Whole body bone mineral accretion in healthy children and adolescents
Data on accretion in bone size and bone mineral content (BMC) are needed to evaluate bone mineralisation during childhood. Whole body bone mineral content (BMC) and bone area (BA) were determined by dual energy x ray absorptiometry (Hologic 1000/W) with a one year interval in healthy girls (n = 192)...
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| Veröffentlicht in: | Archives of disease in childhood 1999-07, Vol.81 (1), p.10-15 |
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| description | Data on accretion in bone size and bone mineral content (BMC) are needed to evaluate bone mineralisation during childhood. Whole body bone mineral content (BMC) and bone area (BA) were determined by dual energy x ray absorptiometry (Hologic 1000/W) with a one year interval in healthy girls (n = 192) and boys (n = 140) aged 6–19 years. Annual accretion in BMC (ΔBMC (g/year)) and BA (ΔBA (cm2/year)) according to sex and pubertal stages were calculated. ΔBA and ΔBMC were highly significantly associated with pubertal stages in girls and boys. Centile curves for ΔBA and ΔBMC according to sex and age were constructed using the LMS method. Peak ΔBA and ΔBMC values were reached earlier in girls (12.3 and 12.5 years, respectively) than in boys (13.4 and 14.2 years, respectively). The ΔBA peak was dissociated in time from the ΔBMC peak, indicating that increase in bone size occurs before increase in bone mineral content. Assuming that 32.2% of BMC consist of calcium, the median (90th centile) annual bone calcium accretion in pubertal stage III was 220 mg/day (302) and 317 mg/day (386) for girls and boys, respectively. To obtain an average bone calcium accretion, a high calcium absorption is needed during puberty. This may have implications for dietary calcium requirements at this time. |
| doi_str_mv | 10.1136/adc.81.1.10 |
| format | Article |
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Whole body bone mineral content (BMC) and bone area (BA) were determined by dual energy x ray absorptiometry (Hologic 1000/W) with a one year interval in healthy girls (n = 192) and boys (n = 140) aged 6–19 years. Annual accretion in BMC (ΔBMC (g/year)) and BA (ΔBA (cm2/year)) according to sex and pubertal stages were calculated. ΔBA and ΔBMC were highly significantly associated with pubertal stages in girls and boys. Centile curves for ΔBA and ΔBMC according to sex and age were constructed using the LMS method. Peak ΔBA and ΔBMC values were reached earlier in girls (12.3 and 12.5 years, respectively) than in boys (13.4 and 14.2 years, respectively). The ΔBA peak was dissociated in time from the ΔBMC peak, indicating that increase in bone size occurs before increase in bone mineral content. Assuming that 32.2% of BMC consist of calcium, the median (90th centile) annual bone calcium accretion in pubertal stage III was 220 mg/day (302) and 317 mg/day (386) for girls and boys, respectively. To obtain an average bone calcium accretion, a high calcium absorption is needed during puberty. This may have implications for dietary calcium requirements at this time.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.81.1.10</identifier><identifier>PMID: 10373125</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Absorptiometry, Photon ; Accretion ; Adolescent ; Adolescents ; Age ; Age Factors ; Anthropometry ; Biological and medical sciences ; Bone density ; Bone Development - physiology ; bone growth ; bone mineral content ; Bones ; Calcification, Physiologic - physiology ; Calcium ; Case Studies ; Child ; Child development ; Children & youth ; Cross-Sectional Studies ; dual energyx ray absorptiometry ; Female ; Follow-Up Studies ; Humans ; Hydroxyapatite ; Investigative techniques, diagnostic techniques (general aspects) ; Longitudinal Studies ; Male ; Medical sciences ; Mineralization ; Original ; Osteoarticular system. Muscles ; Osteoporosis ; Pathology. Cytology. Biochemistry. Spectrometry. 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Whole body bone mineral content (BMC) and bone area (BA) were determined by dual energy x ray absorptiometry (Hologic 1000/W) with a one year interval in healthy girls (n = 192) and boys (n = 140) aged 6–19 years. Annual accretion in BMC (ΔBMC (g/year)) and BA (ΔBA (cm2/year)) according to sex and pubertal stages were calculated. ΔBA and ΔBMC were highly significantly associated with pubertal stages in girls and boys. Centile curves for ΔBA and ΔBMC according to sex and age were constructed using the LMS method. Peak ΔBA and ΔBMC values were reached earlier in girls (12.3 and 12.5 years, respectively) than in boys (13.4 and 14.2 years, respectively). The ΔBA peak was dissociated in time from the ΔBMC peak, indicating that increase in bone size occurs before increase in bone mineral content. Assuming that 32.2% of BMC consist of calcium, the median (90th centile) annual bone calcium accretion in pubertal stage III was 220 mg/day (302) and 317 mg/day (386) for girls and boys, respectively. To obtain an average bone calcium accretion, a high calcium absorption is needed during puberty. This may have implications for dietary calcium requirements at this time.</description><subject>Absorptiometry, Photon</subject><subject>Accretion</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Age</subject><subject>Age Factors</subject><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>Bone density</subject><subject>Bone Development - physiology</subject><subject>bone growth</subject><subject>bone mineral content</subject><subject>Bones</subject><subject>Calcification, Physiologic - physiology</subject><subject>Calcium</subject><subject>Case Studies</subject><subject>Child</subject><subject>Child development</subject><subject>Children & youth</subject><subject>Cross-Sectional Studies</subject><subject>dual energyx ray absorptiometry</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hydroxyapatite</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mineralization</subject><subject>Original</subject><subject>Osteoarticular system. Muscles</subject><subject>Osteoporosis</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Puberty</subject><subject>Puberty - physiology</subject><subject>R&D</subject><subject>Reference Values</subject><subject>Research & development</subject><subject>Retention</subject><subject>Sex Characteristics</subject><subject>Studies</subject><subject>Teenagers</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkUuLFDEUhYMoTtu6ci8FihupNo-qSrIRnGYcxUFd-MJNyOOWlbYqGZNqsf-9GbuZGV2IXEgW98u95-QgdJ_gFSGse6qdXQmyKoVvoAVpOlFT3DQ30QJjzGophDhCd3LeYEyoEOw2OiKYcUZou0Ann4Y4QmWi25UjQDX5AEmPlbY2wexjqHyoBtDjPOwqO_jRJQiVDq7SrrzMFsKc76JbvR4z3DvcS_Thxcn79cv67O3pq_Xzs9p0GM81a7Xk0DVOWimJpg1lIA2DhkoogMDEMUN4IxxtG2l4D8biru0tCMMdELZEz_Zzz7dmAnexu2hV58lPOu1U1F792Ql-UF_jD0U44WVlGfD4MCDF71vIs5p8sTCOOkDcZtVJKTj9D5BwxmnHaAEf_gVu4jaF8guF4Vx2LZa8UE_2lE0x5wT9pWaC1UWKqqSoBFGlcKEfXLd5jd3HVoBHB0Bnq8c-6WB9vuKE_K1uieo95vMMPy_bOn1TXdHfqjcf12r97vjz6Zdjql5fmTbT5p8CfwFkv7_e</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Mølgaard, Christian</creator><creator>Thomsen, Birthe Lykke</creator><creator>Michaelsen, Kim Fleischer</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QP</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19990701</creationdate><title>Whole body bone mineral accretion in healthy children and adolescents</title><author>Mølgaard, Christian ; Thomsen, Birthe Lykke ; Michaelsen, Kim Fleischer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b600t-35a97e64d9c991a2423e9b3e429e600801d3b1748d2549b7febc065fce8b7de13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Absorptiometry, Photon</topic><topic>Accretion</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Age</topic><topic>Age Factors</topic><topic>Anthropometry</topic><topic>Biological and medical sciences</topic><topic>Bone density</topic><topic>Bone Development - physiology</topic><topic>bone growth</topic><topic>bone mineral content</topic><topic>Bones</topic><topic>Calcification, Physiologic - physiology</topic><topic>Calcium</topic><topic>Case Studies</topic><topic>Child</topic><topic>Child development</topic><topic>Children & youth</topic><topic>Cross-Sectional Studies</topic><topic>dual energyx ray absorptiometry</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hydroxyapatite</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mineralization</topic><topic>Original</topic><topic>Osteoarticular system. 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Whole body bone mineral content (BMC) and bone area (BA) were determined by dual energy x ray absorptiometry (Hologic 1000/W) with a one year interval in healthy girls (n = 192) and boys (n = 140) aged 6–19 years. Annual accretion in BMC (ΔBMC (g/year)) and BA (ΔBA (cm2/year)) according to sex and pubertal stages were calculated. ΔBA and ΔBMC were highly significantly associated with pubertal stages in girls and boys. Centile curves for ΔBA and ΔBMC according to sex and age were constructed using the LMS method. Peak ΔBA and ΔBMC values were reached earlier in girls (12.3 and 12.5 years, respectively) than in boys (13.4 and 14.2 years, respectively). The ΔBA peak was dissociated in time from the ΔBMC peak, indicating that increase in bone size occurs before increase in bone mineral content. Assuming that 32.2% of BMC consist of calcium, the median (90th centile) annual bone calcium accretion in pubertal stage III was 220 mg/day (302) and 317 mg/day (386) for girls and boys, respectively. To obtain an average bone calcium accretion, a high calcium absorption is needed during puberty. This may have implications for dietary calcium requirements at this time.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>10373125</pmid><doi>10.1136/adc.81.1.10</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of disease in childhood, 1999-07, Vol.81 (1), p.10-15 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Absorptiometry, Photon Accretion Adolescent Adolescents Age Age Factors Anthropometry Biological and medical sciences Bone density Bone Development - physiology bone growth bone mineral content Bones Calcification, Physiologic - physiology Calcium Case Studies Child Child development Children & youth Cross-Sectional Studies dual energyx ray absorptiometry Female Follow-Up Studies Humans Hydroxyapatite Investigative techniques, diagnostic techniques (general aspects) Longitudinal Studies Male Medical sciences Mineralization Original Osteoarticular system. Muscles Osteoporosis Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Puberty Puberty - physiology R&D Reference Values Research & development Retention Sex Characteristics Studies Teenagers |
| title | Whole body bone mineral accretion in healthy children and adolescents |
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