Generation of Oscillations by the p53-Mdm2 Feedback Loop: A Theoretical and Experimental Study

The intracellular activity of the p53 tumor suppressor protein is regulated through a feedback loop involving its transcriptional target, mdm2. We present a simple mathematical model suggesting that, under certain circumstances, oscillations in p53 and Mdm2 protein levels can emerge in response to a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-10, Vol.97 (21), p.11250-11255
Hauptverfasser:	Bar-Or, Ruth Lev, Maya, Ruth, Segel, Lee A., Alon, Uri, Levine, Arnold J., Oren, Moshe
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Biochemistry Biological Sciences Control loops DNA DNA damage Feedback Genes Humans Kinetics Mathematical induction Mdm2 gene Mice Modeling Nuclear Proteins Propagation delay Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-mdm2 Radiation damage Tumor Cells, Cultured Yield point
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