Changes in pulmonary arterial pressure in preterm infants with chronic lung disease
BACKGROUND Pulmonary arterial pressure (PAP) is raised in preterm infants with respiratory distress syndrome who subsequently develop chronic lung disease. The natural history of pulmonary hypertension in infants with chronic lung disease is unknown. OBJECTIVES To investigate changes in PAP, assesse...
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| Veröffentlicht in: | Archives of disease in childhood. Fetal and neonatal edition 2000-05, Vol.82 (3), p.F243-F247 |
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| description | BACKGROUND Pulmonary arterial pressure (PAP) is raised in preterm infants with respiratory distress syndrome who subsequently develop chronic lung disease. The natural history of pulmonary hypertension in infants with chronic lung disease is unknown. OBJECTIVES To investigate changes in PAP, assessed non-invasively using Doppler echocardiography, in infants with chronic lung disease during the 1st year of life. METHODS Serial examinations were performed in infants with chronic lung disease and healthy preterm infants. The Doppler derived acceleration time to right ventricular ejection time ratio (AT/RVET) was calculated from measurements made from the pulmonary artery velocity waveform. RESULTS A total of 248 examinations were performed in 54 infants with chronic lung disease and 44 healthy preterm infants. The median AT/RVET was significantly lower in infants with chronic lung disease than in healthy preterm infants (0.31 v 0.37). AT/RVET significantly correlated with age corrected for prematurity in both infants with chronic lung disease (r = 0.67) and healthy infants (r = 0.55). There was no significant difference between the rate of change in AT/RVET between the two groups. In infants with chronic lung disease, multivariate analysis showed that AT/RVET was significantly independently associated with age and inversely with duration of supplemental oxygen treatment. Median AT/RVET was significantly lower in infants with chronic lung disease until 40–52 weeks of age corrected for prematurity. CONCLUSIONS Although PAP falls with increasing age in both infants with chronic lung disease and healthy preterm infants, it remains persistently raised in infants with chronic lung disease until the end of the 1st year of life. |
| doi_str_mv | 10.1136/fn.82.3.F243 |
| format | Article |
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The natural history of pulmonary hypertension in infants with chronic lung disease is unknown. OBJECTIVES To investigate changes in PAP, assessed non-invasively using Doppler echocardiography, in infants with chronic lung disease during the 1st year of life. METHODS Serial examinations were performed in infants with chronic lung disease and healthy preterm infants. The Doppler derived acceleration time to right ventricular ejection time ratio (AT/RVET) was calculated from measurements made from the pulmonary artery velocity waveform. RESULTS A total of 248 examinations were performed in 54 infants with chronic lung disease and 44 healthy preterm infants. The median AT/RVET was significantly lower in infants with chronic lung disease than in healthy preterm infants (0.31 v 0.37). AT/RVET significantly correlated with age corrected for prematurity in both infants with chronic lung disease (r = 0.67) and healthy infants (r = 0.55). There was no significant difference between the rate of change in AT/RVET between the two groups. In infants with chronic lung disease, multivariate analysis showed that AT/RVET was significantly independently associated with age and inversely with duration of supplemental oxygen treatment. Median AT/RVET was significantly lower in infants with chronic lung disease until 40–52 weeks of age corrected for prematurity. CONCLUSIONS Although PAP falls with increasing age in both infants with chronic lung disease and healthy preterm infants, it remains persistently raised in infants with chronic lung disease until the end of the 1st year of life.</description><identifier>ISSN: 1359-2998</identifier><identifier>EISSN: 1468-2052</identifier><identifier>DOI: 10.1136/fn.82.3.F243</identifier><identifier>PMID: 10794795</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>acceleration time to right ventricular ejection time ratio ; Age ; Age Factors ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Babies ; Biological and medical sciences ; Birth weight ; Blood Pressure ; Case-Control Studies ; chronic lung disease ; Doppler echocardiography ; Echocardiography, Doppler ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Humans ; Hypertension ; Infant ; Infant, Newborn ; Infant, Premature - physiology ; Infants ; Intensive care medicine ; Lung diseases ; Lung Diseases, Obstructive - diagnostic imaging ; Lung Diseases, Obstructive - physiopathology ; Lung Diseases, Obstructive - therapy ; Medical sciences ; Menstruation ; Mortality ; Multivariate Analysis ; Original ; Oxygen Inhalation Therapy - adverse effects ; Premature birth ; prematurity ; pulmonary arterial pressure ; Pulmonary arteries ; Pulmonary Artery - diagnostic imaging ; Pulmonary Artery - physiopathology ; Pulmonary hypertension ; Respiratory distress syndrome ; Respiratory therapy ; Studies ; Time Factors ; Ultrasonic imaging ; Veins & arteries ; Velocity ; Ventilation</subject><ispartof>Archives of disease in childhood. Fetal and neonatal edition, 2000-05, Vol.82 (3), p.F243-F247</ispartof><rights>Royal College of Paediatrics and Child Health</rights><rights>2000 INIST-CNRS</rights><rights>Copyright: 2000 Royal College of Paediatrics and Child Health</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b550t-f983d3be33c802f633f1e1f1eb374512a50de4b638f142de4970ae5098bc2cdb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721073/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721073/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1441903$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10794795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Subhedar, N V</creatorcontrib><creatorcontrib>Shaw, N J</creatorcontrib><title>Changes in pulmonary arterial pressure in preterm infants with chronic lung disease</title><title>Archives of disease in childhood. Fetal and neonatal edition</title><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><description>BACKGROUND Pulmonary arterial pressure (PAP) is raised in preterm infants with respiratory distress syndrome who subsequently develop chronic lung disease. The natural history of pulmonary hypertension in infants with chronic lung disease is unknown. OBJECTIVES To investigate changes in PAP, assessed non-invasively using Doppler echocardiography, in infants with chronic lung disease during the 1st year of life. METHODS Serial examinations were performed in infants with chronic lung disease and healthy preterm infants. The Doppler derived acceleration time to right ventricular ejection time ratio (AT/RVET) was calculated from measurements made from the pulmonary artery velocity waveform. RESULTS A total of 248 examinations were performed in 54 infants with chronic lung disease and 44 healthy preterm infants. The median AT/RVET was significantly lower in infants with chronic lung disease than in healthy preterm infants (0.31 v 0.37). AT/RVET significantly correlated with age corrected for prematurity in both infants with chronic lung disease (r = 0.67) and healthy infants (r = 0.55). There was no significant difference between the rate of change in AT/RVET between the two groups. In infants with chronic lung disease, multivariate analysis showed that AT/RVET was significantly independently associated with age and inversely with duration of supplemental oxygen treatment. Median AT/RVET was significantly lower in infants with chronic lung disease until 40–52 weeks of age corrected for prematurity. CONCLUSIONS Although PAP falls with increasing age in both infants with chronic lung disease and healthy preterm infants, it remains persistently raised in infants with chronic lung disease until the end of the 1st year of life.</description><subject>acceleration time to right ventricular ejection time ratio</subject><subject>Age</subject><subject>Age Factors</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Babies</subject><subject>Biological and medical sciences</subject><subject>Birth weight</subject><subject>Blood Pressure</subject><subject>Case-Control Studies</subject><subject>chronic lung disease</subject><subject>Doppler echocardiography</subject><subject>Echocardiography, Doppler</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - physiology</subject><subject>Infants</subject><subject>Intensive care medicine</subject><subject>Lung diseases</subject><subject>Lung Diseases, Obstructive - diagnostic imaging</subject><subject>Lung Diseases, Obstructive - physiopathology</subject><subject>Lung Diseases, Obstructive - therapy</subject><subject>Medical sciences</subject><subject>Menstruation</subject><subject>Mortality</subject><subject>Multivariate Analysis</subject><subject>Original</subject><subject>Oxygen Inhalation Therapy - adverse effects</subject><subject>Premature birth</subject><subject>prematurity</subject><subject>pulmonary arterial pressure</subject><subject>Pulmonary arteries</subject><subject>Pulmonary Artery - diagnostic imaging</subject><subject>Pulmonary Artery - physiopathology</subject><subject>Pulmonary hypertension</subject><subject>Respiratory distress syndrome</subject><subject>Respiratory therapy</subject><subject>Studies</subject><subject>Time Factors</subject><subject>Ultrasonic imaging</subject><subject>Veins & arteries</subject><subject>Velocity</subject><subject>Ventilation</subject><issn>1359-2998</issn><issn>1468-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtv1DAUhS0EoqWwY40igeiGDH7Esb1BQiNakKphUV47y3GuZzwkztROePz7eppRKSxYWD7y-XR0rw9CTwleEMLq1y4sJF2wxRmt2D10TKpalhRzej9rxlVJlZJH6FFKW4wxEUI8REcEC1UJxY_R5XJjwhpS4UOxm7p-CCb-LkwcIXrTFbsIKU0RbuwI-bXP0pkwpuKnHzeF3cQheFt0U1gXrU9gEjxGD5zpEjw53Cfo89m7T8v35cXH8w_LtxdlwzkeS6cka1kDjFmJqasZcwRIPg0TFSfUcNxC1dRMOlLRLJXABjhWsrHUtg07QW_m3N3U9NBaCGM0nd5F3-cl9GC8_tsJfqPXww9NBM0_wHLAy0NAHK4mSKPufbLQdSbAMCUtCJaCCpzB5_-A22GKIS-XsyQWQipMM_VqpmwcUorgbkchWO-70i5oSTXT-64y_uzu-HfguZwMvDgAJlnTuWiC9ekPV1VE4X1OOWM-jfDr1jbxu64FE1yvviz1t9Xq6yVnVIvMn85802__P-E1Ib-5Bw</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>Subhedar, N V</creator><creator>Shaw, N J</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20000501</creationdate><title>Changes in pulmonary arterial pressure in preterm infants with chronic lung disease</title><author>Subhedar, N V ; Shaw, N J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b550t-f983d3be33c802f633f1e1f1eb374512a50de4b638f142de4970ae5098bc2cdb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>acceleration time to right ventricular ejection time ratio</topic><topic>Age</topic><topic>Age Factors</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Babies</topic><topic>Biological and medical sciences</topic><topic>Birth weight</topic><topic>Blood Pressure</topic><topic>Case-Control Studies</topic><topic>chronic lung disease</topic><topic>Doppler echocardiography</topic><topic>Echocardiography, Doppler</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - physiology</topic><topic>Infants</topic><topic>Intensive care medicine</topic><topic>Lung diseases</topic><topic>Lung Diseases, Obstructive - diagnostic imaging</topic><topic>Lung Diseases, Obstructive - physiopathology</topic><topic>Lung Diseases, Obstructive - therapy</topic><topic>Medical sciences</topic><topic>Menstruation</topic><topic>Mortality</topic><topic>Multivariate Analysis</topic><topic>Original</topic><topic>Oxygen Inhalation Therapy - adverse effects</topic><topic>Premature birth</topic><topic>prematurity</topic><topic>pulmonary arterial pressure</topic><topic>Pulmonary arteries</topic><topic>Pulmonary Artery - diagnostic imaging</topic><topic>Pulmonary Artery - physiopathology</topic><topic>Pulmonary hypertension</topic><topic>Respiratory distress syndrome</topic><topic>Respiratory therapy</topic><topic>Studies</topic><topic>Time Factors</topic><topic>Ultrasonic imaging</topic><topic>Veins & arteries</topic><topic>Velocity</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Subhedar, N V</creatorcontrib><creatorcontrib>Shaw, N J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Subhedar, N V</au><au>Shaw, N J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in pulmonary arterial pressure in preterm infants with chronic lung disease</atitle><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><date>2000-05-01</date><risdate>2000</risdate><volume>82</volume><issue>3</issue><spage>F243</spage><epage>F247</epage><pages>F243-F247</pages><issn>1359-2998</issn><eissn>1468-2052</eissn><abstract>BACKGROUND Pulmonary arterial pressure (PAP) is raised in preterm infants with respiratory distress syndrome who subsequently develop chronic lung disease. The natural history of pulmonary hypertension in infants with chronic lung disease is unknown. OBJECTIVES To investigate changes in PAP, assessed non-invasively using Doppler echocardiography, in infants with chronic lung disease during the 1st year of life. METHODS Serial examinations were performed in infants with chronic lung disease and healthy preterm infants. The Doppler derived acceleration time to right ventricular ejection time ratio (AT/RVET) was calculated from measurements made from the pulmonary artery velocity waveform. RESULTS A total of 248 examinations were performed in 54 infants with chronic lung disease and 44 healthy preterm infants. The median AT/RVET was significantly lower in infants with chronic lung disease than in healthy preterm infants (0.31 v 0.37). AT/RVET significantly correlated with age corrected for prematurity in both infants with chronic lung disease (r = 0.67) and healthy infants (r = 0.55). There was no significant difference between the rate of change in AT/RVET between the two groups. In infants with chronic lung disease, multivariate analysis showed that AT/RVET was significantly independently associated with age and inversely with duration of supplemental oxygen treatment. Median AT/RVET was significantly lower in infants with chronic lung disease until 40–52 weeks of age corrected for prematurity. CONCLUSIONS Although PAP falls with increasing age in both infants with chronic lung disease and healthy preterm infants, it remains persistently raised in infants with chronic lung disease until the end of the 1st year of life.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>10794795</pmid><doi>10.1136/fn.82.3.F243</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | acceleration time to right ventricular ejection time ratio Age Age Factors Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Babies Biological and medical sciences Birth weight Blood Pressure Case-Control Studies chronic lung disease Doppler echocardiography Echocardiography, Doppler Emergency and intensive care: neonates and children. Prematurity. Sudden death Humans Hypertension Infant Infant, Newborn Infant, Premature - physiology Infants Intensive care medicine Lung diseases Lung Diseases, Obstructive - diagnostic imaging Lung Diseases, Obstructive - physiopathology Lung Diseases, Obstructive - therapy Medical sciences Menstruation Mortality Multivariate Analysis Original Oxygen Inhalation Therapy - adverse effects Premature birth prematurity pulmonary arterial pressure Pulmonary arteries Pulmonary Artery - diagnostic imaging Pulmonary Artery - physiopathology Pulmonary hypertension Respiratory distress syndrome Respiratory therapy Studies Time Factors Ultrasonic imaging Veins & arteries Velocity Ventilation |
| title | Changes in pulmonary arterial pressure in preterm infants with chronic lung disease |
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