “rim volume in the superior disc sector” (25.5%). A multivariate approach increased sensitivity to 42.2% at a given specificity of 95%. For the glaucoma group highest sensitivity values were reached by rim volume in the superior disc sector (73.8%) and rim area (72.1%); the multivariate approach reached 83.6%. CONCLUSIONS Owing to pronounced overlapping between the groups, confocal scanning laser tomography of the optic nerve head has relatively low diagnostic power to differentiate between normal eyes and preperimetric glaucoma eyes. One of the reasons may be the biological interindividual variability of quantitative optic disc variables.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>confocal scanning laser tomography</subject><subject>Cross-Sectional Studies</subject><subject>Defects</subject><subject>Discriminant analysis</subject><subject>Glaucoma</subject><subject>Glaucoma, Open-Angle - diagnosis</subject><subject>Glaucoma, Open-Angle - physiopathology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lasers</subject><subject>Medical sciences</subject><subject>Microscopy, Confocal</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Multivariate analysis</subject><subject>Nerve Fibers - pathology</subject><subject>optic disc</subject><subject>Optic Disk - pathology</subject><subject>Optic nerve</subject><subject>Original</subject><subject>Otorhinolaryngology. Stomatology. Orbit</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Retina</subject><subject>Retina - pathology</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Software</subject><subject>Studies</subject><subject>Tomography</subject><subject>Variables</subject><subject>Visual Field Tests</subject><subject>Visual Fields</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc2L1DAYh4Mo7uzqzbMEFL3YMR9Nk1wEKe4oLn7AInsLSZrOdGyTbtIuzn9vlg7r6sFDCOF9ePi9-QHwDKM1xrR6a_ZhLeiaromUD8AKl5UoCOLyIVghhHiBcYVPwGlK-_wkFeaPwQlGtGKI8hW4-hbd6GI3uCl2Fm57PdswaNh0eutD6hI0B2iDb4PVPUxWe9_5Lex1chFOYQjbqMfdAYYWTjsHwzhlS9Ml-wQ8anWf3NPjfQYuzz9c1h-Li6-bT_X7i8IwxKfCtQZjZBjjkpeIWa5NKyXDomwEQxVvkLDIUMNFIzFmjlPJKq5pY0mDsKRn4N2iHWczuMY6P0XdqzFvpONBBd2pvye-26ltuFGYEyIFzoJXR0EM17NLkxpyetf32rswJ1VJQQjHJIMv_gH3YY4-75ZdXOZTyjJTbxbKxpBSdO1dFIzUbV8q96UEVVTlvjL-_H78e_BSUAZeHgGdP79vo_a2S384TjATt-GKBevS5H7djXX8qSpOOVNfftTq6vP5ZlPLWn3P_OuFN8P-_wl_A4A1uhg</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>Mardin, Christian Y</creator><creator>Horn, Folkert K</creator><creator>Jonas, Jost B</creator><creator>Budde, Wido M</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19990301</creationdate><title>Preperimetric glaucoma diagnosis by confocal scanning laser tomography of the optic disc</title><author>Mardin, Christian Y ; Horn, Folkert K ; Jonas, Jost B ; Budde, Wido M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b507t-efb110b55797405c7abf995184d85067d08c0b3b78d9115e739567a3dc2d0193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>confocal scanning laser tomography</topic><topic>Cross-Sectional Studies</topic><topic>Defects</topic><topic>Discriminant analysis</topic><topic>Glaucoma</topic><topic>Glaucoma, Open-Angle - diagnosis</topic><topic>Glaucoma, Open-Angle - physiopathology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lasers</topic><topic>Medical sciences</topic><topic>Microscopy, Confocal</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>Multivariate analysis</topic><topic>Nerve Fibers - pathology</topic><topic>optic disc</topic><topic>Optic Disk - pathology</topic><topic>Optic nerve</topic><topic>Original</topic><topic>Otorhinolaryngology. Stomatology. Orbit</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Retina</topic><topic>Retina - pathology</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Software</topic><topic>Studies</topic><topic>Tomography</topic><topic>Variables</topic><topic>Visual Field Tests</topic><topic>Visual Fields</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mardin, Christian Y</creatorcontrib><creatorcontrib>Horn, Folkert K</creatorcontrib><creatorcontrib>Jonas, Jost B</creatorcontrib><creatorcontrib>Budde, Wido M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mardin, Christian Y</au><au>Horn, Folkert K</au><au>Jonas, Jost B</au><au>Budde, Wido M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preperimetric glaucoma diagnosis by confocal scanning laser tomography of the optic disc</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>83</volume><issue>3</issue><spage>299</spage><epage>304</epage><pages>299-304</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>AIM To evaluate the ability of confocal scanning laser tomography of the optic nerve head to detect glaucomatous optic nerve damage in ocular hypertensive eyes without visual field defects. METHODS The study included 50 normal subjects, 61 glaucoma patients with glaucomatous changes in the optic disc and visual field, and 102 “preperimetric” patients with increased intraocular pressure, normal visual fields, and glaucomatous appearance of the optic disc as evaluated on colour stereo optic disc photographs. For all individuals, confocal scanning laser tomographs of the optic nerve head were taken using the Heidelberg retina tomograph (HRT; software 2.01). RESULTS Almost all investigated HRT variables varied significantly (p<0.05) between the normal eyes and preperimetric glaucoma eyes with pronounced overlap between the two study groups. Corresponding to the overlap, sensitivity and specificity values were relatively low when HRT variables were taken to differentiate between normal and preperimetric glaucoma eyes. At a given specificity of 95% highest sensitivities were found for the variables “rim area in the superior disc sector” (24.8%), “nerve fibre layer thickness in the inferior disc sector” (26.5%), and “rim volume in the superior disc sector” (25.5%). A multivariate approach increased sensitivity to 42.2% at a given specificity of 95%. For the glaucoma group highest sensitivity values were reached by rim volume in the superior disc sector (73.8%) and rim area (72.1%); the multivariate approach reached 83.6%. CONCLUSIONS Owing to pronounced overlapping between the groups, confocal scanning laser tomography of the optic nerve head has relatively low diagnostic power to differentiate between normal eyes and preperimetric glaucoma eyes. One of the reasons may be the biological interindividual variability of quantitative optic disc variables.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>10365037</pmid><doi>10.1136/bjo.83.3.299</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Biological and medical sciences confocal scanning laser tomography Cross-Sectional Studies Defects Discriminant analysis Glaucoma Glaucoma, Open-Angle - diagnosis Glaucoma, Open-Angle - physiopathology Humans Investigative techniques, diagnostic techniques (general aspects) Lasers Medical sciences Microscopy, Confocal Middle Aged Morphology Multivariate analysis Nerve Fibers - pathology optic disc Optic Disk - pathology Optic nerve Original Otorhinolaryngology. Stomatology. Orbit Radiodiagnosis. Nmr imagery. Nmr spectrometry Retina Retina - pathology ROC Curve Sensitivity and Specificity Software Studies Tomography Variables Visual Field Tests Visual Fields |
| title | Preperimetric glaucoma diagnosis by confocal scanning laser tomography of the optic disc |
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