The significance of antineutrophil cytoplasmic antibody in microscopic polyangitis and classic polyarteritis nodosa
AIMS To describe the distribution and features of classic polyarteritis nodosa (PAN) and microscopic polyarteritis (MPA) and the importance of antineutrophil cytoplasmic antibody (ANCA) in childhood PAN. METHODS Classic PAN was diagnosed in 15 patients based on the presence of aneurysms on angiograp...
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| Veröffentlicht in: | Archives of disease in childhood 2001-11, Vol.85 (5), p.427-430 |
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| creator | Bakkaloglu, A Ozen, S Baskin, E Besbas, N Gur-Guven, A Kasapçopur, O Tinaztepe, K |
| description | AIMS To describe the distribution and features of classic polyarteritis nodosa (PAN) and microscopic polyarteritis (MPA) and the importance of antineutrophil cytoplasmic antibody (ANCA) in childhood PAN. METHODS Classic PAN was diagnosed in 15 patients based on the presence of aneurysms on angiography in 10 patients and of necrotising vasculitis in medium sized arteries in five. MPA was diagnosed in 10 patients, based on characteristic findings at renal biopsy in six and by the presence of small sized necrotising arteritis in four. Serum ANCA was detected initially by indirect immunofluorescence (IIF) followed by an immunoassay for myeloperoxidase (MPO) in each case. RESULTS The median age of the patients with classic PAN and MPA was 12 (range 8–17) and 9.5 (range 5–14) respectively. None of the patients with classic PAN had renal failure. Six of the patients with MPA presented with renal failure; four progressed to chronic renal failure. Clinically evident pulmonary–renal syndrome was present in three of the 10 patients with MPA. IIF for ANCA in classic PAN was negative in nine, showed mild staining patterns in six, and in one MPO-ELISA was mildly increased. IIF for ANCA in MPA revealed very strong perinuclear ANCA staining in nine and atypical staining in one. In MPA, median MPO-ELISA level was 42.5 EU/ml (range 20–250). Treatment of childhood PAN was satisfactory with effective treatment; however relapses did occur. CONCLUSION ANCA is useful in the diagnosis and follow up of MPA. |
| doi_str_mv | 10.1136/adc.85.5.427 |
| format | Article |
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METHODS Classic PAN was diagnosed in 15 patients based on the presence of aneurysms on angiography in 10 patients and of necrotising vasculitis in medium sized arteries in five. MPA was diagnosed in 10 patients, based on characteristic findings at renal biopsy in six and by the presence of small sized necrotising arteritis in four. Serum ANCA was detected initially by indirect immunofluorescence (IIF) followed by an immunoassay for myeloperoxidase (MPO) in each case. RESULTS The median age of the patients with classic PAN and MPA was 12 (range 8–17) and 9.5 (range 5–14) respectively. None of the patients with classic PAN had renal failure. Six of the patients with MPA presented with renal failure; four progressed to chronic renal failure. Clinically evident pulmonary–renal syndrome was present in three of the 10 patients with MPA. IIF for ANCA in classic PAN was negative in nine, showed mild staining patterns in six, and in one MPO-ELISA was mildly increased. IIF for ANCA in MPA revealed very strong perinuclear ANCA staining in nine and atypical staining in one. In MPA, median MPO-ELISA level was 42.5 EU/ml (range 20–250). Treatment of childhood PAN was satisfactory with effective treatment; however relapses did occur. CONCLUSION ANCA is useful in the diagnosis and follow up of MPA.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.85.5.427</identifier><identifier>PMID: 11668111</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Adolescent ; Anatomy ; ANCA ; Antibodies, Antineutrophil Cytoplasmic - blood ; Antigens ; Arteritis - complications ; Arteritis - diagnosis ; Arteritis - immunology ; Biological and medical sciences ; Biomarkers - blood ; Child ; Child, Preschool ; classic polyarteritis ; Clinical Diagnosis ; Diagnosis ; Earthquakes ; Enzymes ; Female ; Fever ; Fluorescent Antibody Technique, Indirect ; Follow-Up Studies ; Humans ; Hypertension ; Images in Paediatric Medicine ; Kidney diseases ; Laboratories ; Male ; Medical sciences ; microscopic polyarteritis ; Mortality ; Mutation ; Nervous system ; Neutrophils ; Patients ; Periarteritis nodosa ; Peroxidase - immunology ; Polyarteritis nodosa ; Polyarteritis Nodosa - complications ; Polyarteritis Nodosa - diagnosis ; Polyarteritis Nodosa - immunology ; Prognosis ; Renal Insufficiency - etiology ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Statistical Analysis</subject><ispartof>Archives of disease in childhood, 2001-11, Vol.85 (5), p.427-430</ispartof><rights>Royal College of Paediatrics and Child Health</rights><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2001 BMJ Publishing Group Ltd.</rights><rights>COPYRIGHT 2001 BMJ Publishing Group Ltd.</rights><rights>Copyright: 2001 Royal College of Paediatrics and Child Health</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b719t-4648041b49899e209fa6a05c5e00e2de3a7da83d02256db808b797bdd287364d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1718965/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1718965/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14124720$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11668111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bakkaloglu, A</creatorcontrib><creatorcontrib>Ozen, S</creatorcontrib><creatorcontrib>Baskin, E</creatorcontrib><creatorcontrib>Besbas, N</creatorcontrib><creatorcontrib>Gur-Guven, A</creatorcontrib><creatorcontrib>Kasapçopur, O</creatorcontrib><creatorcontrib>Tinaztepe, K</creatorcontrib><title>The significance of antineutrophil cytoplasmic antibody in microscopic polyangitis and classic polyarteritis nodosa</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>AIMS To describe the distribution and features of classic polyarteritis nodosa (PAN) and microscopic polyarteritis (MPA) and the importance of antineutrophil cytoplasmic antibody (ANCA) in childhood PAN. METHODS Classic PAN was diagnosed in 15 patients based on the presence of aneurysms on angiography in 10 patients and of necrotising vasculitis in medium sized arteries in five. MPA was diagnosed in 10 patients, based on characteristic findings at renal biopsy in six and by the presence of small sized necrotising arteritis in four. Serum ANCA was detected initially by indirect immunofluorescence (IIF) followed by an immunoassay for myeloperoxidase (MPO) in each case. RESULTS The median age of the patients with classic PAN and MPA was 12 (range 8–17) and 9.5 (range 5–14) respectively. None of the patients with classic PAN had renal failure. Six of the patients with MPA presented with renal failure; four progressed to chronic renal failure. Clinically evident pulmonary–renal syndrome was present in three of the 10 patients with MPA. IIF for ANCA in classic PAN was negative in nine, showed mild staining patterns in six, and in one MPO-ELISA was mildly increased. IIF for ANCA in MPA revealed very strong perinuclear ANCA staining in nine and atypical staining in one. In MPA, median MPO-ELISA level was 42.5 EU/ml (range 20–250). Treatment of childhood PAN was satisfactory with effective treatment; however relapses did occur. CONCLUSION ANCA is useful in the diagnosis and follow up of MPA.</description><subject>Adolescent</subject><subject>Anatomy</subject><subject>ANCA</subject><subject>Antibodies, Antineutrophil Cytoplasmic - blood</subject><subject>Antigens</subject><subject>Arteritis - complications</subject><subject>Arteritis - diagnosis</subject><subject>Arteritis - immunology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>classic polyarteritis</subject><subject>Clinical Diagnosis</subject><subject>Diagnosis</subject><subject>Earthquakes</subject><subject>Enzymes</subject><subject>Female</subject><subject>Fever</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Images in Paediatric Medicine</subject><subject>Kidney diseases</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical sciences</subject><subject>microscopic polyarteritis</subject><subject>Mortality</subject><subject>Mutation</subject><subject>Nervous system</subject><subject>Neutrophils</subject><subject>Patients</subject><subject>Periarteritis nodosa</subject><subject>Peroxidase - immunology</subject><subject>Polyarteritis nodosa</subject><subject>Polyarteritis Nodosa - complications</subject><subject>Polyarteritis Nodosa - diagnosis</subject><subject>Polyarteritis Nodosa - immunology</subject><subject>Prognosis</subject><subject>Renal Insufficiency - etiology</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Statistical Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakkaloglu, A</creatorcontrib><creatorcontrib>Ozen, S</creatorcontrib><creatorcontrib>Baskin, E</creatorcontrib><creatorcontrib>Besbas, N</creatorcontrib><creatorcontrib>Gur-Guven, A</creatorcontrib><creatorcontrib>Kasapçopur, O</creatorcontrib><creatorcontrib>Tinaztepe, K</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakkaloglu, A</au><au>Ozen, S</au><au>Baskin, E</au><au>Besbas, N</au><au>Gur-Guven, A</au><au>Kasapçopur, O</au><au>Tinaztepe, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The significance of antineutrophil cytoplasmic antibody in microscopic polyangitis and classic polyarteritis nodosa</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>85</volume><issue>5</issue><spage>427</spage><epage>430</epage><pages>427-430</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>AIMS To describe the distribution and features of classic polyarteritis nodosa (PAN) and microscopic polyarteritis (MPA) and the importance of antineutrophil cytoplasmic antibody (ANCA) in childhood PAN. METHODS Classic PAN was diagnosed in 15 patients based on the presence of aneurysms on angiography in 10 patients and of necrotising vasculitis in medium sized arteries in five. MPA was diagnosed in 10 patients, based on characteristic findings at renal biopsy in six and by the presence of small sized necrotising arteritis in four. Serum ANCA was detected initially by indirect immunofluorescence (IIF) followed by an immunoassay for myeloperoxidase (MPO) in each case. RESULTS The median age of the patients with classic PAN and MPA was 12 (range 8–17) and 9.5 (range 5–14) respectively. None of the patients with classic PAN had renal failure. Six of the patients with MPA presented with renal failure; four progressed to chronic renal failure. Clinically evident pulmonary–renal syndrome was present in three of the 10 patients with MPA. IIF for ANCA in classic PAN was negative in nine, showed mild staining patterns in six, and in one MPO-ELISA was mildly increased. IIF for ANCA in MPA revealed very strong perinuclear ANCA staining in nine and atypical staining in one. In MPA, median MPO-ELISA level was 42.5 EU/ml (range 20–250). Treatment of childhood PAN was satisfactory with effective treatment; however relapses did occur. CONCLUSION ANCA is useful in the diagnosis and follow up of MPA.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>11668111</pmid><doi>10.1136/adc.85.5.427</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of disease in childhood, 2001-11, Vol.85 (5), p.427-430 |
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| subjects | Adolescent Anatomy ANCA Antibodies, Antineutrophil Cytoplasmic - blood Antigens Arteritis - complications Arteritis - diagnosis Arteritis - immunology Biological and medical sciences Biomarkers - blood Child Child, Preschool classic polyarteritis Clinical Diagnosis Diagnosis Earthquakes Enzymes Female Fever Fluorescent Antibody Technique, Indirect Follow-Up Studies Humans Hypertension Images in Paediatric Medicine Kidney diseases Laboratories Male Medical sciences microscopic polyarteritis Mortality Mutation Nervous system Neutrophils Patients Periarteritis nodosa Peroxidase - immunology Polyarteritis nodosa Polyarteritis Nodosa - complications Polyarteritis Nodosa - diagnosis Polyarteritis Nodosa - immunology Prognosis Renal Insufficiency - etiology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Statistical Analysis |
| title | The significance of antineutrophil cytoplasmic antibody in microscopic polyangitis and classic polyarteritis nodosa |
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