The magnetic resonance revolution in brain imaging: impact on neonatal intensive care
Despite these advances, perinatal hypoxia-ischaemia (HI) is experienced by about 4/1000 live term births, and disability rates among very low birthweight (birth weight < 1500 g) infants remain high, with 5-15% showing major spastic abnormalities and an additional 25-50% or more having deficits in...
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| Veröffentlicht in: | Archives of disease in childhood. Fetal and neonatal edition 2004-05, Vol.89 (3), p.F193-F197 |
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| creator | Robertson, N J Wyatt, J S |
| description | Despite these advances, perinatal hypoxia-ischaemia (HI) is experienced by about 4/1000 live term births, and disability rates among very low birthweight (birth weight < 1500 g) infants remain high, with 5-15% showing major spastic abnormalities and an additional 25-50% or more having deficits in cognition and behaviour. 4- 6 Neuroimaging is needed in at risk infants, as clinical evaluation may not provide adequate diagnostic or prognostic information and has two principal functions: (a) early diagnosis of brain injury so that appropriate medical management can be provided; (b) detection of lesions associated with long term neurodevelopmental disability. [...]diffusion weighted imaging has not been proven to be effective as a prognostic tool in NE. 14 This is surprising, as diffusion weighted imaging in the adult brain 15 and experimental models 16 of stroke has revolutionised the possibility of early diagnosis and intervention, often revealing image abnormalities on water diffusion maps well before CT or conventional MR. 31P and 1H MR spectroscopy (giving quantitative information on brain energetics, intracellular pH (pHi) and lactate) can give early prognostic information on brain injury severity. |
| doi_str_mv | 10.1136/adc.2003.027334 |
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[...]diffusion weighted imaging has not been proven to be effective as a prognostic tool in NE. 14 This is surprising, as diffusion weighted imaging in the adult brain 15 and experimental models 16 of stroke has revolutionised the possibility of early diagnosis and intervention, often revealing image abnormalities on water diffusion maps well before CT or conventional MR. 31P and 1H MR spectroscopy (giving quantitative information on brain energetics, intracellular pH (pHi) and lactate) can give early prognostic information on brain injury severity.</description><identifier>ISSN: 1359-2998</identifier><identifier>EISSN: 1468-2052</identifier><identifier>DOI: 10.1136/adc.2003.027334</identifier><identifier>PMID: 15102717</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Babies ; Birth weight ; Brain - anatomy & histology ; Brain - pathology ; Brain Injuries - diagnosis ; brain injury ; computed tomography ; encephalopathy ; Flow velocity ; fMRI ; functional MR imaging ; Humans ; Hypoxia ; hypoxia-ischaemia ; Infant ; Infant, Newborn ; Infants ; Intensive care ; Intensive Care, Neonatal - methods ; Leading ; magnetic resonance ; Magnetic Resonance Imaging ; Medical imaging ; Metabolic disorders ; neonatal encephalopathy ; NMR ; nuclear magnetic resonance ; periventricular leucomalacia ; prognosis ; PVL ; Spectrum analysis ; Traumatic brain injury ; ultrasonography ; white matter damage ; WMD</subject><ispartof>Archives of disease in childhood. Fetal and neonatal edition, 2004-05, Vol.89 (3), p.F193-F197</ispartof><rights>Copyright 2004 Archives of Disease in Childhood</rights><rights>Copyright: 2004 Copyright 2004 Archives of Disease in Childhood</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b490t-ee033a0b41ea4a21e2e934c0fd193c416259ec634e1775c803a91d325c3f66343</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721681/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721681/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15102717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Robertson, N J</creatorcontrib><creatorcontrib>Wyatt, J S</creatorcontrib><title>The magnetic resonance revolution in brain imaging: impact on neonatal intensive care</title><title>Archives of disease in childhood. Fetal and neonatal edition</title><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><description>Despite these advances, perinatal hypoxia-ischaemia (HI) is experienced by about 4/1000 live term births, and disability rates among very low birthweight (birth weight < 1500 g) infants remain high, with 5-15% showing major spastic abnormalities and an additional 25-50% or more having deficits in cognition and behaviour. 4- 6 Neuroimaging is needed in at risk infants, as clinical evaluation may not provide adequate diagnostic or prognostic information and has two principal functions: (a) early diagnosis of brain injury so that appropriate medical management can be provided; (b) detection of lesions associated with long term neurodevelopmental disability. [...]diffusion weighted imaging has not been proven to be effective as a prognostic tool in NE. 14 This is surprising, as diffusion weighted imaging in the adult brain 15 and experimental models 16 of stroke has revolutionised the possibility of early diagnosis and intervention, often revealing image abnormalities on water diffusion maps well before CT or conventional MR. 31P and 1H MR spectroscopy (giving quantitative information on brain energetics, intracellular pH (pHi) and lactate) can give early prognostic information on brain injury severity.</description><subject>Babies</subject><subject>Birth weight</subject><subject>Brain - anatomy & histology</subject><subject>Brain - pathology</subject><subject>Brain Injuries - diagnosis</subject><subject>brain injury</subject><subject>computed tomography</subject><subject>encephalopathy</subject><subject>Flow velocity</subject><subject>fMRI</subject><subject>functional MR imaging</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>hypoxia-ischaemia</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Intensive care</subject><subject>Intensive Care, Neonatal - methods</subject><subject>Leading</subject><subject>magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical imaging</subject><subject>Metabolic disorders</subject><subject>neonatal encephalopathy</subject><subject>NMR</subject><subject>nuclear magnetic resonance</subject><subject>periventricular leucomalacia</subject><subject>prognosis</subject><subject>PVL</subject><subject>Spectrum analysis</subject><subject>Traumatic brain injury</subject><subject>ultrasonography</subject><subject>white matter damage</subject><subject>WMD</subject><issn>1359-2998</issn><issn>1468-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkcuP0zAQxi0EYh9w5oYiIXFAStdjO3HCAQlVLAVWvLS7V8txp12X1Cm2U8F_z6xSLY8LF3vk-c3n-fQx9gT4DEDWZ3bpZoJzOeNCS6nusWNQdVMKXon7VMuqLUXbNkfsJKUN5xy01g_ZEVRAA6CP2dXlDRZbuw6YvSsipiHY4JCq_dCP2Q-h8KHooqXTE-fD-iUVO-tyQb2AxGfbE5QxJL_HwtmIj9iDle0TPj7cp-zq_M3lfFFefHr7bv76ouxUy3OJyKW0vFOAVlkBKLCVyvHVElrpFNSiatHVUiHtXbmGS9vCUorKyVVNz_KUvZp0d2O3xaXDkKPtzS7SqvGnGaw3f3eCvzHrYW9AC6gbIIHnB4E4fB8xZbP1yWHfW3I2JqOhqQGqmsBn_4CbYYyBzJFWwxVvARqizibKxSGliKu7VYCb28AMBWZuAzNTYDTx9E8Hv_lDQgSUE-BTxh93fRu_mVpLXZmP13Pz-cu1-rr48N4siH8x8d1289_ffwGrtK2w</recordid><startdate>200405</startdate><enddate>200405</enddate><creator>Robertson, N J</creator><creator>Wyatt, J S</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200405</creationdate><title>The magnetic resonance revolution in brain imaging: impact on neonatal intensive care</title><author>Robertson, N J ; Wyatt, J S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b490t-ee033a0b41ea4a21e2e934c0fd193c416259ec634e1775c803a91d325c3f66343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Babies</topic><topic>Birth weight</topic><topic>Brain - anatomy & histology</topic><topic>Brain - pathology</topic><topic>Brain Injuries - diagnosis</topic><topic>brain injury</topic><topic>computed tomography</topic><topic>encephalopathy</topic><topic>Flow velocity</topic><topic>fMRI</topic><topic>functional MR imaging</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>hypoxia-ischaemia</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Intensive care</topic><topic>Intensive Care, Neonatal - methods</topic><topic>Leading</topic><topic>magnetic resonance</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical imaging</topic><topic>Metabolic disorders</topic><topic>neonatal encephalopathy</topic><topic>NMR</topic><topic>nuclear magnetic resonance</topic><topic>periventricular leucomalacia</topic><topic>prognosis</topic><topic>PVL</topic><topic>Spectrum analysis</topic><topic>Traumatic brain injury</topic><topic>ultrasonography</topic><topic>white matter damage</topic><topic>WMD</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robertson, N J</creatorcontrib><creatorcontrib>Wyatt, J S</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood. 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[...]diffusion weighted imaging has not been proven to be effective as a prognostic tool in NE. 14 This is surprising, as diffusion weighted imaging in the adult brain 15 and experimental models 16 of stroke has revolutionised the possibility of early diagnosis and intervention, often revealing image abnormalities on water diffusion maps well before CT or conventional MR. 31P and 1H MR spectroscopy (giving quantitative information on brain energetics, intracellular pH (pHi) and lactate) can give early prognostic information on brain injury severity.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>15102717</pmid><doi>10.1136/adc.2003.027334</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Babies Birth weight Brain - anatomy & histology Brain - pathology Brain Injuries - diagnosis brain injury computed tomography encephalopathy Flow velocity fMRI functional MR imaging Humans Hypoxia hypoxia-ischaemia Infant Infant, Newborn Infants Intensive care Intensive Care, Neonatal - methods Leading magnetic resonance Magnetic Resonance Imaging Medical imaging Metabolic disorders neonatal encephalopathy NMR nuclear magnetic resonance periventricular leucomalacia prognosis PVL Spectrum analysis Traumatic brain injury ultrasonography white matter damage WMD |
| title | The magnetic resonance revolution in brain imaging: impact on neonatal intensive care |
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