Clinical results of implantation of the Chirila keratoprosthesis in rabbits
AIMS/BACKGROUND An ideal keratoprosthesis (KPro) would closely resemble a donor corneal button in terms of its surgical handling, optics, and capacity to heal with host tissue in order to avoid many of the complications associated with the KPros which are currently in clinical use. This study was ca...
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| Veröffentlicht in: | British journal of ophthalmology 1998-01, Vol.82 (1), p.18-25 |
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| creator | Hicks, Celia R Chirila, Traian V Clayton, Anthony B Fitton, J Helen Vijayasekaran, Sarojini Dalton, Paul D Lou, Xia Platten, Sharon Ziegelaar, Brian Hong, Ye Crawford, Geoffrey J Constable, Ian J |
| description | AIMS/BACKGROUND An ideal keratoprosthesis (KPro) would closely resemble a donor corneal button in terms of its surgical handling, optics, and capacity to heal with host tissue in order to avoid many of the complications associated with the KPros which are currently in clinical use. This study was carried out to assess the long term clinical outcomes on implantation of the core and skirt poly(2-hydroxyethyl methacrylate) KPro in animals. METHODS 20 KPros were made and implanted as full thickness corneal replacements into rabbits and followed for up to 21 months to date. RESULTS 80% of the prostheses have been retained, with a low incidence of complications such as cataract, glaucoma, and retroprosthetic membrane formation which are frequently associated with KPro surgery. CONCLUSIONS KPros of this type may offer promise in the treatment of patients for whom penetrating keratoplasty with donor material carries a poor prognosis. Refinement of the KPro and further animal trials, including implantation into abnormal corneas, are however mandatory before human implantation could be planned. |
| doi_str_mv | 10.1136/bjo.82.1.18 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1722337</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79779582</sourcerecordid><originalsourceid>FETCH-LOGICAL-b466t-7fdf3c2a07f7f01f4996d19f03e4a2172655919f89508c980e1f766e7f2445663</originalsourceid><addsrcrecordid>eNp9kUtLxDAUhYMoOj5WroWC4kY65qZtHhtBBl8ouNF1SDuJk7FtxiQV_PdmcBgfC1fh5B6-3JOD0CHgMUBBz-u5G3MyhjHwDTSCkvKcYCY20QhjzHIACjtoN4R5koQC20bboiooZ-UI3U9a29tGtZnXYWhjyJzJbLdoVR9VtK5f6jjT2WRmvW1V9qq9im7hXUi3wYbM9plXdW1j2EdbRrVBH6zOPfR8ffU0uc0fHm_uJpcPeV1SGnNmpqZoiMLMMIPBlELQKQiDC10qAozQqhJJc1Fh3giONRhGqWaGlGVFabGHLr64i6Hu9LTRffSqlQtvO-U_pFNW_p70diZf3LtMbFIULAFOVwDv3gYdouxsaHSbQms3BMkEY6LiJBmP_xjnbvB9CpdYjIuiFLDEnX25mvQrwWuzXgWwXDYkU0OSEwkSeHIf_dx-7V1VkuYnq7kKqRfjVd_YsLYRLFiifGeou_m_730Cn-OlUg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1778934917</pqid></control><display><type>article</type><title>Clinical results of implantation of the Chirila keratoprosthesis in rabbits</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Hicks, Celia R ; Chirila, Traian V ; Clayton, Anthony B ; Fitton, J Helen ; Vijayasekaran, Sarojini ; Dalton, Paul D ; Lou, Xia ; Platten, Sharon ; Ziegelaar, Brian ; Hong, Ye ; Crawford, Geoffrey J ; Constable, Ian J</creator><creatorcontrib>Hicks, Celia R ; Chirila, Traian V ; Clayton, Anthony B ; Fitton, J Helen ; Vijayasekaran, Sarojini ; Dalton, Paul D ; Lou, Xia ; Platten, Sharon ; Ziegelaar, Brian ; Hong, Ye ; Crawford, Geoffrey J ; Constable, Ian J</creatorcontrib><description>AIMS/BACKGROUND An ideal keratoprosthesis (KPro) would closely resemble a donor corneal button in terms of its surgical handling, optics, and capacity to heal with host tissue in order to avoid many of the complications associated with the KPros which are currently in clinical use. This study was carried out to assess the long term clinical outcomes on implantation of the core and skirt poly(2-hydroxyethyl methacrylate) KPro in animals. METHODS 20 KPros were made and implanted as full thickness corneal replacements into rabbits and followed for up to 21 months to date. RESULTS 80% of the prostheses have been retained, with a low incidence of complications such as cataract, glaucoma, and retroprosthetic membrane formation which are frequently associated with KPro surgery. CONCLUSIONS KPros of this type may offer promise in the treatment of patients for whom penetrating keratoplasty with donor material carries a poor prognosis. Refinement of the KPro and further animal trials, including implantation into abnormal corneas, are however mandatory before human implantation could be planned.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.82.1.18</identifier><identifier>PMID: 9536874</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>London: BMJ</publisher><subject>Animals ; Biological and medical sciences ; Bioprosthesis ; Cell adhesion & migration ; Cornea - surgery ; Intraoperative Complications ; Medical sciences ; Optics ; Original articles - Clinical science ; Polyhydroxyethyl Methacrylate ; Postoperative period ; Prosthesis Failure ; Prosthesis Fitting - methods ; Rabbits ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the eye and orbit ; Surgical Wound Dehiscence ; Transplants & implants ; Treatment Outcome</subject><ispartof>British journal of ophthalmology, 1998-01, Vol.82 (1), p.18-25</ispartof><rights>British Journal of Ophthalmology</rights><rights>1998 INIST-CNRS</rights><rights>Copyright: 1998 British Journal of Ophthalmology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b466t-7fdf3c2a07f7f01f4996d19f03e4a2172655919f89508c980e1f766e7f2445663</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1722337/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1722337/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2097183$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9536874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hicks, Celia R</creatorcontrib><creatorcontrib>Chirila, Traian V</creatorcontrib><creatorcontrib>Clayton, Anthony B</creatorcontrib><creatorcontrib>Fitton, J Helen</creatorcontrib><creatorcontrib>Vijayasekaran, Sarojini</creatorcontrib><creatorcontrib>Dalton, Paul D</creatorcontrib><creatorcontrib>Lou, Xia</creatorcontrib><creatorcontrib>Platten, Sharon</creatorcontrib><creatorcontrib>Ziegelaar, Brian</creatorcontrib><creatorcontrib>Hong, Ye</creatorcontrib><creatorcontrib>Crawford, Geoffrey J</creatorcontrib><creatorcontrib>Constable, Ian J</creatorcontrib><title>Clinical results of implantation of the Chirila keratoprosthesis in rabbits</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>AIMS/BACKGROUND An ideal keratoprosthesis (KPro) would closely resemble a donor corneal button in terms of its surgical handling, optics, and capacity to heal with host tissue in order to avoid many of the complications associated with the KPros which are currently in clinical use. This study was carried out to assess the long term clinical outcomes on implantation of the core and skirt poly(2-hydroxyethyl methacrylate) KPro in animals. METHODS 20 KPros were made and implanted as full thickness corneal replacements into rabbits and followed for up to 21 months to date. RESULTS 80% of the prostheses have been retained, with a low incidence of complications such as cataract, glaucoma, and retroprosthetic membrane formation which are frequently associated with KPro surgery. CONCLUSIONS KPros of this type may offer promise in the treatment of patients for whom penetrating keratoplasty with donor material carries a poor prognosis. Refinement of the KPro and further animal trials, including implantation into abnormal corneas, are however mandatory before human implantation could be planned.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bioprosthesis</subject><subject>Cell adhesion & migration</subject><subject>Cornea - surgery</subject><subject>Intraoperative Complications</subject><subject>Medical sciences</subject><subject>Optics</subject><subject>Original articles - Clinical science</subject><subject>Polyhydroxyethyl Methacrylate</subject><subject>Postoperative period</subject><subject>Prosthesis Failure</subject><subject>Prosthesis Fitting - methods</subject><subject>Rabbits</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the eye and orbit</subject><subject>Surgical Wound Dehiscence</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtLxDAUhYMoOj5WroWC4kY65qZtHhtBBl8ouNF1SDuJk7FtxiQV_PdmcBgfC1fh5B6-3JOD0CHgMUBBz-u5G3MyhjHwDTSCkvKcYCY20QhjzHIACjtoN4R5koQC20bboiooZ-UI3U9a29tGtZnXYWhjyJzJbLdoVR9VtK5f6jjT2WRmvW1V9qq9im7hXUi3wYbM9plXdW1j2EdbRrVBH6zOPfR8ffU0uc0fHm_uJpcPeV1SGnNmpqZoiMLMMIPBlELQKQiDC10qAozQqhJJc1Fh3giONRhGqWaGlGVFabGHLr64i6Hu9LTRffSqlQtvO-U_pFNW_p70diZf3LtMbFIULAFOVwDv3gYdouxsaHSbQms3BMkEY6LiJBmP_xjnbvB9CpdYjIuiFLDEnX25mvQrwWuzXgWwXDYkU0OSEwkSeHIf_dx-7V1VkuYnq7kKqRfjVd_YsLYRLFiifGeou_m_730Cn-OlUg</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Hicks, Celia R</creator><creator>Chirila, Traian V</creator><creator>Clayton, Anthony B</creator><creator>Fitton, J Helen</creator><creator>Vijayasekaran, Sarojini</creator><creator>Dalton, Paul D</creator><creator>Lou, Xia</creator><creator>Platten, Sharon</creator><creator>Ziegelaar, Brian</creator><creator>Hong, Ye</creator><creator>Crawford, Geoffrey J</creator><creator>Constable, Ian J</creator><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199801</creationdate><title>Clinical results of implantation of the Chirila keratoprosthesis in rabbits</title><author>Hicks, Celia R ; Chirila, Traian V ; Clayton, Anthony B ; Fitton, J Helen ; Vijayasekaran, Sarojini ; Dalton, Paul D ; Lou, Xia ; Platten, Sharon ; Ziegelaar, Brian ; Hong, Ye ; Crawford, Geoffrey J ; Constable, Ian J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b466t-7fdf3c2a07f7f01f4996d19f03e4a2172655919f89508c980e1f766e7f2445663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bioprosthesis</topic><topic>Cell adhesion & migration</topic><topic>Cornea - surgery</topic><topic>Intraoperative Complications</topic><topic>Medical sciences</topic><topic>Optics</topic><topic>Original articles - Clinical science</topic><topic>Polyhydroxyethyl Methacrylate</topic><topic>Postoperative period</topic><topic>Prosthesis Failure</topic><topic>Prosthesis Fitting - methods</topic><topic>Rabbits</topic><topic>Surgery</topic><topic>Surgery (general aspects). 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Graft diseases</topic><topic>Surgery of the eye and orbit</topic><topic>Surgical Wound Dehiscence</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hicks, Celia R</creatorcontrib><creatorcontrib>Chirila, Traian V</creatorcontrib><creatorcontrib>Clayton, Anthony B</creatorcontrib><creatorcontrib>Fitton, J Helen</creatorcontrib><creatorcontrib>Vijayasekaran, Sarojini</creatorcontrib><creatorcontrib>Dalton, Paul D</creatorcontrib><creatorcontrib>Lou, Xia</creatorcontrib><creatorcontrib>Platten, Sharon</creatorcontrib><creatorcontrib>Ziegelaar, Brian</creatorcontrib><creatorcontrib>Hong, Ye</creatorcontrib><creatorcontrib>Crawford, Geoffrey J</creatorcontrib><creatorcontrib>Constable, Ian J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hicks, Celia R</au><au>Chirila, Traian V</au><au>Clayton, Anthony B</au><au>Fitton, J Helen</au><au>Vijayasekaran, Sarojini</au><au>Dalton, Paul D</au><au>Lou, Xia</au><au>Platten, Sharon</au><au>Ziegelaar, Brian</au><au>Hong, Ye</au><au>Crawford, Geoffrey J</au><au>Constable, Ian J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical results of implantation of the Chirila keratoprosthesis in rabbits</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>1998-01</date><risdate>1998</risdate><volume>82</volume><issue>1</issue><spage>18</spage><epage>25</epage><pages>18-25</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>AIMS/BACKGROUND An ideal keratoprosthesis (KPro) would closely resemble a donor corneal button in terms of its surgical handling, optics, and capacity to heal with host tissue in order to avoid many of the complications associated with the KPros which are currently in clinical use. This study was carried out to assess the long term clinical outcomes on implantation of the core and skirt poly(2-hydroxyethyl methacrylate) KPro in animals. METHODS 20 KPros were made and implanted as full thickness corneal replacements into rabbits and followed for up to 21 months to date. RESULTS 80% of the prostheses have been retained, with a low incidence of complications such as cataract, glaucoma, and retroprosthetic membrane formation which are frequently associated with KPro surgery. CONCLUSIONS KPros of this type may offer promise in the treatment of patients for whom penetrating keratoplasty with donor material carries a poor prognosis. Refinement of the KPro and further animal trials, including implantation into abnormal corneas, are however mandatory before human implantation could be planned.</abstract><cop>London</cop><pub>BMJ</pub><pmid>9536874</pmid><doi>10.1136/bjo.82.1.18</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Bioprosthesis Cell adhesion & migration Cornea - surgery Intraoperative Complications Medical sciences Optics Original articles - Clinical science Polyhydroxyethyl Methacrylate Postoperative period Prosthesis Failure Prosthesis Fitting - methods Rabbits Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit Surgical Wound Dehiscence Transplants & implants Treatment Outcome |
| title | Clinical results of implantation of the Chirila keratoprosthesis in rabbits |
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