Distinct but Overlapping Roles of Histone Acetylase PCAF and of the Closely Related PCAF-B/GCN5 in Mouse Embryogenesis

PCAF plays a role in transcriptional activation, cell-cycle arrest, and cell differentiation in cultured cells. PCAF contributes to transcriptional activation by acetylating chromatin and transcription factors through its intrinsic histone acetylase activity. In this report, we present evidence for...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-10, Vol.97 (21), p.11303-11306
Hauptverfasser:	Yamauchi, Teruo, Yamauchi, Jun, Kuwata, Takeshi, Tamura, Tomohiko, Yamashita, Tsuyoshi, Bae, Nancy, Westphal, Heiner, Ozato, Keiko, Nakatani, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - genetics Acetyltransferases - physiology Alleles Animals Biological Sciences Cell Cycle Proteins Cellular biology Embryogenesis Embryonic and Fetal Development - genetics Embryonic and Fetal Development - physiology Embryos GCN5 gene GCN5 protein Gene Expression Profiling Genomics histone acetylase Histone Acetyltransferases Histones Liver Lungs Messenger RNA Mice Mice, Inbred C57BL Mice, Knockout p300-CBP Transcription Factors PCAF gene PCAF protein Phenotypes Proteins RNA, Messenger - genetics Rodents Saccharomyces cerevisiae Proteins Trans-Activators - genetics Trans-Activators - physiology Transcription Factors
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