Pulsatile ocular blood flow investigation in asymmetric normal tension glaucoma and normal subjects
AIMS This study was designed to investigate pulsatile ocular blood flow (POBF) in normal tension glaucoma (NTG) patients and in normal controls. NTG patients with unilateral field loss were evaluated to compare POBF values between eyes with and without field loss. METHODS POBF measurements from more...
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| Veröffentlicht in: | British journal of ophthalmology 1998-07, Vol.82 (7), p.731-736 |
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| creator | Fontana, Luigi Poinoosawmy, Darmalingum Bunce, Catey V O’Brien, Colm Hitchings, Roger A |
| description | AIMS This study was designed to investigate pulsatile ocular blood flow (POBF) in normal tension glaucoma (NTG) patients and in normal controls. NTG patients with unilateral field loss were evaluated to compare POBF values between eyes with and without field loss. METHODS POBF measurements from more than 1500 subjects were collected during a period of 6 months from six optometric centres. Subjects with systemic vascular diseases (such as systemic hypertension and diabetes), ophthalmic diseases, a positive family history of glaucoma, and those individuals receiving treatment with systemic β blockers were excluded on the basis of a questionnaire. For comparison, 95 NTG patients with unilateral field loss, selected from 403 consecutive patients with NTG, underwent POBF testing. For each individual age, sex, intraocular pressure, refraction, and pulse rate were entered into a database. RESULTS Data from 777 subjects were included in the analysis. POBF measurements of patients and subjects were compared allowing for differences in age, sex, intraocular pressure, refraction, and pulse rate. POBF was significantly lower in eyes of NTG patients with and without field loss (p |
| doi_str_mv | 10.1136/bjo.82.7.731 |
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NTG patients with unilateral field loss were evaluated to compare POBF values between eyes with and without field loss. METHODS POBF measurements from more than 1500 subjects were collected during a period of 6 months from six optometric centres. Subjects with systemic vascular diseases (such as systemic hypertension and diabetes), ophthalmic diseases, a positive family history of glaucoma, and those individuals receiving treatment with systemic β blockers were excluded on the basis of a questionnaire. For comparison, 95 NTG patients with unilateral field loss, selected from 403 consecutive patients with NTG, underwent POBF testing. For each individual age, sex, intraocular pressure, refraction, and pulse rate were entered into a database. RESULTS Data from 777 subjects were included in the analysis. POBF measurements of patients and subjects were compared allowing for differences in age, sex, intraocular pressure, refraction, and pulse rate. POBF was significantly lower in eyes of NTG patients with and without field loss (p <0.001 and p = 0.01 respectively). Eyes of NTG patients with field loss showed significantly lower POBF than the contralateral eyes with normal field (p < 0.001). CONCLUSIONS POBF was significantly lower in eyes of NTG patients with and without field loss than in normal subjects, suggesting that differences in ocular blood perfusion are relevant to the development of NTG and are detectable from the early stage of the disease. Furthermore, the finding of lower POBF in NTG eyes with field loss than in the contralateral eyes with normal field suggests that haemodynamic differences between fellow eyes contribute to determine the side of onset of the disease.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.82.7.731</identifier><identifier>PMID: 9924361</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Adolescent ; Adult ; Age ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Child ; Disease ; Eye - blood supply ; Family medical history ; Female ; Glaucoma ; Glaucoma - physiopathology ; Glaucoma and intraocular pressure ; Hospitals ; Humans ; Hypertension ; Male ; Medical sciences ; Middle Aged ; normal tension glaucoma ; Ophthalmology ; Optic nerve ; Original articles - Clinical science ; Pathogenesis ; Pulsatile Flow ; pulsatile ocular blood flow ; Refraction, Ocular ; Software ; Studies ; Visual Acuity ; visual field asymmetry</subject><ispartof>British journal of ophthalmology, 1998-07, Vol.82 (7), p.731-736</ispartof><rights>British Journal of Ophthalmology</rights><rights>1998 INIST-CNRS</rights><rights>Copyright: 1998 British Journal of Ophthalmology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b549t-79c32c95f46ca200d1982d4b193878ccd47d26edd84153e628ff0ba4aa764c8e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1722652/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1722652/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2335638$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9924361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fontana, Luigi</creatorcontrib><creatorcontrib>Poinoosawmy, Darmalingum</creatorcontrib><creatorcontrib>Bunce, Catey V</creatorcontrib><creatorcontrib>O’Brien, Colm</creatorcontrib><creatorcontrib>Hitchings, Roger A</creatorcontrib><title>Pulsatile ocular blood flow investigation in asymmetric normal tension glaucoma and normal subjects</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>AIMS This study was designed to investigate pulsatile ocular blood flow (POBF) in normal tension glaucoma (NTG) patients and in normal controls. NTG patients with unilateral field loss were evaluated to compare POBF values between eyes with and without field loss. METHODS POBF measurements from more than 1500 subjects were collected during a period of 6 months from six optometric centres. Subjects with systemic vascular diseases (such as systemic hypertension and diabetes), ophthalmic diseases, a positive family history of glaucoma, and those individuals receiving treatment with systemic β blockers were excluded on the basis of a questionnaire. For comparison, 95 NTG patients with unilateral field loss, selected from 403 consecutive patients with NTG, underwent POBF testing. For each individual age, sex, intraocular pressure, refraction, and pulse rate were entered into a database. RESULTS Data from 777 subjects were included in the analysis. POBF measurements of patients and subjects were compared allowing for differences in age, sex, intraocular pressure, refraction, and pulse rate. POBF was significantly lower in eyes of NTG patients with and without field loss (p <0.001 and p = 0.01 respectively). Eyes of NTG patients with field loss showed significantly lower POBF than the contralateral eyes with normal field (p < 0.001). CONCLUSIONS POBF was significantly lower in eyes of NTG patients with and without field loss than in normal subjects, suggesting that differences in ocular blood perfusion are relevant to the development of NTG and are detectable from the early stage of the disease. Furthermore, the finding of lower POBF in NTG eyes with field loss than in the contralateral eyes with normal field suggests that haemodynamic differences between fellow eyes contribute to determine the side of onset of the disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Disease</subject><subject>Eye - blood supply</subject><subject>Family medical history</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Glaucoma - physiopathology</subject><subject>Glaucoma and intraocular pressure</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>normal tension glaucoma</subject><subject>Ophthalmology</subject><subject>Optic nerve</subject><subject>Original articles - Clinical science</subject><subject>Pathogenesis</subject><subject>Pulsatile Flow</subject><subject>pulsatile ocular blood flow</subject><subject>Refraction, Ocular</subject><subject>Software</subject><subject>Studies</subject><subject>Visual Acuity</subject><subject>visual field asymmetry</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU2LFDEQhhtR1nH15lVoUPRij_nqfFwEGVwVB_WwusdQnU6PadPJmnSv7r83y4yDevBUFM_DSxVvVT3EaI0x5S-6Ma4lWYu1oPhWtcKMy4YgoW5XK4SQaDDm-G51L-exrIRjcVKdKEUY5XhVmU-LzzA7b-toFg-p7nyMfT34-KN24crm2e0Kj6FsNeTrabJzcqYOMU3g69mGfAN3HhYTJ6gh9L9ZXrrRmjnfr-4M4LN9cJin1eez1-ebt83245t3m1fbpmuZmhuhDCVGtQPjBghCPVaS9KzDikohjemZ6Am3fS8ZbqnlRA4D6oABCM6MtPS0ernPvVy6yfbGhjmB15fJTZCudQSn_ybBfdW7eKWxIIS3pAQ8PQSk-H0pr-vJZWO9h2DjkjVXmCPBUBEf_yOOcUmhPFeyhFSccsSK9XxvmRRzTnY4noKRvqlOl-q0JFroUl3RH_15_lE-dFX4kwOHbMAPCYJx-agRSltOZdGavebybH8eMaRvmgsqWv3hy0bzrTy7eH9-oXnxn-39bhr_f-AvtkW_ew</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Fontana, Luigi</creator><creator>Poinoosawmy, Darmalingum</creator><creator>Bunce, Catey V</creator><creator>O’Brien, Colm</creator><creator>Hitchings, Roger A</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19980701</creationdate><title>Pulsatile ocular blood flow investigation in asymmetric normal tension glaucoma and normal subjects</title><author>Fontana, Luigi ; Poinoosawmy, Darmalingum ; Bunce, Catey V ; O’Brien, Colm ; Hitchings, Roger A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b549t-79c32c95f46ca200d1982d4b193878ccd47d26edd84153e628ff0ba4aa764c8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Disease</topic><topic>Eye - blood supply</topic><topic>Family medical history</topic><topic>Female</topic><topic>Glaucoma</topic><topic>Glaucoma - physiopathology</topic><topic>Glaucoma and intraocular pressure</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>normal tension glaucoma</topic><topic>Ophthalmology</topic><topic>Optic nerve</topic><topic>Original articles - Clinical science</topic><topic>Pathogenesis</topic><topic>Pulsatile Flow</topic><topic>pulsatile ocular blood flow</topic><topic>Refraction, Ocular</topic><topic>Software</topic><topic>Studies</topic><topic>Visual Acuity</topic><topic>visual field asymmetry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fontana, Luigi</creatorcontrib><creatorcontrib>Poinoosawmy, Darmalingum</creatorcontrib><creatorcontrib>Bunce, Catey V</creatorcontrib><creatorcontrib>O’Brien, Colm</creatorcontrib><creatorcontrib>Hitchings, Roger A</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fontana, Luigi</au><au>Poinoosawmy, Darmalingum</au><au>Bunce, Catey V</au><au>O’Brien, Colm</au><au>Hitchings, Roger A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulsatile ocular blood flow investigation in asymmetric normal tension glaucoma and normal subjects</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>82</volume><issue>7</issue><spage>731</spage><epage>736</epage><pages>731-736</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>AIMS This study was designed to investigate pulsatile ocular blood flow (POBF) in normal tension glaucoma (NTG) patients and in normal controls. NTG patients with unilateral field loss were evaluated to compare POBF values between eyes with and without field loss. METHODS POBF measurements from more than 1500 subjects were collected during a period of 6 months from six optometric centres. Subjects with systemic vascular diseases (such as systemic hypertension and diabetes), ophthalmic diseases, a positive family history of glaucoma, and those individuals receiving treatment with systemic β blockers were excluded on the basis of a questionnaire. For comparison, 95 NTG patients with unilateral field loss, selected from 403 consecutive patients with NTG, underwent POBF testing. For each individual age, sex, intraocular pressure, refraction, and pulse rate were entered into a database. RESULTS Data from 777 subjects were included in the analysis. POBF measurements of patients and subjects were compared allowing for differences in age, sex, intraocular pressure, refraction, and pulse rate. POBF was significantly lower in eyes of NTG patients with and without field loss (p <0.001 and p = 0.01 respectively). Eyes of NTG patients with field loss showed significantly lower POBF than the contralateral eyes with normal field (p < 0.001). CONCLUSIONS POBF was significantly lower in eyes of NTG patients with and without field loss than in normal subjects, suggesting that differences in ocular blood perfusion are relevant to the development of NTG and are detectable from the early stage of the disease. Furthermore, the finding of lower POBF in NTG eyes with field loss than in the contralateral eyes with normal field suggests that haemodynamic differences between fellow eyes contribute to determine the side of onset of the disease.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>9924361</pmid><doi>10.1136/bjo.82.7.731</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Aged Aged, 80 and over Biological and medical sciences Child Disease Eye - blood supply Family medical history Female Glaucoma Glaucoma - physiopathology Glaucoma and intraocular pressure Hospitals Humans Hypertension Male Medical sciences Middle Aged normal tension glaucoma Ophthalmology Optic nerve Original articles - Clinical science Pathogenesis Pulsatile Flow pulsatile ocular blood flow Refraction, Ocular Software Studies Visual Acuity visual field asymmetry |
| title | Pulsatile ocular blood flow investigation in asymmetric normal tension glaucoma and normal subjects |
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