Concentrations of cardiac troponin T in neonates with and without respiratory distress
Aims: To establish a practical postnatal reference range for cardiac troponin T in neonates and to investigate concentrations in neonates with respiratory distress. Methods: Prospective investigation in a tertiary neonatal unit, recruiting infants with and without respiratory distress (sick and heal...
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| Veröffentlicht in: | Archives of disease in childhood. Fetal and neonatal edition 2004-07, Vol.89 (4), p.F348-F352 |
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| container_title | Archives of disease in childhood. Fetal and neonatal edition |
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| creator | Clark, S Newland, P Yoxall, C W Subhedar, N V |
| description | Aims: To establish a practical postnatal reference range for cardiac troponin T in neonates and to investigate concentrations in neonates with respiratory distress. Methods: Prospective investigation in a tertiary neonatal unit, recruiting infants with and without respiratory distress (sick and healthy infants respectively). Concentrations of cardiac troponin T were compared between sick and healthy infants, accounting for confounding variables. Results: A total of 162 neonates (113 healthy and 49 sick infants) had samples taken. The median (interquartile range) cardiac troponin T concentration in the healthy infants was 0.025 (0.01–0.062) ng/ml, and the 95th centile was 0.153 ng/ml. There were no significant relations between cardiac troponin T and various variables. The median (interquartile range) cardiac troponin T concentration in the sick infants was 0.159 (0.075–0.308) ng/ml. This was significantly higher (p |
| doi_str_mv | 10.1136/adc.2002.025478 |
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Methods: Prospective investigation in a tertiary neonatal unit, recruiting infants with and without respiratory distress (sick and healthy infants respectively). Concentrations of cardiac troponin T were compared between sick and healthy infants, accounting for confounding variables. Results: A total of 162 neonates (113 healthy and 49 sick infants) had samples taken. The median (interquartile range) cardiac troponin T concentration in the healthy infants was 0.025 (0.01–0.062) ng/ml, and the 95th centile was 0.153 ng/ml. There were no significant relations between cardiac troponin T and various variables. The median (interquartile range) cardiac troponin T concentration in the sick infants was 0.159 (0.075–0.308) ng/ml. This was significantly higher (p < 0.0001) than in the healthy infants. In a linear regression model, the use of inotropes and oxygen requirement were significant associations independent of other basic and clinical variables in explaining the variation in cardiac troponin T concentrations. Conclusions: Cardiac troponin T is detectable in the blood of many healthy neonates, but no relation with important basic and clinical variables was found. Sick infants have significantly higher concentrations than healthy infants. The variations in cardiac troponin T concentration were significantly associated with oxygen requirement or the use of inotropic support in a regression model. Cardiac troponin T may be a useful marker of neonatal and cardiorespiratory morbidity.</description><identifier>ISSN: 1359-2998</identifier><identifier>EISSN: 1468-2052</identifier><identifier>DOI: 10.1136/adc.2002.025478</identifier><identifier>PMID: 15210673</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Babies ; Birth weight ; cardiac troponin T ; Clinical outcomes ; Female ; Gangrene ; Heart attacks ; Humans ; Infant, Newborn ; Infants ; Male ; Mortality ; Neonates ; Original ; Oxygen requirement ; Preeclampsia ; Prospective Studies ; Recruitment ; Reference Standards ; Respiratory distress syndrome ; Respiratory Distress Syndrome, Newborn - blood ; Statistical analysis ; Statistics, Nonparametric ; Studies ; Troponin T - blood ; Ventilation ; Womens health</subject><ispartof>Archives of disease in childhood. Fetal and neonatal edition, 2004-07, Vol.89 (4), p.F348-F352</ispartof><rights>Copyright 2004 Archives of Disease in Childhood</rights><rights>Copyright: 2004 Copyright 2004 Archives of Disease in Childhood</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b490t-d537adc3a582500d1c6829c1593e285a302afcb181b27e277b0b934706079dd23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721706/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721706/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15210673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Clark, S</creatorcontrib><creatorcontrib>Newland, P</creatorcontrib><creatorcontrib>Yoxall, C W</creatorcontrib><creatorcontrib>Subhedar, N V</creatorcontrib><title>Concentrations of cardiac troponin T in neonates with and without respiratory distress</title><title>Archives of disease in childhood. Fetal and neonatal edition</title><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><description>Aims: To establish a practical postnatal reference range for cardiac troponin T in neonates and to investigate concentrations in neonates with respiratory distress. Methods: Prospective investigation in a tertiary neonatal unit, recruiting infants with and without respiratory distress (sick and healthy infants respectively). Concentrations of cardiac troponin T were compared between sick and healthy infants, accounting for confounding variables. Results: A total of 162 neonates (113 healthy and 49 sick infants) had samples taken. The median (interquartile range) cardiac troponin T concentration in the healthy infants was 0.025 (0.01–0.062) ng/ml, and the 95th centile was 0.153 ng/ml. There were no significant relations between cardiac troponin T and various variables. The median (interquartile range) cardiac troponin T concentration in the sick infants was 0.159 (0.075–0.308) ng/ml. This was significantly higher (p < 0.0001) than in the healthy infants. In a linear regression model, the use of inotropes and oxygen requirement were significant associations independent of other basic and clinical variables in explaining the variation in cardiac troponin T concentrations. Conclusions: Cardiac troponin T is detectable in the blood of many healthy neonates, but no relation with important basic and clinical variables was found. Sick infants have significantly higher concentrations than healthy infants. The variations in cardiac troponin T concentration were significantly associated with oxygen requirement or the use of inotropic support in a regression model. Cardiac troponin T may be a useful marker of neonatal and cardiorespiratory morbidity.</description><subject>Babies</subject><subject>Birth weight</subject><subject>cardiac troponin T</subject><subject>Clinical outcomes</subject><subject>Female</subject><subject>Gangrene</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Male</subject><subject>Mortality</subject><subject>Neonates</subject><subject>Original</subject><subject>Oxygen requirement</subject><subject>Preeclampsia</subject><subject>Prospective Studies</subject><subject>Recruitment</subject><subject>Reference Standards</subject><subject>Respiratory distress syndrome</subject><subject>Respiratory Distress Syndrome, Newborn - blood</subject><subject>Statistical analysis</subject><subject>Statistics, Nonparametric</subject><subject>Studies</subject><subject>Troponin T - blood</subject><subject>Ventilation</subject><subject>Womens health</subject><issn>1359-2998</issn><issn>1468-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkT1vFDEQhi0EIiFQ0yFLSBRIe_HHeu1tkNCSACKCJlxBY3ltH_FxZ19sLyH_njn2FD4aGnuseeadeT0IPaVkQSnvTo2zC0YIWxAmWqnuoWPadqphRLD7EHPRN6zv1RF6VMqaEEKllA_RERWMkk7yY7QcUrQ-1mxqSLHgtMLWZBeMxTWnXYoh4ksMR_QpmuoLvgn1CpvofgVpqjj7sgtQn_ItdqFUeJfH6MHKbIp_crhP0Ofzs8vhXXPx6e374fVFM7Y9qY0TXIIFboRighBHbadYb6nouWdKGE6YWdmRKjoy6ZmUIxl73krSEdk7x_gJejXr7qZx693sZKN3OWxNvtXJBP13JoYr_TV911QyCjIg8OIgkNP15EvV21Cs32wMGJ6K7rquhXH2nZ7_A67TlCOYAy1FAGJcAXU6UzanUrJf3Y1Cid5vTINdvd-YnjcGFc_-dPCbP6wIgGYG4Gv9j7u8yd80pKXQH5eD_vJhef5maAdNgX858-N2_d_uPwFo2652</recordid><startdate>200407</startdate><enddate>200407</enddate><creator>Clark, S</creator><creator>Newland, P</creator><creator>Yoxall, C W</creator><creator>Subhedar, N V</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200407</creationdate><title>Concentrations of cardiac troponin T in neonates with and without respiratory distress</title><author>Clark, S ; Newland, P ; Yoxall, C W ; Subhedar, N V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b490t-d537adc3a582500d1c6829c1593e285a302afcb181b27e277b0b934706079dd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Babies</topic><topic>Birth weight</topic><topic>cardiac troponin T</topic><topic>Clinical outcomes</topic><topic>Female</topic><topic>Gangrene</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Male</topic><topic>Mortality</topic><topic>Neonates</topic><topic>Original</topic><topic>Oxygen requirement</topic><topic>Preeclampsia</topic><topic>Prospective Studies</topic><topic>Recruitment</topic><topic>Reference Standards</topic><topic>Respiratory distress syndrome</topic><topic>Respiratory Distress Syndrome, Newborn - blood</topic><topic>Statistical analysis</topic><topic>Statistics, Nonparametric</topic><topic>Studies</topic><topic>Troponin T - blood</topic><topic>Ventilation</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clark, S</creatorcontrib><creatorcontrib>Newland, P</creatorcontrib><creatorcontrib>Yoxall, C W</creatorcontrib><creatorcontrib>Subhedar, N V</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clark, S</au><au>Newland, P</au><au>Yoxall, C W</au><au>Subhedar, N V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concentrations of cardiac troponin T in neonates with and without respiratory distress</atitle><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><date>2004-07</date><risdate>2004</risdate><volume>89</volume><issue>4</issue><spage>F348</spage><epage>F352</epage><pages>F348-F352</pages><issn>1359-2998</issn><eissn>1468-2052</eissn><abstract>Aims: To establish a practical postnatal reference range for cardiac troponin T in neonates and to investigate concentrations in neonates with respiratory distress. Methods: Prospective investigation in a tertiary neonatal unit, recruiting infants with and without respiratory distress (sick and healthy infants respectively). Concentrations of cardiac troponin T were compared between sick and healthy infants, accounting for confounding variables. Results: A total of 162 neonates (113 healthy and 49 sick infants) had samples taken. The median (interquartile range) cardiac troponin T concentration in the healthy infants was 0.025 (0.01–0.062) ng/ml, and the 95th centile was 0.153 ng/ml. There were no significant relations between cardiac troponin T and various variables. The median (interquartile range) cardiac troponin T concentration in the sick infants was 0.159 (0.075–0.308) ng/ml. This was significantly higher (p < 0.0001) than in the healthy infants. In a linear regression model, the use of inotropes and oxygen requirement were significant associations independent of other basic and clinical variables in explaining the variation in cardiac troponin T concentrations. Conclusions: Cardiac troponin T is detectable in the blood of many healthy neonates, but no relation with important basic and clinical variables was found. Sick infants have significantly higher concentrations than healthy infants. The variations in cardiac troponin T concentration were significantly associated with oxygen requirement or the use of inotropic support in a regression model. Cardiac troponin T may be a useful marker of neonatal and cardiorespiratory morbidity.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>15210673</pmid><doi>10.1136/adc.2002.025478</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Babies Birth weight cardiac troponin T Clinical outcomes Female Gangrene Heart attacks Humans Infant, Newborn Infants Male Mortality Neonates Original Oxygen requirement Preeclampsia Prospective Studies Recruitment Reference Standards Respiratory distress syndrome Respiratory Distress Syndrome, Newborn - blood Statistical analysis Statistics, Nonparametric Studies Troponin T - blood Ventilation Womens health |
| title | Concentrations of cardiac troponin T in neonates with and without respiratory distress |
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