Effect of growth hormone on height, weight, and body composition in Prader-Willi syndrome
AIMS To evaluate the effect of the administration of growth hormone on stature, body weight, and body composition in children aged between 4 and 10 years with Prader-Willi syndrome. METHODS Height, weight, and skinfold thickness were recorded in 25 children using standard anthropometric techniques a...
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| Veröffentlicht in: | Archives of disease in childhood 1998-05, Vol.78 (5), p.474-476 |
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| creator | Davies, P S W Evans, S Broomhead, S Clough, H Day, J M E Laidlaw, A Barnes, N D |
| description | AIMS To evaluate the effect of the administration of growth hormone on stature, body weight, and body composition in children aged between 4 and 10 years with Prader-Willi syndrome. METHODS Height, weight, and skinfold thickness were recorded in 25 children using standard anthropometric techniques at recruitment, and six months later, shortly before the start of daily subcutaneous injections of growth hormone. Body composition was assessed via a measurement of total body water using stable isotopes. Measurements were repeated at the end of the six months of growth hormone administration. Measurements of height, weight, and skinfold thickness were expressed as standard deviation scores (SDSs). RESULTS There was a significant reduction in the percentage of body fat after growth hormone treatment; height velocity doubled during treatment; body weight did not change significantly when expressed as an SDS. Skinfold thickness at both the triceps and subscapular site decreased in absolute terms and when expressed as an SDS. CONCLUSIONS These results indicate sufficient potential benefit to justify a more prolonged trial of growth hormone treatment and an exploration of different dosage regimens in children with Prader-Willi syndrome. |
| doi_str_mv | 10.1136/adc.78.5.474 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1717576</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4009093941</sourcerecordid><originalsourceid>FETCH-LOGICAL-b506t-4cd7bbc4dc00050b8678060a3b7c0ab5ac45aee868275706af7a32a8827d58103</originalsourceid><addsrcrecordid>eNp9kUuLFDEUhYMoYzu6cysEFN1MtUnlWRtBmnFUxsdi1HEVklSqK21V0ibVjv3vjXTRqAvv5nI5H4dzOQA8xGiJMeHPdWuXQi7Zkgp6Cyww5bKqEaW3wQIhRKpGSnkX3Mt5gxCupSQn4KThrEGNXICv513n7ARjB9cp3kw97GMaY3AwBtg7v-6nM3gzbx1aaGK7hzaO25j95AvkA_yYdOtS9cUPg4d5H9oUR3cf3On0kN2DeZ-CT6_Or1avq8sPF29WLy8rwxCfKmpbYYylrS1hGTKSC4k40sQIi7Rh2lKmnZNc1oIJxHUnNKm1LGfLJEbkFLw4-G53ZnStdWFKelDb5Eed9ipqr_5Wgu_VOv5QWODiyIvB09kgxe87lyc1-mzdMOjg4i4r0ZShpCng43_ATdylUJ4rXiW1rKmkhTo7UDbFnJPrjlEwUr8LU6UwJaRiqhRW8Ed_xj_Cc0NFfzLrOls9dEkH6_MRq2tCJGIFqw6Yz5P7eZR1-qa4IIKp959XiuGLt9fvroW6KvyzA2_Gzf8D_gLvrrn7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1778082484</pqid></control><display><type>article</type><title>Effect of growth hormone on height, weight, and body composition in Prader-Willi syndrome</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Davies, P S W ; Evans, S ; Broomhead, S ; Clough, H ; Day, J M E ; Laidlaw, A ; Barnes, N D</creator><creatorcontrib>Davies, P S W ; Evans, S ; Broomhead, S ; Clough, H ; Day, J M E ; Laidlaw, A ; Barnes, N D</creatorcontrib><description>AIMS To evaluate the effect of the administration of growth hormone on stature, body weight, and body composition in children aged between 4 and 10 years with Prader-Willi syndrome. METHODS Height, weight, and skinfold thickness were recorded in 25 children using standard anthropometric techniques at recruitment, and six months later, shortly before the start of daily subcutaneous injections of growth hormone. Body composition was assessed via a measurement of total body water using stable isotopes. Measurements were repeated at the end of the six months of growth hormone administration. Measurements of height, weight, and skinfold thickness were expressed as standard deviation scores (SDSs). RESULTS There was a significant reduction in the percentage of body fat after growth hormone treatment; height velocity doubled during treatment; body weight did not change significantly when expressed as an SDS. Skinfold thickness at both the triceps and subscapular site decreased in absolute terms and when expressed as an SDS. CONCLUSIONS These results indicate sufficient potential benefit to justify a more prolonged trial of growth hormone treatment and an exploration of different dosage regimens in children with Prader-Willi syndrome.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.78.5.474</identifier><identifier>PMID: 9659098</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Age ; Biological and medical sciences ; Body composition ; Body Composition - drug effects ; Body fat ; Body Height - drug effects ; Body weight ; Body Weight - drug effects ; Child ; Child, Preschool ; Children & youth ; Drinking water ; Drug Administration Schedule ; Endocrinopathies ; Expected values ; Female ; Follow-Up Studies ; General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes ; Growth - drug effects ; growth hormone ; Growth hormones ; Human Growth Hormone - therapeutic use ; Humans ; Male ; Medical sciences ; Multiple Regression Analysis ; Obesity ; Original ; Pituitary gland ; Prader-Willi syndrome ; Prader-Willi Syndrome - drug therapy ; Prader-Willi Syndrome - physiopathology ; Recruitment ; Skinfold Thickness ; Stable isotopes ; Urine</subject><ispartof>Archives of disease in childhood, 1998-05, Vol.78 (5), p.474-476</ispartof><rights>Royal College of Paediatrics and Child Health</rights><rights>1998 INIST-CNRS</rights><rights>Copyright: 1998 Royal College of Paediatrics and Child Health</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b506t-4cd7bbc4dc00050b8678060a3b7c0ab5ac45aee868275706af7a32a8827d58103</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1717576/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1717576/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2233805$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9659098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davies, P S W</creatorcontrib><creatorcontrib>Evans, S</creatorcontrib><creatorcontrib>Broomhead, S</creatorcontrib><creatorcontrib>Clough, H</creatorcontrib><creatorcontrib>Day, J M E</creatorcontrib><creatorcontrib>Laidlaw, A</creatorcontrib><creatorcontrib>Barnes, N D</creatorcontrib><title>Effect of growth hormone on height, weight, and body composition in Prader-Willi syndrome</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>AIMS To evaluate the effect of the administration of growth hormone on stature, body weight, and body composition in children aged between 4 and 10 years with Prader-Willi syndrome. METHODS Height, weight, and skinfold thickness were recorded in 25 children using standard anthropometric techniques at recruitment, and six months later, shortly before the start of daily subcutaneous injections of growth hormone. Body composition was assessed via a measurement of total body water using stable isotopes. Measurements were repeated at the end of the six months of growth hormone administration. Measurements of height, weight, and skinfold thickness were expressed as standard deviation scores (SDSs). RESULTS There was a significant reduction in the percentage of body fat after growth hormone treatment; height velocity doubled during treatment; body weight did not change significantly when expressed as an SDS. Skinfold thickness at both the triceps and subscapular site decreased in absolute terms and when expressed as an SDS. CONCLUSIONS These results indicate sufficient potential benefit to justify a more prolonged trial of growth hormone treatment and an exploration of different dosage regimens in children with Prader-Willi syndrome.</description><subject>Age</subject><subject>Biological and medical sciences</subject><subject>Body composition</subject><subject>Body Composition - drug effects</subject><subject>Body fat</subject><subject>Body Height - drug effects</subject><subject>Body weight</subject><subject>Body Weight - drug effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Drinking water</subject><subject>Drug Administration Schedule</subject><subject>Endocrinopathies</subject><subject>Expected values</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes</subject><subject>Growth - drug effects</subject><subject>growth hormone</subject><subject>Growth hormones</subject><subject>Human Growth Hormone - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multiple Regression Analysis</subject><subject>Obesity</subject><subject>Original</subject><subject>Pituitary gland</subject><subject>Prader-Willi syndrome</subject><subject>Prader-Willi Syndrome - drug therapy</subject><subject>Prader-Willi Syndrome - physiopathology</subject><subject>Recruitment</subject><subject>Skinfold Thickness</subject><subject>Stable isotopes</subject><subject>Urine</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUuLFDEUhYMoYzu6cysEFN1MtUnlWRtBmnFUxsdi1HEVklSqK21V0ibVjv3vjXTRqAvv5nI5H4dzOQA8xGiJMeHPdWuXQi7Zkgp6Cyww5bKqEaW3wQIhRKpGSnkX3Mt5gxCupSQn4KThrEGNXICv513n7ARjB9cp3kw97GMaY3AwBtg7v-6nM3gzbx1aaGK7hzaO25j95AvkA_yYdOtS9cUPg4d5H9oUR3cf3On0kN2DeZ-CT6_Or1avq8sPF29WLy8rwxCfKmpbYYylrS1hGTKSC4k40sQIi7Rh2lKmnZNc1oIJxHUnNKm1LGfLJEbkFLw4-G53ZnStdWFKelDb5Eed9ipqr_5Wgu_VOv5QWODiyIvB09kgxe87lyc1-mzdMOjg4i4r0ZShpCng43_ATdylUJ4rXiW1rKmkhTo7UDbFnJPrjlEwUr8LU6UwJaRiqhRW8Ed_xj_Cc0NFfzLrOls9dEkH6_MRq2tCJGIFqw6Yz5P7eZR1-qa4IIKp959XiuGLt9fvroW6KvyzA2_Gzf8D_gLvrrn7</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Davies, P S W</creator><creator>Evans, S</creator><creator>Broomhead, S</creator><creator>Clough, H</creator><creator>Day, J M E</creator><creator>Laidlaw, A</creator><creator>Barnes, N D</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19980501</creationdate><title>Effect of growth hormone on height, weight, and body composition in Prader-Willi syndrome</title><author>Davies, P S W ; Evans, S ; Broomhead, S ; Clough, H ; Day, J M E ; Laidlaw, A ; Barnes, N D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b506t-4cd7bbc4dc00050b8678060a3b7c0ab5ac45aee868275706af7a32a8827d58103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Age</topic><topic>Biological and medical sciences</topic><topic>Body composition</topic><topic>Body Composition - drug effects</topic><topic>Body fat</topic><topic>Body Height - drug effects</topic><topic>Body weight</topic><topic>Body Weight - drug effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Drinking water</topic><topic>Drug Administration Schedule</topic><topic>Endocrinopathies</topic><topic>Expected values</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes</topic><topic>Growth - drug effects</topic><topic>growth hormone</topic><topic>Growth hormones</topic><topic>Human Growth Hormone - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multiple Regression Analysis</topic><topic>Obesity</topic><topic>Original</topic><topic>Pituitary gland</topic><topic>Prader-Willi syndrome</topic><topic>Prader-Willi Syndrome - drug therapy</topic><topic>Prader-Willi Syndrome - physiopathology</topic><topic>Recruitment</topic><topic>Skinfold Thickness</topic><topic>Stable isotopes</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davies, P S W</creatorcontrib><creatorcontrib>Evans, S</creatorcontrib><creatorcontrib>Broomhead, S</creatorcontrib><creatorcontrib>Clough, H</creatorcontrib><creatorcontrib>Day, J M E</creatorcontrib><creatorcontrib>Laidlaw, A</creatorcontrib><creatorcontrib>Barnes, N D</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davies, P S W</au><au>Evans, S</au><au>Broomhead, S</au><au>Clough, H</au><au>Day, J M E</au><au>Laidlaw, A</au><au>Barnes, N D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of growth hormone on height, weight, and body composition in Prader-Willi syndrome</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>78</volume><issue>5</issue><spage>474</spage><epage>476</epage><pages>474-476</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>AIMS To evaluate the effect of the administration of growth hormone on stature, body weight, and body composition in children aged between 4 and 10 years with Prader-Willi syndrome. METHODS Height, weight, and skinfold thickness were recorded in 25 children using standard anthropometric techniques at recruitment, and six months later, shortly before the start of daily subcutaneous injections of growth hormone. Body composition was assessed via a measurement of total body water using stable isotopes. Measurements were repeated at the end of the six months of growth hormone administration. Measurements of height, weight, and skinfold thickness were expressed as standard deviation scores (SDSs). RESULTS There was a significant reduction in the percentage of body fat after growth hormone treatment; height velocity doubled during treatment; body weight did not change significantly when expressed as an SDS. Skinfold thickness at both the triceps and subscapular site decreased in absolute terms and when expressed as an SDS. CONCLUSIONS These results indicate sufficient potential benefit to justify a more prolonged trial of growth hormone treatment and an exploration of different dosage regimens in children with Prader-Willi syndrome.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>9659098</pmid><doi>10.1136/adc.78.5.474</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of disease in childhood, 1998-05, Vol.78 (5), p.474-476 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Age Biological and medical sciences Body composition Body Composition - drug effects Body fat Body Height - drug effects Body weight Body Weight - drug effects Child Child, Preschool Children & youth Drinking water Drug Administration Schedule Endocrinopathies Expected values Female Follow-Up Studies General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes Growth - drug effects growth hormone Growth hormones Human Growth Hormone - therapeutic use Humans Male Medical sciences Multiple Regression Analysis Obesity Original Pituitary gland Prader-Willi syndrome Prader-Willi Syndrome - drug therapy Prader-Willi Syndrome - physiopathology Recruitment Skinfold Thickness Stable isotopes Urine |
| title | Effect of growth hormone on height, weight, and body composition in Prader-Willi syndrome |
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