Neonatal thrombocytopenia: causes and management
Neonatal thrombocytopenia is a common clinical problem. Thrombocytopenia presenting in the first 72 hours of life is usually secondary to placental insufficiency and caused by reduced platelet production; fortunately most episodes are mild or moderate and resolve spontaneously. Thrombocytopenia pres...
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| Veröffentlicht in: | Archives of disease in childhood. Fetal and neonatal edition 2003-09, Vol.88 (5), p.F359-364 |
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| container_title | Archives of disease in childhood. Fetal and neonatal edition |
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| creator | Roberts, I Murray, N A |
| description | Neonatal thrombocytopenia is a common clinical problem. Thrombocytopenia presenting in the first 72 hours of life is usually secondary to placental insufficiency and caused by reduced platelet production; fortunately most episodes are mild or moderate and resolve spontaneously. Thrombocytopenia presenting after 72 hours of age is usually secondary to sepsis or necrotising enterocolitis and is usually more severe and prolonged. Platelet transfusion remains the only treatment. There is a need for trials to define the safe lower limit for platelet count and which neonates will benefit from treatment. |
| doi_str_mv | 10.1136/fn.88.5.F359 |
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Thrombocytopenia presenting in the first 72 hours of life is usually secondary to placental insufficiency and caused by reduced platelet production; fortunately most episodes are mild or moderate and resolve spontaneously. Thrombocytopenia presenting after 72 hours of age is usually secondary to sepsis or necrotising enterocolitis and is usually more severe and prolonged. Platelet transfusion remains the only treatment. There is a need for trials to define the safe lower limit for platelet count and which neonates will benefit from treatment.</description><identifier>ISSN: 1359-2998</identifier><identifier>EISSN: 1468-2052</identifier><identifier>DOI: 10.1136/fn.88.5.F359</identifier><identifier>PMID: 12937037</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Blood platelets ; Care and treatment ; Causes of ; Congenital diseases ; Cytokines ; Cytomegalovirus ; Demographic aspects ; Diseases ; Fetus ; Forecasting ; Growth factors ; Health aspects ; HPA ; human platelet antigen ; Humans ; ICH ; Infant, Newborn ; Infants (Newborn) ; Infants (Premature) ; Infections ; Intensive care ; Intensive Care, Neonatal ; interleukin ; interleukin 11 ; intracranial haemorrhage ; intravenous immunoglobulin ; IVIG ; Metabolic disorders ; Mortality ; NAITP ; NEC ; necrotising enterocolitis ; neonatal alloimmune ; neonatal intensive care unit ; Neonates ; NICU ; Perinatal Care - methods ; Platelet Transfusion - methods ; platelets ; Preeclampsia ; Premature birth ; Prenatal Care - methods ; preterm ; Prevention ; Probiotics ; Purpura, Thrombocytopenic, Idiopathic - etiology ; Purpura, Thrombocytopenic, Idiopathic - therapy ; recombinant human ; Respiratory distress syndrome ; Review ; Sepsis ; Thrombocytopenia ; Thrombocytopenia - etiology ; Thrombocytopenia - therapy ; thrombopoietin ; Thrombosis ; Tpo</subject><ispartof>Archives of disease in childhood. Fetal and neonatal edition, 2003-09, Vol.88 (5), p.F359-364</ispartof><rights>Copyright 2003 Archives of Disease in Childhood</rights><rights>COPYRIGHT 2003 BMJ Publishing Group Ltd.</rights><rights>Copyright: 2003 Copyright 2003 Archives of Disease in Childhood</rights><rights>Copyright National Library of Medicine - MEDLINE Abstracts Sep 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b691t-e956a81d92c48caa0b6546d164ef83f83af2e119fa9e25befdba4d71f05932d13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721612/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721612/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,313,314,727,780,784,792,885,27922,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12937037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roberts, I</creatorcontrib><creatorcontrib>Murray, N A</creatorcontrib><title>Neonatal thrombocytopenia: causes and management</title><title>Archives of disease in childhood. Fetal and neonatal edition</title><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><description>Neonatal thrombocytopenia is a common clinical problem. Thrombocytopenia presenting in the first 72 hours of life is usually secondary to placental insufficiency and caused by reduced platelet production; fortunately most episodes are mild or moderate and resolve spontaneously. Thrombocytopenia presenting after 72 hours of age is usually secondary to sepsis or necrotising enterocolitis and is usually more severe and prolonged. Platelet transfusion remains the only treatment. There is a need for trials to define the safe lower limit for platelet count and which neonates will benefit from treatment.</description><subject>Blood platelets</subject><subject>Care and treatment</subject><subject>Causes of</subject><subject>Congenital diseases</subject><subject>Cytokines</subject><subject>Cytomegalovirus</subject><subject>Demographic aspects</subject><subject>Diseases</subject><subject>Fetus</subject><subject>Forecasting</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>HPA</subject><subject>human platelet antigen</subject><subject>Humans</subject><subject>ICH</subject><subject>Infant, Newborn</subject><subject>Infants (Newborn)</subject><subject>Infants (Premature)</subject><subject>Infections</subject><subject>Intensive care</subject><subject>Intensive Care, Neonatal</subject><subject>interleukin</subject><subject>interleukin 11</subject><subject>intracranial haemorrhage</subject><subject>intravenous immunoglobulin</subject><subject>IVIG</subject><subject>Metabolic disorders</subject><subject>Mortality</subject><subject>NAITP</subject><subject>NEC</subject><subject>necrotising enterocolitis</subject><subject>neonatal alloimmune</subject><subject>neonatal intensive care unit</subject><subject>Neonates</subject><subject>NICU</subject><subject>Perinatal Care - methods</subject><subject>Platelet Transfusion - methods</subject><subject>platelets</subject><subject>Preeclampsia</subject><subject>Premature birth</subject><subject>Prenatal Care - methods</subject><subject>preterm</subject><subject>Prevention</subject><subject>Probiotics</subject><subject>Purpura, Thrombocytopenic, Idiopathic - etiology</subject><subject>Purpura, Thrombocytopenic, Idiopathic - therapy</subject><subject>recombinant human</subject><subject>Respiratory distress syndrome</subject><subject>Review</subject><subject>Sepsis</subject><subject>Thrombocytopenia</subject><subject>Thrombocytopenia - etiology</subject><subject>Thrombocytopenia - therapy</subject><subject>thrombopoietin</subject><subject>Thrombosis</subject><subject>Tpo</subject><issn>1359-2998</issn><issn>1468-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kt-L1DAQx4so3g9981kWhfPF1kzS_PJBOFbXHxyr4KmPIW0ne91rk7VpxfvvzbLLncopCSTMfGbmm5lk2SMgBQATL5wvlCp4sWBc38kOoRQqp4TTu-meTDnVWh1kRzGuCSEgpbyfHQDVTBImDzOyxODtaLvZeDGEvgr11Rg26Fv7clbbKWKcWd_MeuvtCnv044PsnrNdxIf78zj7snhzPn-Xn318-35-epZXQsOYo-bCKmg0rUtVW0sqwUvRgCjRKZa2dRQBtLMaKa_QNZUtGwmOcM1oA-w4e7XLu5mqHps6lR5sZzZD29vhygTbmj89vr0wq_DDgKQggKYEJ_sEQ_g-YRxN38Yau856DFM0kglSgtQJfPIXuA7T4NPjDGW85FyJrZyn_4JAKiKFKjlJVL6jVrZD03oXkrR6hR6TwuDRtcl8CkSxNAGx1VjcwqfVYN_WtwY83wXUQ4hxQHfdECBm-x2M80Ypw832OyT88e9NvIH3878R3MYRf1777XBphGSSm-XXuTmnrz99WH5emG-Jf7bjq379_9K_AM8Kyto</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>Roberts, I</creator><creator>Murray, N A</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><general>National Library of Medicine - MEDLINE Abstracts</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20030901</creationdate><title>Neonatal thrombocytopenia: causes and management</title><author>Roberts, I ; Murray, N A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b691t-e956a81d92c48caa0b6546d164ef83f83af2e119fa9e25befdba4d71f05932d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Blood platelets</topic><topic>Care and treatment</topic><topic>Causes of</topic><topic>Congenital diseases</topic><topic>Cytokines</topic><topic>Cytomegalovirus</topic><topic>Demographic aspects</topic><topic>Diseases</topic><topic>Fetus</topic><topic>Forecasting</topic><topic>Growth factors</topic><topic>Health aspects</topic><topic>HPA</topic><topic>human platelet antigen</topic><topic>Humans</topic><topic>ICH</topic><topic>Infant, Newborn</topic><topic>Infants (Newborn)</topic><topic>Infants (Premature)</topic><topic>Infections</topic><topic>Intensive care</topic><topic>Intensive Care, Neonatal</topic><topic>interleukin</topic><topic>interleukin 11</topic><topic>intracranial haemorrhage</topic><topic>intravenous immunoglobulin</topic><topic>IVIG</topic><topic>Metabolic disorders</topic><topic>Mortality</topic><topic>NAITP</topic><topic>NEC</topic><topic>necrotising enterocolitis</topic><topic>neonatal alloimmune</topic><topic>neonatal intensive care unit</topic><topic>Neonates</topic><topic>NICU</topic><topic>Perinatal Care - methods</topic><topic>Platelet Transfusion - methods</topic><topic>platelets</topic><topic>Preeclampsia</topic><topic>Premature birth</topic><topic>Prenatal Care - methods</topic><topic>preterm</topic><topic>Prevention</topic><topic>Probiotics</topic><topic>Purpura, Thrombocytopenic, Idiopathic - etiology</topic><topic>Purpura, Thrombocytopenic, Idiopathic - therapy</topic><topic>recombinant human</topic><topic>Respiratory distress syndrome</topic><topic>Review</topic><topic>Sepsis</topic><topic>Thrombocytopenia</topic><topic>Thrombocytopenia - etiology</topic><topic>Thrombocytopenia - therapy</topic><topic>thrombopoietin</topic><topic>Thrombosis</topic><topic>Tpo</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roberts, I</creatorcontrib><creatorcontrib>Murray, N A</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roberts, I</au><au>Murray, N A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal thrombocytopenia: causes and management</atitle><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>88</volume><issue>5</issue><spage>F359</spage><epage>364</epage><pages>F359-364</pages><issn>1359-2998</issn><eissn>1468-2052</eissn><abstract>Neonatal thrombocytopenia is a common clinical problem. Thrombocytopenia presenting in the first 72 hours of life is usually secondary to placental insufficiency and caused by reduced platelet production; fortunately most episodes are mild or moderate and resolve spontaneously. Thrombocytopenia presenting after 72 hours of age is usually secondary to sepsis or necrotising enterocolitis and is usually more severe and prolonged. Platelet transfusion remains the only treatment. There is a need for trials to define the safe lower limit for platelet count and which neonates will benefit from treatment.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>12937037</pmid><doi>10.1136/fn.88.5.F359</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1359-2998 |
| ispartof | Archives of disease in childhood. Fetal and neonatal edition, 2003-09, Vol.88 (5), p.F359-364 |
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| subjects | Blood platelets Care and treatment Causes of Congenital diseases Cytokines Cytomegalovirus Demographic aspects Diseases Fetus Forecasting Growth factors Health aspects HPA human platelet antigen Humans ICH Infant, Newborn Infants (Newborn) Infants (Premature) Infections Intensive care Intensive Care, Neonatal interleukin interleukin 11 intracranial haemorrhage intravenous immunoglobulin IVIG Metabolic disorders Mortality NAITP NEC necrotising enterocolitis neonatal alloimmune neonatal intensive care unit Neonates NICU Perinatal Care - methods Platelet Transfusion - methods platelets Preeclampsia Premature birth Prenatal Care - methods preterm Prevention Probiotics Purpura, Thrombocytopenic, Idiopathic - etiology Purpura, Thrombocytopenic, Idiopathic - therapy recombinant human Respiratory distress syndrome Review Sepsis Thrombocytopenia Thrombocytopenia - etiology Thrombocytopenia - therapy thrombopoietin Thrombosis Tpo |
| title | Neonatal thrombocytopenia: causes and management |
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